Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration
The analysis of the MR phase provides additional information on the tissue microstructure. In multiple sclerosis (MS) lesions phase alterations may reflect different stages of inflammatory activity. Here we investigated lesion morphology in MS patients with short and long disease duration on T2* wei...
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| creator | Bozin, Ivan Ge, Yulin Kuchling, Joseph Dusek, Petr Chawla, Sanjeev Harms, Lutz Ruprecht, Klemens Niendorf, Thoralf Paul, Friedemann Kister, Ilya Sinnecker, Tim Wuerfel, Jens |
| description | The analysis of the MR phase provides additional information on the tissue microstructure. In multiple sclerosis (MS) lesions phase alterations may reflect different stages of inflammatory activity. Here we investigated lesion morphology in MS patients with short and long disease duration on T2* weighted, phase, magnitude and susceptibility weighted imaging (SWI) at 7 Tesla (T).
17 MS or clinically isolated syndrome patients with short (60 months) disease duration underwent 7 T MRI. Lesions were subsequently analyzed side-by-side with regard to morphology and visibility on T2* weighted, SWI, magnitude and SWI-filtered phase images.
126 of 192 T2* weighted lesions (65.6%) were characterized by a phase alteration pattern, and hence could be differentiated on phase images. In detail, a significantly reduced proportion of lesions showing phase alterations was detectable in patients with longer disease duration (mean±SD 51 ± 37%, range 0-100%) compared to patients with short disease duration (mean ± SD 90 ± 19.5%, range 50-100%, p = 0.003).
This cross-sectional study identified different patterns of phase changes in lesions of MS patients with short and long standing disease. Longitudinal studies are warranted to prove that MR phase imaging is useful in determining the activity and the developmental stage of individual MS plaques. |
| doi_str_mv | 10.1371/journal.pone.0128386 |
| format | Article |
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17 MS or clinically isolated syndrome patients with short (<60 months) and 11 with long (>60 months) disease duration underwent 7 T MRI. Lesions were subsequently analyzed side-by-side with regard to morphology and visibility on T2* weighted, SWI, magnitude and SWI-filtered phase images.
126 of 192 T2* weighted lesions (65.6%) were characterized by a phase alteration pattern, and hence could be differentiated on phase images. In detail, a significantly reduced proportion of lesions showing phase alterations was detectable in patients with longer disease duration (mean±SD 51 ± 37%, range 0-100%) compared to patients with short disease duration (mean ± SD 90 ± 19.5%, range 50-100%, p = 0.003).
This cross-sectional study identified different patterns of phase changes in lesions of MS patients with short and long standing disease. Longitudinal studies are warranted to prove that MR phase imaging is useful in determining the activity and the developmental stage of individual MS plaques.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0128386</identifier><identifier>PMID: 26186349</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Brain - pathology ; Brain research ; Correlation analysis ; Cross-Sectional Studies ; Diagnostic imaging ; Disease Progression ; Female ; Humans ; Inflammation ; Iron ; Lesions ; Longitudinal studies ; Magnetic permeability ; Magnetic resonance ; Magnetic resonance imaging ; Magnetic Resonance Imaging - instrumentation ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Middle Aged ; Morphology ; Multiple sclerosis ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - pathology ; Neurology ; NMR ; Nuclear magnetic resonance ; Patients ; Phase transitions ; Plaques ; Radiology ; Time Factors</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0128386-e0128386</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Bozin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Bozin et al 2015 Bozin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-99e850667d70d1c198fc458a6926f1c57cce3858aad1ddf8c1b720ffb71a19d43</citedby><cites>FETCH-LOGICAL-c692t-99e850667d70d1c198fc458a6926f1c57cce3858aad1ddf8c1b720ffb71a19d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506094/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506094/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26186349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wang, Yi</contributor><creatorcontrib>Bozin, Ivan</creatorcontrib><creatorcontrib>Ge, Yulin</creatorcontrib><creatorcontrib>Kuchling, Joseph</creatorcontrib><creatorcontrib>Dusek, Petr</creatorcontrib><creatorcontrib>Chawla, Sanjeev</creatorcontrib><creatorcontrib>Harms, Lutz</creatorcontrib><creatorcontrib>Ruprecht, Klemens</creatorcontrib><creatorcontrib>Niendorf, Thoralf</creatorcontrib><creatorcontrib>Paul, Friedemann</creatorcontrib><creatorcontrib>Kister, Ilya</creatorcontrib><creatorcontrib>Sinnecker, Tim</creatorcontrib><creatorcontrib>Wuerfel, Jens</creatorcontrib><title>Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The analysis of the MR phase provides additional information on the tissue microstructure. In multiple sclerosis (MS) lesions phase alterations may reflect different stages of inflammatory activity. Here we investigated lesion morphology in MS patients with short and long disease duration on T2* weighted, phase, magnitude and susceptibility weighted imaging (SWI) at 7 Tesla (T).
