Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice

Precise understanding of radiation effects is critical to develop new modalities for the prevention and treatment of radiation-induced damage. We previously reported that non-lethal doses of X-ray irradiation induce DNA damage in human hematopoietic stem and progenitor cells (HSPCs) reconstituted in...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132041-e0132041
Hauptverfasser:	Wang, Changshan, Oshima, Motohiko, Sashida, Goro, Tomioka, Takahisa, Hasegawa, Nagisa, Mochizuki-Kashio, Makiko, Nakajima-Takagi, Yaeko, Kusunoki, Yoichiro, Kyoizumi, Seishi, Imai, Kazue, Nakachi, Kei, Iwama, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - physiology Analysis Animals B cells B-Lymphocytes - metabolism B-Lymphocytes - radiation effects BASIC BIOLOGICAL SCIENCES Blood Blood cells Bone marrow CD19 antigen CD34 antigen Cell culture Cell Differentiation - radiation effects cell diffusion Cells (biology) Cord blood Damage prevention Deoxyribonucleic acid DNA DNA damage DNA repair Drug dosages Epidemiology Gene Expression Regulation - radiation effects Hematopoiesis - radiation effects Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - radiation effects Humans Immunodeficiency Ionizing radiation Irradiation Lymphocytes Lymphocytes B Medicine Mice Mice, Inbred NOD Mice, SCID mouse models Peripheral blood Phenotype Post-irradiation Progenitor cells Radiation Radiation damage Radiation effects Radiation, Ionizing regulator genes Repopulation Rodents Senescence Stem cells Stromal cells Transplantation X ray irradiation X-rays
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