Increased Acquired Cholesteatoma Risk in Patients with Osteoporosis: A Retrospective Cohort Study
Clinically, we found the increased incidence of acquired colesteatoma in the patients with osteoporosis. In this study, we used a retrospective cohort to examine this association and to investigate the possible mechanism. We conducted a population-based retrospective cohort study by using the Nation...
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| Veröffentlicht in: | PloS one 2015-07, Vol.10 (7), p.e0132447-e0132447 |
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| description | Clinically, we found the increased incidence of acquired colesteatoma in the patients with osteoporosis. In this study, we used a retrospective cohort to examine this association and to investigate the possible mechanism.
We conducted a population-based retrospective cohort study by using the National Health Insurance Research Database (NHIRD). We identified an osteoporosis cohort comprising 37 124 patients newly diagnosed with osteoporosis aged 20 years or older. Patients in the comparison cohort had no history of osteoporosis and were frequency matched with the patients in the osteoporosis cohort according to sex, age, and index year.
The acquired cholesteatoma incidence rates for the osteoporosis and comparison cohorts were 1.12 and 0.83 per 1000 person-years, respectively. After we adjusted for confounding factors, the osteoporosis cohort exhibited a 1.32-fold increased acquired cholesteatoma risk relative to the comparison cohort (hazard ratio [HR] = 1.32, 95% confidence interval [CI] = 1.11-1.57). In addition, patients with no history of otitis media (HR = 1.33, 95% CI = 1.11-1.59), cancer (HR = 1.34, 95% CI = 1.12-1.60), or COPD (HR = 1.26, 95% CI = 1.05-1.52) in the osteoporosis cohort exhibited an increased risk of subsequent acquired cholesteatoma relative to those in the comparison cohort.
Our cohort study indicated that patients with osteoporosis had a 1.31-fold increased acquired cholesteatoma risk relative to the comparison cohort. This risk was further increased in patients with comorbid otitis media. Hence, we recommend that otolaryngologists evaluate the condition of the middle ear of patients with osteoporosis. |
| doi_str_mv | 10.1371/journal.pone.0132447 |
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We conducted a population-based retrospective cohort study by using the National Health Insurance Research Database (NHIRD). We identified an osteoporosis cohort comprising 37 124 patients newly diagnosed with osteoporosis aged 20 years or older. Patients in the comparison cohort had no history of osteoporosis and were frequency matched with the patients in the osteoporosis cohort according to sex, age, and index year.
The acquired cholesteatoma incidence rates for the osteoporosis and comparison cohorts were 1.12 and 0.83 per 1000 person-years, respectively. After we adjusted for confounding factors, the osteoporosis cohort exhibited a 1.32-fold increased acquired cholesteatoma risk relative to the comparison cohort (hazard ratio [HR] = 1.32, 95% confidence interval [CI] = 1.11-1.57). In addition, patients with no history of otitis media (HR = 1.33, 95% CI = 1.11-1.59), cancer (HR = 1.34, 95% CI = 1.12-1.60), or COPD (HR = 1.26, 95% CI = 1.05-1.52) in the osteoporosis cohort exhibited an increased risk of subsequent acquired cholesteatoma relative to those in the comparison cohort.
Our cohort study indicated that patients with osteoporosis had a 1.31-fold increased acquired cholesteatoma risk relative to the comparison cohort. This risk was further increased in patients with comorbid otitis media. Hence, we recommend that otolaryngologists evaluate the condition of the middle ear of patients with osteoporosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0132447</identifier><identifier>PMID: 26171780</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Albinism ; Back pain ; Biocompatibility ; Cancer ; Cell cycle ; Cholesteatoma - complications ; Cholesteatoma - epidemiology ; Chronic obstructive pulmonary disease ; Cohort analysis ; Cohort Studies ; Confidence intervals ; Congenital diseases ; Cytokines ; Diabetes ; Ear diseases ; Eardrum ; Female ; Health insurance ; Hospitals ; Humans ; Incidence ; Male ; Medicine ; Middle Aged ; Middle ear ; Older people ; Osteoporosis ; Osteoporosis - complications ; Otitis media ; Otolaryngology ; Pathogenesis ; Patients ; Population studies ; Retrospective Studies ; Risk ; Risk Factors ; Studies ; Surgery ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0132447-e0132447</ispartof><rights>2015 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Wang et al 2015 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-3591d6a49c372d3f87b8116281e26e9f820af4d0d288ce4832dee78cc1fc600a3</citedby><cites>FETCH-LOGICAL-c526t-3591d6a49c372d3f87b8116281e26e9f820af4d0d288ce4832dee78cc1fc600a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501779/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501779/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26171780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Isales, Carlos M.</contributor><creatorcontrib>Wang, Tang-Chuan</creatorcontrib><creatorcontrib>Lin, Che-Chen</creatorcontrib><creatorcontrib>Lin, Chia-Der</creatorcontrib><creatorcontrib>Chung, Hsiung-Kwang</creatorcontrib><creatorcontrib>Wang, Ching-Yuang</creatorcontrib><creatorcontrib>Tsai, Ming-Hsui</creatorcontrib><creatorcontrib>Kao, Chia-Hung</creatorcontrib><title>Increased Acquired Cholesteatoma Risk in Patients with Osteoporosis: A Retrospective Cohort Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Clinically, we found the increased incidence of acquired colesteatoma in the patients with osteoporosis. In this study, we used a retrospective cohort to examine this association and to investigate the possible mechanism.
