Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer disease (AD) and represent promising targets for intervention. However, the causality of these associations is unclear. We sought to assess the causal nature of these associations...

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Veröffentlicht in:	PLoS medicine 2015-06, Vol.12 (6), p.e1001841; discussion e1001841
Hauptverfasser:	Østergaard, Søren D, Mukherjee, Shubhabrata, Sharp, Stephen J, Proitsi, Petroula, Lotta, Luca A, Day, Felix, Perry, John R B, Boehme, Kevin L, Walter, Stefan, Kauwe, John S, Gibbons, Laura E, Larson, Eric B, Powell, John F, Langenberg, Claudia, Crane, Paul K, Wareham, Nicholas J, Scott, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Blood pressure Cholesterol Consortia Dementia Diabetes Female Genetic Predisposition to Disease Health risk assessment Humans Hypertension Low density lipoprotein Male Mendelian Randomization Analysis Polymorphism, Single Nucleotide Researchers Risk Factors Smoking Studies
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