The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart

5-Lipoxygenase (5-LO) catalyzes leukotriene (LT) biosynthesis by a mechanism that involves interactions with 5-lipoxygenase activating protein (FLAP) and coactosin-like protein (CLP). 5-LO splice variants were recently identified in human myeloid and lymphoid cells, including the catalytically inact...

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Veröffentlicht in:	PloS one 2015, Vol.10 (7), p.e0132607-e0132607
Hauptverfasser:	Allain, Eric P, Boudreau, Luc H, Flamand, Nicolas, Surette, Marc E
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Lipoxygenase-Activating Proteins - metabolism Alternative Splicing Amino Acid Substitution Amino acids Arachidonate 5-lipoxygenase Arachidonate 5-Lipoxygenase - chemistry Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism Binding Sites - genetics Biosynthesis Brain cancer Confocal microscopy Enzymes HEK293 Cells Humans Hydroxyeicosatetraenoic Acids - biosynthesis Inhibition Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - metabolism Isoforms Kinases Leukotrienes - biosynthesis Lipoxygenase Localization Lymphoid cells Microfilament Proteins - metabolism Microscopy Microscopy, Confocal Mutagenesis, Site-Directed Mutants Neutrophils Phosphorylation Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Rodents Subcellular Fractions - enzymology Transcription Tryptophan Tumors
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