Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes

High rates of error-prone replication result in the rapid accumulation of genetic diversity of RNA viruses. Recent studies suggest that mutation rates are selected for optimal viral fitness and that modest variations in replicase fidelity may be associated with viral attenuation. Arthropod-borne vir...

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Veröffentlicht in:	PLoS pathogens 2015-06, Vol.11 (6), p.e1005009
Hauptverfasser:	Van Slyke, Greta A, Arnold, Jamie J, Lugo, Alex J, Griesemer, Sara B, Moustafa, Ibrahim M, Kramer, Laura D, Cameron, Craig E, Ciota, Alexander T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cell culture Culicidae - virology Genetic Variation - genetics Host-Pathogen Interactions - genetics Mosquitoes Mutation Mutation - genetics RNA-Dependent RNA Polymerase - genetics Studies Virus Replication - genetics West Nile virus West Nile virus - genetics
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