17 MS or clinically isolated syndrome patients with short (<60 months) and 11 with long (>60 months) disease duration underwent 7 T MRI. Lesions were subsequently analyzed side-by-side with regard to morphology and visibility on T2* weighted, SWI, magnitude and SWI-filtered phase images.
126 of 192 T2* weighted lesions (65.6%) were characterized by a phase alteration pattern, and hence could be differentiated on phase images. In detail, a significantly reduced proportion of lesions showing phase alterations was detectable in patients with longer disease duration (mean±SD 51 ± 37%, range 0-100%) compared to patients with short disease duration (mean ± SD 90 ± 19.5%, range 50-100%, p = 0.003).
This cross-sectional study identified different patterns of phase changes in lesions of MS patients with short and long standing disease. Longitudinal studies are warranted to prove that MR phase imaging is useful in determining the activity and the developmental stage of individual MS plaques.</description><subject>Adult</subject><subject>Brain - pathology</subject><subject>Brain research</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Diagnostic imaging</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Iron</subject><subject>Lesions</subject><subject>Longitudinal studies</subject><subject>Magnetic permeability</subject><subject>Magnetic resonance</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - instrumentation</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - 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pathology</topic><topic>Brain research</topic><topic>Correlation analysis</topic><topic>Cross-Sectional Studies</topic><topic>Diagnostic imaging</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Iron</topic><topic>Lesions</topic><topic>Longitudinal studies</topic><topic>Magnetic permeability</topic><topic>Magnetic resonance</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - instrumentation</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - pathology</topic><topic>Neurology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Phase transitions</topic><topic>Plaques</topic><topic>Radiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bozin, Ivan</creatorcontrib><creatorcontrib>Ge, Yulin</creatorcontrib><creatorcontrib>Kuchling, Joseph</creatorcontrib><creatorcontrib>Dusek, Petr</creatorcontrib><creatorcontrib>Chawla, Sanjeev</creatorcontrib><creatorcontrib>Harms, Lutz</creatorcontrib><creatorcontrib>Ruprecht, Klemens</creatorcontrib><creatorcontrib>Niendorf, Thoralf</creatorcontrib><creatorcontrib>Paul, Friedemann</creatorcontrib><creatorcontrib>Kister, Ilya</creatorcontrib><creatorcontrib>Sinnecker, Tim</creatorcontrib><creatorcontrib>Wuerfel, Jens</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bozin, Ivan</au><au>Ge, Yulin</au><au>Kuchling, Joseph</au><au>Dusek, Petr</au><au>Chawla, Sanjeev</au><au>Harms, Lutz</au><au>Ruprecht, Klemens</au><au>Niendorf, Thoralf</au><au>Paul, Friedemann</au><au>Kister, Ilya</au><au>Sinnecker, Tim</au><au>Wuerfel, Jens</au><au>Wang, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-17</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0128386</spage><epage>e0128386</epage><pages>e0128386-e0128386</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The analysis of the MR phase provides additional information on the tissue microstructure. In multiple sclerosis (MS) lesions phase alterations may reflect different stages of inflammatory activity. Here we investigated lesion morphology in MS patients with short and long disease duration on T2* weighted, phase, magnitude and susceptibility weighted imaging (SWI) at 7 Tesla (T).
17 MS or clinically isolated syndrome patients with short (<60 months) and 11 with long (>60 months) disease duration underwent 7 T MRI. Lesions were subsequently analyzed side-by-side with regard to morphology and visibility on T2* weighted, SWI, magnitude and SWI-filtered phase images.
126 of 192 T2* weighted lesions (65.6%) were characterized by a phase alteration pattern, and hence could be differentiated on phase images. In detail, a significantly reduced proportion of lesions showing phase alterations was detectable in patients with longer disease duration (mean±SD 51 ± 37%, range 0-100%) compared to patients with short disease duration (mean ± SD 90 ± 19.5%, range 50-100%, p = 0.003).
This cross-sectional study identified different patterns of phase changes in lesions of MS patients with short and long standing disease. Longitudinal studies are warranted to prove that MR phase imaging is useful in determining the activity and the developmental stage of individual MS plaques.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26186349</pmid><doi>10.1371/journal.pone.0128386</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Brain - pathology Brain research Correlation analysis Cross-Sectional Studies Diagnostic imaging Disease Progression Female Humans Inflammation Iron Lesions Longitudinal studies Magnetic permeability Magnetic resonance Magnetic resonance imaging Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Male Medicine Middle Aged Morphology Multiple sclerosis Multiple Sclerosis - diagnosis Multiple Sclerosis - pathology Neurology NMR Nuclear magnetic resonance Patients Phase transitions Plaques Radiology Time Factors |
| title | Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration |
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