Maternal Obesity, Overweight and Gestational Diabetes Affect the Offspring Neurodevelopment at 6 and 18 Months of Age--A Follow Up from the PREOBE Cohort
Brain development in fetal life and early infancy is critical to determine lifelong performance in various neuropsychological domains. Metabolic pathologies such as overweight, obesity, and gestational diabetes in pregnant women are prevalent and increasing risk factors that may adversely affect lon...
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| Veröffentlicht in: | PloS one 2015-07, Vol.10 (7), p.e0133010-e0133010 |
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| creator | Torres-Espinola, Francisco J Berglund, Staffan K García-Valdés, Luz Ma Segura, Ma Teresa Jerez, Antonio Campos, Daniel Moreno-Torres, Rosario Rueda, Ricardo Catena, Andrés Pérez-García, Miguel Campoy, Cristina |
| description | Brain development in fetal life and early infancy is critical to determine lifelong performance in various neuropsychological domains. Metabolic pathologies such as overweight, obesity, and gestational diabetes in pregnant women are prevalent and increasing risk factors that may adversely affect long-term brain development in their offspring.
The objective of this research was to investigate the influence of maternal metabolic pathologies on the neurodevelopment of the offspring at 6 and 18 months of life.
This was a prospective case-control study of 331 mother- and child pairs from Granada, Spain. The mothers were included during pregnancy into four groups according to their pre-gestational body mass index and their gestational diabetes status; overweight (n:56), obese (n:64), gestational diabetic (n:79), and healthy normal weight controls (n:132). At 6 months and 18 months we assessed the children with the Bayley III scales of neurodevelopment.
At 6 months (n=215), we found significant group differences in cognition composite language, and expressive language. Post hoc test revealed unexpectedly higher scores in the obese group compared to the normal weight group and a similar trend in overweight and diabetic group. The effects on language remained significant after adjusting for confounders with an adjusted odds ratio for a value above median in composite language score of 3.3 (95% CI: 1.1, 10.0; p=0.035) for children of obese mothers. At 18 month (n=197), the offspring born to obese mothers had lost five points in language composite scores and the previous differences in language and cognition was replaced by a suggestive trend of lower gross motor scores in the overweight, obese, and diabetic groups.
Infants of obese mothers had a temporary accelerated development of cognition and language, followed by a rapid deceleration until 18 months of age, particularly of language scores. This novel observation prompts further confirmative studies to explore possible placental and neurodevelopmental mechanisms involved. |
| doi_str_mv | 10.1371/journal.pone.0133010 |
| format | Article |
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The objective of this research was to investigate the influence of maternal metabolic pathologies on the neurodevelopment of the offspring at 6 and 18 months of life.
This was a prospective case-control study of 331 mother- and child pairs from Granada, Spain. The mothers were included during pregnancy into four groups according to their pre-gestational body mass index and their gestational diabetes status; overweight (n:56), obese (n:64), gestational diabetic (n:79), and healthy normal weight controls (n:132). At 6 months and 18 months we assessed the children with the Bayley III scales of neurodevelopment.
At 6 months (n=215), we found significant group differences in cognition composite language, and expressive language. Post hoc test revealed unexpectedly higher scores in the obese group compared to the normal weight group and a similar trend in overweight and diabetic group. The effects on language remained significant after adjusting for confounders with an adjusted odds ratio for a value above median in composite language score of 3.3 (95% CI: 1.1, 10.0; p=0.035) for children of obese mothers. At 18 month (n=197), the offspring born to obese mothers had lost five points in language composite scores and the previous differences in language and cognition was replaced by a suggestive trend of lower gross motor scores in the overweight, obese, and diabetic groups.
Infants of obese mothers had a temporary accelerated development of cognition and language, followed by a rapid deceleration until 18 months of age, particularly of language scores. This novel observation prompts further confirmative studies to explore possible placental and neurodevelopmental mechanisms involved.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0133010</identifier><identifier>PMID: 26208217</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Body mass ; Body mass index ; Body size ; Body weight ; Brain ; Brain research ; Case-Control Studies ; Child & adolescent psychiatry ; Children ; Children & youth ; Cognition ; Collaboration ; Deceleration ; Diabetes ; Diabetes mellitus ; Diabetes, Gestational ; Epidemiology ; Female ; Fetuses ; Follow-Up Studies ; Gestational diabetes ; Humans ; Infant ; Infants ; Language ; Male ; Maternal & child health ; Maternal Exposure - adverse effects ; Mothers ; Neurodevelopment ; Obesity ; Offspring ; Overweight ; Placenta ; Pregnancy ; Prenatal Exposure Delayed Effects ; Progeny ; Prospective Studies ; Risk analysis ; Risk factors ; Studies ; Womens health</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0133010-e0133010</ispartof><rights>2015 Torres-Espinola et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Torres-Espinola et al 2015 Torres-Espinola et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-ea8d22e3e9bd2e88a65c937b60601f7ec2e09ceaf8e33478ef2fb3913a44a86b3</citedby><cites>FETCH-LOGICAL-c564t-ea8d22e3e9bd2e88a65c937b60601f7ec2e09ceaf8e33478ef2fb3913a44a86b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514597/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514597/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,551,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26208217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-107295$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Baud, Olivier</contributor><creatorcontrib>Torres-Espinola, Francisco J</creatorcontrib><creatorcontrib>Berglund, Staffan K</creatorcontrib><creatorcontrib>García-Valdés, Luz Ma</creatorcontrib><creatorcontrib>Segura, Ma Teresa</creatorcontrib><creatorcontrib>Jerez, Antonio</creatorcontrib><creatorcontrib>Campos, Daniel</creatorcontrib><creatorcontrib>Moreno-Torres, Rosario</creatorcontrib><creatorcontrib>Rueda, Ricardo</creatorcontrib><creatorcontrib>Catena, Andrés</creatorcontrib><creatorcontrib>Pérez-García, Miguel</creatorcontrib><creatorcontrib>Campoy, Cristina</creatorcontrib><creatorcontrib>PREOBE team</creatorcontrib><title>Maternal Obesity, Overweight and Gestational Diabetes Affect the Offspring Neurodevelopment at 6 and 18 Months of Age--A Follow Up from the PREOBE Cohort</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Brain development in fetal life and early infancy is critical to determine lifelong performance in various neuropsychological domains. Metabolic pathologies such as overweight, obesity, and gestational diabetes in pregnant women are prevalent and increasing risk factors that may adversely affect long-term brain development in their offspring.