We conducted a population-based retrospective cohort study by using the National Health Insurance Research Database (NHIRD). We identified an osteoporosis cohort comprising 37 124 patients newly diagnosed with osteoporosis aged 20 years or older. Patients in the comparison cohort had no history of osteoporosis and were frequency matched with the patients in the osteoporosis cohort according to sex, age, and index year.
The acquired cholesteatoma incidence rates for the osteoporosis and comparison cohorts were 1.12 and 0.83 per 1000 person-years, respectively. After we adjusted for confounding factors, the osteoporosis cohort exhibited a 1.32-fold increased acquired cholesteatoma risk relative to the comparison cohort (hazard ratio [HR] = 1.32, 95% confidence interval [CI] = 1.11-1.57). In addition, patients with no history of otitis media (HR = 1.33, 95% CI = 1.11-1.59), cancer (HR = 1.34, 95% CI = 1.12-1.60), or COPD (HR = 1.26, 95% CI = 1.05-1.52) in the osteoporosis cohort exhibited an increased risk of subsequent acquired cholesteatoma relative to those in the comparison cohort.
Our cohort study indicated that patients with osteoporosis had a 1.31-fold increased acquired cholesteatoma risk relative to the comparison cohort. This risk was further increased in patients with comorbid otitis media. Hence, we recommend that otolaryngologists evaluate the condition of the middle ear of patients with osteoporosis.</description><subject>Aged</subject><subject>Albinism</subject><subject>Back pain</subject><subject>Biocompatibility</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Cholesteatoma - complications</subject><subject>Cholesteatoma - epidemiology</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Congenital diseases</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Ear diseases</subject><subject>Eardrum</subject><subject>Female</subject><subject>Health insurance</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Middle ear</subject><subject>Older people</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Otitis media</subject><subject>Otolaryngology</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Population studies</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Surgery</subject><subject>Tumor necrosis factor-TNF</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUtluEzEUHSEQXeAPEFjipS8J3sYLD0hRxBKpUlGBZ8vx0jhMxlPbU9S_x2mmVYt48pHvucf3Hp-meYPgHBGOPmzjmHrdzYfYuzlEBFPKnzXHSBI8YxiS54_wUXOS8xbClgjGXjZHmCGOuIDHjV71JjmdnQULcz2GVMFyEzuXi9Ml7jS4DPk3CD34rktwfcngTygbcFHrcYgp5pA_ggW4dKXiwZkSbhxYxk1MBfwoo7191bzwusvu9XSeNr--fP65_DY7v_i6Wi7OZ6bFrMxIK5FlmkpDOLbEC74WCDEskMPMSS8w1J5aaLEQxlFBsHWOC2OQNwxCTU6bdwfdoYtZTe5khZhkmGIpZGWsDgwb9VYNKex0ulVRB3V3EdOV0qkE0zmlIWWE-3UrrK--eg2ZNFp7Q1or5ZpXrU_Ta-N656ypziTdPRF9WunDRl3FG0VbiDjfD3M2CaR4PVa71S5k47pO9y6Od3NzjCiBtFLf_0P9_3b0wDL1I3Jy_mEYBNU-Mfddap8YNSWmtr19vMhD031EyF9Jn8A5</recordid><startdate>20150714</startdate><enddate>20150714</enddate><creator>Wang, Tang-Chuan</creator><creator>Lin, Che-Chen</creator><creator>Lin, Chia-Der</creator><creator>Chung, Hsiung-Kwang</creator><creator>Wang, Ching-Yuang</creator><creator>Tsai, Ming-Hsui</creator><creator>Kao, Chia-Hung</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150714</creationdate><title>Increased Acquired Cholesteatoma Risk in Patients with Osteoporosis: A Retrospective Cohort Study</title><author>Wang, Tang-Chuan ; Lin, Che-Chen ; Lin, Chia-Der ; Chung, Hsiung-Kwang ; Wang, Ching-Yuang ; Tsai, Ming-Hsui ; Kao, Chia-Hung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-3591d6a49c372d3f87b8116281e26e9f820af4d0d288ce4832dee78cc1fc600a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Albinism</topic><topic>Back pain</topic><topic>Biocompatibility</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>Cholesteatoma - complications</topic><topic>Cholesteatoma - epidemiology</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Confidence intervals</topic><topic>Congenital