Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population
The identification of susceptibility genes for specific types of cancer can provide necessary information for the complete characterization of cancer syndromes. Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and rs13042395,...
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description | The identification of susceptibility genes for specific types of cancer can provide necessary information for the complete characterization of cancer syndromes. Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and rs13042395, were reported by genome wide association studies (GWASs) to be closely related to the susceptibility of lung cancer (LC), gastric cancer (GC) or esophageal cancer (EC) in Han population from northern or southern China. However, Chinese Han people from different geographic areas may have different genetic backgrounds. This study aims to assess the genetic associations of the eight SNPs mentioned above with three cancers risk in a Han population from northwest China.
A total of 186 cancer-free controls and 436 cases with non-small cell lung cancer (NSCLC) (159 cases), non-cardia GC (167 cases) or EC (110 cases) were enrolled in this study. Chi-square test and polytomous logistic regression analyses were used to estimate the association between eight cancer-related SNPs and three cancers in a Han Chinese population from northwest China. The logistic regression results were adjusted for confounding factors and Benjamini and Hochberg False Discovery Rate (FDR) method was used to adjust the multiple hypothesis tests. Association analyses by cigarette smoking or alcohol drinking status were analyzed by crossover analyses.
One of the eight SNPs, rs17728461 was associated with NSCLC susceptibility (in a heterozygous model, OR = 0.44, 95% CI = 0.27-0.72, p = 0.001). Two SNPs, rs753955 and rs13042395, were associated with the risk of non-cardia GC in different genetic models (p < 0.05). No SNPs were associated with EC. The crossover analyses showed that the rs13042395 CT genotype, combined with cigarette smoking or alcohol drinking, could further increase the risk for non-cardia GC (p < 0.05).
These results indicated that rs17728461 may be specifically associated with the risk of NSCLC. rs753955 and rs13042395 were specifically associated with susceptibility to non-cardia GC in Ningxia Han Chinese. Susceptibility-associated polymorphisms in the northwestern Han Chinese were not very consistent with those in the northern Han Chinese or southern Han Chinese. The validation of these findings with a functional evaluation and a larger population is still required. |
doi_str_mv | 10.1371/journal.pone.0132797 |
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A total of 186 cancer-free controls and 436 cases with non-small cell lung cancer (NSCLC) (159 cases), non-cardia GC (167 cases) or EC (110 cases) were enrolled in this study. Chi-square test and polytomous logistic regression analyses were used to estimate the association between eight cancer-related SNPs and three cancers in a Han Chinese population from northwest China. The logistic regression results were adjusted for confounding factors and Benjamini and Hochberg False Discovery Rate (FDR) method was used to adjust the multiple hypothesis tests. Association analyses by cigarette smoking or alcohol drinking status were analyzed by crossover analyses.
One of the eight SNPs, rs17728461 was associated with NSCLC susceptibility (in a heterozygous model, OR = 0.44, 95% CI = 0.27-0.72, p = 0.001). Two SNPs, rs753955 and rs13042395, were associated with the risk of non-cardia GC in different genetic models (p < 0.05). No SNPs were associated with EC. The crossover analyses showed that the rs13042395 CT genotype, combined with cigarette smoking or alcohol drinking, could further increase the risk for non-cardia GC (p < 0.05).
These results indicated that rs17728461 may be specifically associated with the risk of NSCLC. rs753955 and rs13042395 were specifically associated with susceptibility to non-cardia GC in Ningxia Han Chinese. Susceptibility-associated polymorphisms in the northwestern Han Chinese were not very consistent with those in the northern Han Chinese or southern Han Chinese. The validation of these findings with a functional evaluation and a larger population is still required.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0132797</identifier><identifier>PMID: 26176862</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Alcohol ; Alcohol Drinking - adverse effects ; Alcohol use ; Alcohols ; Analysis ; Cancer ; Cancer therapies ; Carcinoma, Non-Small-Cell Lung - genetics ; Case-Control Studies ; China ; Chromosomes ; Cigarette smoking ; Cigarettes ; Cross-Over Studies ; Deoxyribonucleic acid ; Disease prevention ; Disease susceptibility ; DNA ; Drinking behavior ; Esophageal cancer ; Esophageal Neoplasms - genetics ; Esophagus ; Female ; Gastric cancer ; Gene Frequency ; Genetic aspects ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetic testing ; Genomes ; Genomics ; Genotypes ; Health aspects ; Health risk assessment ; Health risks ; Humans ; Laboratories ; Lung cancer ; Lung diseases ; Lung Neoplasms - genetics ; Male ; Middle Aged ; Mitochondrial DNA ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Polymorphism, Single Nucleotide ; Population ; Regression analysis ; Risk ; Risk Factors ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Smoking ; Smoking - adverse effects ; Statistical tests ; Stomach cancer ; Stomach Neoplasms - genetics ; Studies</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0132797-e0132797</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Dong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Dong et al 2015 Dong et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ad63e4d55742742c6517d6be1ea95783150ea2487905a5f6c207d5d0fdc607da3</citedby><cites>FETCH-LOGICAL-c692t-ad63e4d55742742c6517d6be1ea95783150ea2487905a5f6c207d5d0fdc607da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503434/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503434/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26176862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Langevin, Scott M.</contributor><creatorcontrib>Dong, Ying</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Chen, Zhiqiang</creatorcontrib><creatorcontrib>Tian, Chaoyong</creatorcontrib><creatorcontrib>Lu, Huaisheng</creatorcontrib><creatorcontrib>Ruan, Jigang</creatorcontrib><creatorcontrib>Yang, Wenjun</creatorcontrib><title>Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The identification of susceptibility genes for specific types of cancer can provide necessary information for the complete characterization of cancer syndromes. Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and rs13042395, were reported by genome wide association studies (GWASs) to be closely related to the susceptibility of lung cancer (LC), gastric cancer (GC) or esophageal cancer (EC) in Han population from northern or southern China. However, Chinese Han people from different geographic areas may have different genetic backgrounds. This study aims to assess the genetic associations of the eight SNPs mentioned above with three cancers risk in a Han population from northwest China.