The objective of this research was to investigate the influence of maternal metabolic pathologies on the neurodevelopment of the offspring at 6 and 18 months of life.
This was a prospective case-control study of 331 mother- and child pairs from Granada, Spain. The mothers were included during pregnancy into four groups according to their pre-gestational body mass index and their gestational diabetes status; overweight (n:56), obese (n:64), gestational diabetic (n:79), and healthy normal weight controls (n:132). At 6 months and 18 months we assessed the children with the Bayley III scales of neurodevelopment.
At 6 months (n=215), we found significant group differences in cognition composite language, and expressive language. Post hoc test revealed unexpectedly higher scores in the obese group compared to the normal weight group and a similar trend in overweight and diabetic group. The effects on language remained significant after adjusting for confounders with an adjusted odds ratio for a value above median in composite language score of 3.3 (95% CI: 1.1, 10.0; p=0.035) for children of obese mothers. At 18 month (n=197), the offspring born to obese mothers had lost five points in language composite scores and the previous differences in language and cognition was replaced by a suggestive trend of lower gross motor scores in the overweight, obese, and diabetic groups.
Infants of obese mothers had a temporary accelerated development of cognition and language, followed by a rapid deceleration until 18 months of age, particularly of language scores. 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Affect the Offspring Neurodevelopment at 6 and 18 Months of Age--A Follow Up from the PREOBE Cohort</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-24</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0133010</spage><epage>e0133010</epage><pages>e0133010-e0133010</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Brain development in fetal life and early infancy is critical to determine lifelong performance in various neuropsychological domains. Metabolic pathologies such as overweight, obesity, and gestational diabetes in pregnant women are prevalent and increasing risk factors that may adversely affect long-term brain development in their offspring.
The objective of this research was to investigate the influence of maternal metabolic pathologies on the neurodevelopment of the offspring at 6 and 18 months of life.
This was a prospective case-control study of 331 mother- and child pairs from Granada, Spain. The mothers were included during pregnancy into four groups according to their pre-gestational body mass index and their gestational diabetes status; overweight (n:56), obese (n:64), gestational diabetic (n:79), and healthy normal weight controls (n:132). At 6 months and 18 months we assessed the children with the Bayley III scales of neurodevelopment.
At 6 months (n=215), we found significant group differences in cognition composite language, and expressive language. Post hoc test revealed unexpectedly higher scores in the obese group compared to the normal weight group and a similar trend in overweight and diabetic group. The effects on language remained significant after adjusting for confounders with an adjusted odds ratio for a value above median in composite language score of 3.3 (95% CI: 1.1, 10.0; p=0.035) for children of obese mothers. At 18 month (n=197), the offspring born to obese mothers had lost five points in language composite scores and the previous differences in language and cognition was replaced by a suggestive trend of lower gross motor scores in the overweight, obese, and diabetic groups.
Infants of obese mothers had a temporary accelerated development of cognition and language, followed by a rapid deceleration until 18 months of age, particularly of language scores. This novel observation prompts further confirmative studies to explore possible placental and neurodevelopmental mechanisms involved.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26208217</pmid><doi>10.1371/journal.pone.0133010</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-07, Vol.10 (7), p.e0133010-e0133010 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1698612316 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; SWEPUB Freely available online; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Body mass Body mass index Body size Body weight Brain Brain research Case-Control Studies Child & adolescent psychiatry Children Children & youth Cognition Collaboration Deceleration Diabetes Diabetes mellitus Diabetes, Gestational Epidemiology Female Fetuses Follow-Up Studies Gestational diabetes Humans Infant Infants Language Male Maternal & child health Maternal Exposure - adverse effects Mothers Neurodevelopment Obesity Offspring Overweight Placenta Pregnancy Prenatal Exposure Delayed Effects Progeny Prospective Studies Risk analysis Risk factors Studies Womens health |
| title | Maternal Obesity, Overweight and Gestational Diabetes Affect the Offspring Neurodevelopment at 6 and 18 Months of Age--A Follow Up from the PREOBE Cohort |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T20%3A54%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Maternal%20Obesity,%20Overweight%20and%20Gestational%20Diabetes%20Affect%20the%20Offspring%20Neurodevelopment%20at%206%20and%2018%20Months%20of%20Age--A%20Follow%20Up%20from%20the%20PREOBE%20Cohort&rft.jtitle=PloS%20one&rft.au=Torres-Espinola,%20Francisco%20J&rft.aucorp=PREOBE%20team&rft.date=2015-07-24&rft.volume=10&rft.issue=7&rft.spage=e0133010&rft.epage=e0133010&rft.pages=e0133010-e0133010&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0133010&rft_dat=%3Cproquest_plos_%3E1699493202%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1698612316&rft_id=info:pmid/26208217&rft_doaj_id=oai_doaj_org_article_1349eb646d4743c6843e9482fbfd14cc&rfr_iscdi=true |