Tacrolimus Protects Podocytes from Injury in Lupus Nephritis Partly by Stabilizing the Cytoskeleton and Inhibiting Podocyte Apoptosis

Several studies have reported that tacrolimus (TAC) significantly reduced proteinuria in lupus nephritis (LN) patients and mouse models. However, the mechanism for this effect remains undetermined. This study explored the mechanism of how TAC protects podocytes from injury to identify new targets fo...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132724-e0132724
Hauptverfasser:	Liao, Ruyi, Liu, Qinghua, Zheng, Zhihua, Fan, Jinjin, Peng, Wenxing, Kong, Qingyu, He, Huijuan, Yang, Shicong, Chen, Wenfang, Tang, Xueqing, Yu, Xueqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Analysis Animal models Animals Annexin V Apoptosis Arthritis Autoimmune diseases Blood Bone morphogenetic proteins Cell Line Complement C3 - metabolism Confocal microscopy Creatinine Cytometry Cytoprotection Cytoskeleton Cytoskeleton - drug effects Cytoskeleton - pathology Deposition Disease control Drug Evaluation, Preclinical Electron microscopy Feet Female Flow cytometry Gene expression Growth factors Hospitals Identification methods Imines Immunofluorescence Immunoglobulin G Immunoglobulin G - metabolism Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Injuries Kidney - drug effects Kidney - pathology Kidney - physiopathology Laboratories Lupus Lupus nephritis Lupus Nephritis - drug therapy Lupus Nephritis - metabolism Lupus Nephritis - pathology Mice Mice, Inbred MRL lpr Microfilament Proteins - metabolism mRNA Nephritis Nephrology Pathology Podocytes - drug effects Podocytes - physiology Protein Stability Proteins Proteinuria Proteinuria - drug therapy Proteinuria - metabolism Renal function RNA Rodents Schiff bases Systemic lupus erythematosus Tacrolimus Tacrolimus - pharmacokinetics Tacrolimus - therapeutic use Target recognition Transforming growth factor-b1 Transforming growth factors Transmission electron microscopy Urea Urine Western blotting
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