Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery

Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity. In the present study we developed a computational approach that utilized data from...

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Veröffentlicht in:	PLoS neglected tropical diseases 2015-06, Vol.9 (6), p.e0003878-e0003878
Hauptverfasser:	Ekins, Sean, de Siqueira-Neto, Jair Lage, McCall, Laura-Isobel, Sarker, Malabika, Yadav, Maneesh, Ponder, Elizabeth L, Kallel, E Adam, Kellar, Danielle, Chen, Steven, Arkin, Michelle, Bunin, Barry A, McKerrow, James H, Talcott, Carolyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bayes Theorem Cell Line Chagas Disease - drug therapy Chagas Disease - parasitology Collaboration Computational Biology Disease Models, Animal Drug Discovery - methods Female Genome, Protozoan - genetics High-Throughput Screening Assays Humans Machine Learning Metabolic Networks and Pathways Mice Mice, Inbred BALB C Parasites Pharmaceutical industry Protozoa Tropical diseases Trypanocidal Agents - isolation & purification Trypanocidal Agents - pharmacology Trypanosoma cruzi - drug effects Trypanosoma cruzi - genetics
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