diseases</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Ear diseases</topic><topic>Eardrum</topic><topic>Female</topic><topic>Health insurance</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Middle ear</topic><topic>Older people</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Otitis media</topic><topic>Otolaryngology</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Population studies</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Surgery</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Tang-Chuan</creatorcontrib><creatorcontrib>Lin, Che-Chen</creatorcontrib><creatorcontrib>Lin, Chia-Der</creatorcontrib><creatorcontrib>Chung, Hsiung-Kwang</creatorcontrib><creatorcontrib>Wang, Ching-Yuang</creatorcontrib><creatorcontrib>Tsai, Ming-Hsui</creatorcontrib><creatorcontrib>Kao, Chia-Hung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Tang-Chuan</au><au>Lin, Che-Chen</au><au>Lin, Chia-Der</au><au>Chung, Hsiung-Kwang</au><au>Wang, Ching-Yuang</au><au>Tsai, Ming-Hsui</au><au>Kao, Chia-Hung</au><au>Isales, Carlos M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Acquired Cholesteatoma Risk in Patients with Osteoporosis: A Retrospective Cohort Study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-14</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0132447</spage><epage>e0132447</epage><pages>e0132447-e0132447</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Clinically, we found the increased incidence of acquired colesteatoma in the patients with osteoporosis. In this study, we used a retrospective cohort to examine this association and to investigate the possible mechanism.
We conducted a population-based retrospective cohort study by using the National Health Insurance Research Database (NHIRD). We identified an osteoporosis cohort comprising 37 124 patients newly diagnosed with osteoporosis aged 20 years or older. Patients in the comparison cohort had no history of osteoporosis and were frequency matched with the patients in the osteoporosis cohort according to sex, age, and index year.
The acquired cholesteatoma incidence rates for the osteoporosis and comparison cohorts were 1.12 and 0.83 per 1000 person-years, respectively. After we adjusted for confounding factors, the osteoporosis cohort exhibited a 1.32-fold increased acquired cholesteatoma risk relative to the comparison cohort (hazard ratio [HR] = 1.32, 95% confidence interval [CI] = 1.11-1.57). In addition, patients with no history of otitis media (HR = 1.33, 95% CI = 1.11-1.59), cancer (HR = 1.34, 95% CI = 1.12-1.60), or COPD (HR = 1.26, 95% CI = 1.05-1.52) in the osteoporosis cohort exhibited an increased risk of subsequent acquired cholesteatoma relative to those in the comparison cohort.
Our cohort study indicated that patients with osteoporosis had a 1.31-fold increased acquired cholesteatoma risk relative to the comparison cohort. This risk was further increased in patients with comorbid otitis media. Hence, we recommend that otolaryngologists evaluate the condition of the middle ear of patients with osteoporosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26171780</pmid><doi>10.1371/journal.pone.0132447</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Albinism Back pain Biocompatibility Cancer Cell cycle Cholesteatoma - complications Cholesteatoma - epidemiology Chronic obstructive pulmonary disease Cohort analysis Cohort Studies Confidence intervals Congenital diseases Cytokines Diabetes Ear diseases Eardrum Female Health insurance Hospitals Humans Incidence Male Medicine Middle Aged Middle ear Older people Osteoporosis Osteoporosis - complications Otitis media Otolaryngology Pathogenesis Patients Population studies Retrospective Studies Risk Risk Factors Studies Surgery Tumor necrosis factor-TNF |
| title | Increased Acquired Cholesteatoma Risk in Patients with Osteoporosis: A Retrospective Cohort Study |
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