Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose
D-galactose injection has been shown to induce many changes in mice that represent accelerated aging. This mouse model has been widely used for pharmacological studies of anti-aging agents. The underlying mechanism of D-galactose induced aging remains unclear, however, it appears to relate to glucos...
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| Veröffentlicht in: | PloS one 2015-07, Vol.10 (7), p.e0132088-e0132088 |
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| creator | Zhou, Yue-Yue Ji, Xiong-Fei Fu, Jian-Ping Zhu, Xiao-Juan Li, Rong-Hua Mu, Chang-Kao Wang, Chun-Lin Song, Wei-Wei |
| description | D-galactose injection has been shown to induce many changes in mice that represent accelerated aging. This mouse model has been widely used for pharmacological studies of anti-aging agents. The underlying mechanism of D-galactose induced aging remains unclear, however, it appears to relate to glucose and 1ipid metabolic disorders. Currently, there has yet to be a study that focuses on investigating gene expression changes in D-galactose aging mice. In this study, integrated analysis of gas chromatography/mass spectrometry-based metabonomics and gene expression profiles was used to investigate the changes in transcriptional and metabolic profiles in mimetic aging mice injected with D-galactose. Our findings demonstrated that 48 mRNAs were differentially expressed between control and D-galactose mice, and 51 potential biomarkers were identified at the metabolic level. The effects of D-galactose on aging could be attributed to glucose and 1ipid metabolic disorders, oxidative damage, accumulation of advanced glycation end products (AGEs), reduction in abnormal substance elimination, cell apoptosis, and insulin resistance. |
| doi_str_mv | 10.1371/journal.pone.0132088 |
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This mouse model has been widely used for pharmacological studies of anti-aging agents. The underlying mechanism of D-galactose induced aging remains unclear, however, it appears to relate to glucose and 1ipid metabolic disorders. Currently, there has yet to be a study that focuses on investigating gene expression changes in D-galactose aging mice. In this study, integrated analysis of gas chromatography/mass spectrometry-based metabonomics and gene expression profiles was used to investigate the changes in transcriptional and metabolic profiles in mimetic aging mice injected with D-galactose. Our findings demonstrated that 48 mRNAs were differentially expressed between control and D-galactose mice, and 51 potential biomarkers were identified at the metabolic level. The effects of D-galactose on aging could be attributed to glucose and 1ipid metabolic disorders, oxidative damage, accumulation of advanced glycation end products (AGEs), reduction in abnormal substance elimination, cell apoptosis, and insulin resistance.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0132088</identifier><identifier>PMID: 26176541</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Advanced glycosylation end products ; Age ; Aging ; Aging (artificial) ; Aging - genetics ; Animals ; Apoptosis ; Aquaculture ; Autophagy ; Biomarkers ; Biomarkers - metabolism ; Biotechnology ; Collaboration ; D-Galactose ; Damage accumulation ; Diabetes ; Disorders ; Education ; Efficiency ; Galactose ; Galactose - pharmacology ; Gas chromatography ; Gas Chromatography-Mass Spectrometry ; Gene expression ; Glucose ; Glycosylation ; Insulin ; Insulin resistance ; Kinases ; Laboratories ; Lipids ; Liver - drug effects ; Liver - metabolism ; Mass spectrometry ; Mass spectroscopy ; Metabolic disorders ; Metabolism ; Metabolites ; Metabolome - drug effects ; Metabolomics ; Mice ; Mice, Inbred ICR ; Multivariate Analysis ; Oligonucleotide Array Sequence Analysis ; Oxidative stress ; Pharmacology ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents ; Studies ; Transcription ; Transcription, Genetic - drug effects</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0132088-e0132088</ispartof><rights>2015 Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Zhou et al 2015 Zhou et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-92e6ee5b07ae559a9894e432b1c30651ca1e4c97aacf0fc7e9c5a1e8b7d90e143</citedby><cites>FETCH-LOGICAL-c526t-92e6ee5b07ae559a9894e432b1c30651ca1e4c97aacf0fc7e9c5a1e8b7d90e143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503422/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503422/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26176541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Yue-Yue</creatorcontrib><creatorcontrib>Ji, Xiong-Fei</creatorcontrib><creatorcontrib>Fu, Jian-Ping</creatorcontrib><creatorcontrib>Zhu, Xiao-Juan</creatorcontrib><creatorcontrib>Li, Rong-Hua</creatorcontrib><creatorcontrib>Mu, Chang-Kao</creatorcontrib><creatorcontrib>Wang, Chun-Lin</creatorcontrib><creatorcontrib>Song, Wei-Wei</creatorcontrib><title>Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>D-galactose injection has been shown to induce many changes in mice that represent accelerated aging. This mouse model has been widely used for pharmacological studies of anti-aging agents. The underlying mechanism of D-galactose induced aging remains unclear, however, it appears to relate to glucose and 1ipid metabolic disorders. Currently, there has yet to be a study that focuses on investigating gene expression changes in D-galactose aging mice. In this study, integrated analysis of gas chromatography/mass spectrometry-based metabonomics and gene expression profiles was used to investigate the changes in transcriptional and metabolic profiles in mimetic aging mice injected with D-galactose. Our findings demonstrated that 48 mRNAs were differentially expressed between control and D-galactose mice, and 51 potential biomarkers were identified at the metabolic level. The effects of D-galactose on aging could be attributed to glucose and 1ipid metabolic disorders, oxidative damage, accumulation of advanced glycation end products (AGEs), reduction in abnormal substance elimination, cell apoptosis, and insulin resistance.