SIRT1 Interacts with and Deacetylates ATP6V1B2 in Mature Adipocytes

SIRT1 plays a key role in maintaining metabolic homeostasis in mammals by directly modulating the activities of various transcription factors and metabolic enzymes through lysine deacetylation. White adipose tissue plays a key role in lipid storage and metabolism. To identify novel molecular targets...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0133448-e0133448
Hauptverfasser:	Kim, Sun-Yee, Zhang, Qiongyi, Brunmeir, Reinhard, Han, Weiping, Xu, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Acetylation Adenosine triphosphatase Adipocytes Adipocytes - cytology Adipocytes - metabolism Adipose tissue Animals ATPases Biochemistry Cell cycle Cell Differentiation Chromatin Deacetylation Enzymes Fatty acids Gene expression HEK293 Cells Homeostasis Humans Hydrogen Immunoprecipitation In vivo methods and tests Lipid metabolism Lysine Mammals Metabolism Mice Physiological aspects Protein Binding Proteins Proteomics Science SIRT1 protein Sirtuin 1 - metabolism Target recognition Transcription factors Vacuolar Proton-Translocating ATPases - metabolism
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