Associations between NBS1 Polymorphisms and Colorectal Cancer in Chinese Population

As the central protein of the double strand breaks (DSB)-induced DNA repair pathway, NBS1 participates in detecting the DSBs and plays an essential role in maintaining genomic stability. Single nucleotide polymorphisms (SNPs) in NBS1 gene were commonly tested that associated with the susceptibility...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132332-e0132332
Hauptverfasser:	Li, Jing-Tao, Zhong, Bao-Yuan, Xu, Hui-Hui, Qiao, Sheng-Yan, Wang, Gui, Huang, Jing, Fan, Hui-Zhen, Zhao, Hong-Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Adult Age Aged Aged, 80 and over Asian Continental Ancestry Group - genetics Ataxia Base Sequence Binding sites Biology Breast cancer Cancer Cell Cycle Proteins - genetics Chromosomes Clinical medicine Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Committees Confidence intervals Deoxyribonucleic acid DNA DNA damage DNA methylation DNA repair Double-strand break repair Gastroenterology Gene Expression Regulation, Neoplastic Gene polymorphism Genes Genes, Reporter Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Genomes Genotypes Health aspects Health risks Hospitals Humans Kinases Luciferases - metabolism Lung cancer Lymphoma Medical ethics Medical research Medicine Middle Aged Molecular Sequence Data NBS1 gene Nuclear Proteins - genetics Plasmids Polymorphism Polymorphism, Single Nucleotide - genetics Population Radiation therapy Risk Risk Factors RNA, Messenger - genetics RNA, Messenger - metabolism Single nucleotide polymorphisms Single-nucleotide polymorphism Statistical analysis Transcription Transcription, Genetic Young Adult
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