</description><subject>Advanced glycosylation end products</subject><subject>Age</subject><subject>Aging</subject><subject>Aging (artificial)</subject><subject>Aging - genetics</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Aquaculture</subject><subject>Autophagy</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Biotechnology</subject><subject>Collaboration</subject><subject>D-Galactose</subject><subject>Damage accumulation</subject><subject>Diabetes</subject><subject>Disorders</subject><subject>Education</subject><subject>Efficiency</subject><subject>Galactose</subject><subject>Galactose - pharmacology</subject><subject>Gas chromatography</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Gene expression</subject><subject>Glucose</subject><subject>Glycosylation</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Lipids</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolome - drug effects</subject><subject>Metabolomics</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Multivariate Analysis</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oxidative stress</subject><subject>Pharmacology</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Reproducibility of Results</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>Studies</subject><subject>Transcription</subject><subject>Transcription, Genetic - drug effects</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAQjRCIloV_gCASFy5Z_J34glQtsKzUCg7lbI2dSepV1l7sLFL_PdluWrWIk-2ZN2_es15RvKVkSXlNP23jIQUYlvsYcEkoZ6RpnhXnVHNWKUb480f3s-JVzltCJG-UelmcMUVrJQU9L8waA5bXCUJ2ye9HHyfOEkJbXuEINg7elT9T7PyA5eoGQo-59KG88jscp9ZF70M_vRyWm9AeHLalvS2_VGsYwI0x4-viRQdDxjfzuSh-fft6vfpeXf5Yb1YXl5WTTI2VZqgQpSU1oJQadKMFCs4sdZwoSR1QFE7XAK4jnatROzmVGlu3miAVfFG8P_Huh5jN_DfZUKWVajSTbEJsTog2wtbsk99BujURvLkrxNQbSJOnAY1tGOOWdxwIEVxbwJoit5KIrukkayeuz_O2g91h6zCMCYYnpE87wd-YPv4xQhIu2FHMx5kgxd8HzKPZ-exwGCBgPNzprmsp1QRfFB_-gf7fnTihXIo5J-wexFBijnm5nzLHvJg5L9PYu8dGHobuA8L_Am7pvjg</recordid><startdate>20150715</startdate><enddate>20150715</enddate><creator>Zhou, Yue-Yue</creator><creator>Ji, Xiong-Fei</creator><creator>Fu, Jian-Ping</creator><creator>Zhu, Xiao-Juan</creator><creator>Li, Rong-Hua</creator><creator>Mu, Chang-Kao</creator><creator>Wang, Chun-Lin</creator><creator>Song, Wei-Wei</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150715</creationdate><title>Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose</title><author>Zhou, Yue-Yue ; Ji, Xiong-Fei ; Fu, Jian-Ping ; Zhu, Xiao-Juan ; Li, Rong-Hua ; Mu, Chang-Kao ; Wang, Chun-Lin ; Song, Wei-Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-92e6ee5b07ae559a9894e432b1c30651ca1e4c97aacf0fc7e9c5a1e8b7d90e143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Advanced glycosylation end products</topic><topic>Age</topic><topic>Aging</topic><topic>Aging (artificial)</topic><topic>Aging - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Yue-Yue</au><au>Ji, Xiong-Fei</au><au>Fu, Jian-Ping</au><au>Zhu, Xiao-Juan</au><au>Li, Rong-Hua</au><au>Mu, Chang-Kao</au><au>Wang, Chun-Lin</au><au>Song, Wei-Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-15</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0132088</spage><epage>e0132088</epage><pages>e0132088-e0132088</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>D-galactose injection has been shown to induce many changes in mice that represent accelerated aging. This mouse model has been widely used for pharmacological studies of anti-aging agents. The underlying mechanism of D-galactose induced aging remains unclear, however, it appears to relate to glucose and 1ipid metabolic disorders. Currently, there has yet to be a study that focuses on investigating gene expression changes in D-galactose aging mice. In this study, integrated analysis of gas chromatography/mass spectrometry-based metabonomics and gene expression profiles was used to investigate the changes in transcriptional and metabolic profiles in mimetic aging mice injected with D-galactose. Our findings demonstrated that 48 mRNAs were differentially expressed between control and D-galactose mice, and 51 potential biomarkers were identified at the metabolic level. The effects of D-galactose on aging could be attributed to glucose and 1ipid metabolic disorders, oxidative damage, accumulation of advanced glycation end products (AGEs), reduction in abnormal substance elimination, cell apoptosis, and insulin resistance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26176541</pmid><doi>10.1371/journal.pone.0132088</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Advanced glycosylation end products Age Aging Aging (artificial) Aging - genetics Animals Apoptosis Aquaculture Autophagy Biomarkers Biomarkers - metabolism Biotechnology Collaboration D-Galactose Damage accumulation Diabetes Disorders Education Efficiency Galactose Galactose - pharmacology Gas chromatography Gas Chromatography-Mass Spectrometry Gene expression Glucose Glycosylation Insulin Insulin resistance Kinases Laboratories Lipids Liver - drug effects Liver - metabolism Mass spectrometry Mass spectroscopy Metabolic disorders Metabolism Metabolites Metabolome - drug effects Metabolomics Mice Mice, Inbred ICR Multivariate Analysis Oligonucleotide Array Sequence Analysis Oxidative stress Pharmacology Real-Time Polymerase Chain Reaction Reproducibility of Results RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Studies Transcription Transcription, Genetic - drug effects |
| title | Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose |
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