Identification of Two Novel HOXB13 Germline Mutations in Portuguese Prostate Cancer Patients

The HOXB13 germline variant G84E (rs138213197) was recently described in men of European descent, with the highest prevalence in Northern Europe. The G84E mutation has not been found in patients of African or Asian ancestry, which may carry other HOXB13 variants, indicating allelic heterogeneity dep...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132728
Hauptverfasser:	Maia, Sofia, Cardoso, Marta, Pinto, Pedro, Pinheiro, Manuela, Santos, Catarina, Peixoto, Ana, Bento, Maria José, Oliveira, Jorge, Henrique, Rui, Jerónimo, Carmen, Teixeira, Manuel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - epidemiology Adenocarcinoma - genetics Adult Age Aged Amino Acid Sequence Androgens Base Sequence Cancer Cancer patients Carcinogenesis Carcinogens Care and treatment Case-Control Studies Deoxyribonucleic acid DNA DNA Mutational Analysis Epigenetics Ethnic factors Gene Frequency Gene mutation Genetic aspects Genetic Predisposition to Disease Genotype Genotyping Germ-Line Mutation Health risk assessment Homeodomain Proteins - genetics Hoxb13 gene Humans Male Medical diagnosis Middle Aged Minority & ethnic groups Molecular Sequence Data Mutation Patients Pedigree Portugal Predictive control Prevalence Prostate cancer Prostate carcinoma Prostatic Neoplasms - epidemiology Prostatic Neoplasms - genetics Risk Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!