Partial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration

Liver regeneration after partial hepatectomy (PHx) is a complex and well-orchestrated biological process in which synchronized cell proliferation is induced in response to the loss of liver mass. To define long noncoding RNAs (lncRNAs) that participate in the regulation of liver regeneration, we per...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132798-e0132798
Hauptverfasser:	Huang, Lulu, Damle, Sagar S, Booten, Sheri, Singh, Priyam, Sabripour, Mahyar, Hsu, Jeff, Jo, Minji, Katz, Melanie, Watt, Andy, Hart, Christopher E, Freier, Susan M, Monia, Brett P, Guo, Shuling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antisense oligonucleotides Bioinformatics Biological activity Cell adhesion & migration Cell cycle Cell growth Cell proliferation Cell Proliferation - genetics Cells, Cultured Deoxyribonucleic acid Depletion DNA DNA microarrays DNA-directed DNA polymerase Feedback loops Gene expression Gene Expression Profiling Genomes Genomics Hepatectomy Hepatocytes - physiology Liver Liver Regeneration - genetics Male Mice Mice, Inbred C57BL Microarray Analysis Negative feedback Oligonucleotides Pharmaceuticals Post-transcription Proteins R&D Regeneration Research & development Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - physiology Stem cells Transcription factors Up-Regulation - genetics
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