A total of 186 cancer-free controls and 436 cases with non-small cell lung cancer (NSCLC) (159 cases), non-cardia GC (167 cases) or EC (110 cases) were enrolled in this study. Chi-square test and polytomous logistic regression analyses were used to estimate the association between eight cancer-related SNPs and three cancers in a Han Chinese population from northwest China. The logistic regression results were adjusted for confounding factors and Benjamini and Hochberg False Discovery Rate (FDR) method was used to adjust the multiple hypothesis tests. Association analyses by cigarette smoking or alcohol drinking status were analyzed by crossover analyses.
One of the eight SNPs, rs17728461 was associated with NSCLC susceptibility (in a heterozygous model, OR = 0.44, 95% CI = 0.27-0.72, p = 0.001). Two SNPs, rs753955 and rs13042395, were associated with the risk of non-cardia GC in different genetic models (p < 0.05). No SNPs were associated with EC. The crossover analyses showed that the rs13042395 CT genotype, combined with cigarette smoking or alcohol drinking, could further increase the risk for non-cardia GC (p < 0.05).
These results indicated that rs17728461 may be specifically associated with the risk of NSCLC. rs753955 and rs13042395 were specifically associated with susceptibility to non-cardia GC in Ningxia Han Chinese. Susceptibility-associated polymorphisms in the northwestern Han Chinese were not very consistent with those in the northern Han Chinese or southern Han Chinese. The validation of these findings with a functional evaluation and a larger population is still required.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol use</subject><subject>Alcohols</subject><subject>Analysis</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Chromosomes</subject><subject>Cigarette smoking</subject><subject>Cigarettes</subject><subject>Cross-Over Studies</subject><subject>Deoxyribonucleic acid</subject><subject>Disease prevention</subject><subject>Disease susceptibility</subject><subject>DNA</subject><subject>Drinking behavior</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gene Frequency</subject><subject>Genetic aspects</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic testing</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Genotypes</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitochondrial DNA</subject><subject>Non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Regression analysis</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Statistical tests</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - genetics</subject><subject>Studies</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9GO1CAUhhujcdfRNzDaxMToxYxQCrQ3JpPJ6E6yyRpXvSWU0pYNhW6hq_P20pnuZmr2wkBSoN__Hzhwoug1BCuIKPx0Y4fecL3qrJErAFFCc_okOoc5SpYkAejpyfgseuHcDQAYZYQ8j84SAinJSHIeNds7rgfulalj38h47ZwVKsytiW0Vb1Xd-Pib1fvW9l2jXOvi38o38YYbIfv4enBCdl4VSiu_j5WJeXzBTbxplJFOBmU36IPby-hZxbWTr6bvIvr5Zftjc7G8vPq626wvl4LkiV_ykiCZlhjTNAldEAxpSQoJJc8xzRDEQPIkzWgOMMcVEQmgJS5BVQoSRhwtordH305bx6YkOQZJTkhGYUoCsTsSpeU3rOtVy_s9s1yxw4Lta8Z7r4SWTACJoJA8kzlOc8wLSJMirwQWhZA4BcHr8xRtKFpZCml8z_XMdP7HqIbV9o6lGKA0tEX0YTLo7e0gnWetCinVmhtph8O-KcUYoXHf7_5BHz_dRNU8HECZyoa4YjRl6zSBGUGAjGFXj1ChlbJVIryoSoX1meDjTBAYL__4mg_Osd319_9nr37N2fcnbCO59o2zehifjJuD6REUvXWul9VDkiFgY0HcZ4ONBcGmggiyN6cX9CC6rwD0F75lBi4</recordid><startdate>20150715</startdate><enddate>20150715</enddate><creator>Dong, Ying</creator><creator>Chen, Jing</creator><creator>Chen, Zhiqiang</creator><creator>Tian, Chaoyong</creator><creator>Lu, Huaisheng</creator><creator>Ruan, Jigang</creator><creator>Yang, Wenjun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150715</creationdate><title>Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population</title><author>Dong, Ying ; Chen, Jing ; Chen, Zhiqiang ; Tian, Chaoyong ; Lu, Huaisheng ; Ruan, Jigang ; Yang, Wenjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ad63e4d55742742c6517d6be1ea95783150ea2487905a5f6c207d5d0fdc607da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol use</topic><topic>Alcohols</topic><topic>Analysis</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Case-Control Studies</topic><topic>China</topic><topic>Chromosomes</topic><topic>Cigarette smoking</topic><topic>Cigarettes</topic><topic>Cross-Over Studies</topic><topic>Deoxyribonucleic acid</topic><topic>Disease prevention</topic><topic>Disease susceptibility</topic><topic>DNA</topic><topic>Drinking behavior</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gene Frequency</topic><topic>Genetic aspects</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic testing</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Genotypes</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitochondrial DNA</topic><topic>Non-small cell lung cancer</topic><topic>Non-small cell lung carcinoma</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Regression analysis</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Statistical tests</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - genetics</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Ying</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Chen, Zhiqiang</creatorcontrib><creatorcontrib>Tian, Chaoyong</creatorcontrib><creatorcontrib>Lu, Huaisheng</creatorcontrib><creatorcontrib>Ruan, Jigang</creatorcontrib><creatorcontrib>Yang, Wenjun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Ying</au><au>Chen, Jing</au><au>Chen, Zhiqiang</au><au>Tian, Chaoyong</au><au>Lu, Huaisheng</au><au>Ruan, Jigang</au><au>Yang, Wenjun</au><au>Langevin, Scott M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-15</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0132797</spage><epage>e0132797</epage><pages>e0132797-e0132797</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The identification of susceptibility genes for specific types of cancer can provide necessary information for the complete characterization of cancer syndromes. Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and rs13042395, were reported by genome wide association studies (GWASs) to be closely related to the susceptibility of lung cancer (LC), gastric cancer (GC) or esophageal cancer (EC) in Han population from northern or southern China. However, Chinese Han people from different geographic areas may have different genetic backgrounds. This study aims to assess the genetic associations of the eight SNPs mentioned above with three cancers risk in a Han population from northwest China.
A total of 186 cancer-free controls and 436 cases with non-small cell lung cancer (NSCLC) (159 cases), non-cardia GC (167 cases) or EC (110 cases) were enrolled in this study. Chi-square test and polytomous logistic regression analyses were used to estimate the association between eight cancer-related SNPs and three cancers in a Han Chinese population from northwest China. The logistic regression results were adjusted for confounding factors and Benjamini and Hochberg False Discovery Rate (FDR) method was used to adjust the multiple hypothesis tests. Association analyses by cigarette smoking or alcohol drinking status were analyzed by crossover analyses.
One of the eight SNPs, rs17728461 was associated with NSCLC susceptibility (in a heterozygous model, OR = 0.44, 95% CI = 0.27-0.72, p = 0.001). Two SNPs, rs753955 and rs13042395, were associated with the risk of non-cardia GC in different genetic models (p < 0.05). No SNPs were associated with EC. The crossover analyses showed that the rs13042395 CT genotype, combined with cigarette smoking or alcohol drinking, could further increase the risk for non-cardia GC (p < 0.05).
These results indicated that rs17728461 may be specifically associated with the risk of NSCLC. rs753955 and rs13042395 were specifically associated with susceptibility to non-cardia GC in Ningxia Han Chinese. Susceptibility-associated polymorphisms in the northwestern Han Chinese were not very consistent with those in the northern Han Chinese or southern Han Chinese. The validation of these findings with a functional evaluation and a larger population is still required.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26176862</pmid><doi>10.1371/journal.pone.0132797</doi><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2015-07, Vol.10 (7), p.e0132797-e0132797 |
issn | 1932-6203 1932-6203 |
language | eng |
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source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Adult Aged Alcohol Alcohol Drinking - adverse effects Alcohol use Alcohols Analysis Cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - genetics Case-Control Studies China Chromosomes Cigarette smoking Cigarettes Cross-Over Studies Deoxyribonucleic acid Disease prevention Disease susceptibility DNA Drinking behavior Esophageal cancer Esophageal Neoplasms - genetics Esophagus Female Gastric cancer Gene Frequency Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Genetic testing Genomes Genomics Genotypes Health aspects Health risk assessment Health risks Humans Laboratories Lung cancer Lung diseases Lung Neoplasms - genetics Male Middle Aged Mitochondrial DNA Non-small cell lung cancer Non-small cell lung carcinoma Polymorphism, Single Nucleotide Population Regression analysis Risk Risk Factors Single nucleotide polymorphisms Single-nucleotide polymorphism Smoking Smoking - adverse effects Statistical tests Stomach cancer Stomach Neoplasms - genetics Studies |
title | Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population |
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