Flot-2 Expression Correlates with EGFR Levels and Poor Prognosis in Surgically Resected Non-Small Cell Lung Cancer

We previously reported that expression of Flotillin 2 (Flot-2), a protein isolated from caveolae/lipid raft domains, increased significantly in nasopharyngeal carcinoma (NPC) compared with normal tissues. Signal transduction through epidermal growth factor receptors (EGFR) and Flot-2 play an importa...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132190-e0132190
Hauptverfasser:	Wen, Qiuyuan, Wang, Weiyuan, Chu, Shuzhou, Luo, Jiadi, Chen, Lingjiao, Xie, Guiyuan, Xu, Lina, Li, Meirong, Fan, Songqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - surgery Biomarkers Cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Caveolae Cellular signal transduction Correlation analysis Epidermal growth factor Epidermal growth factor receptors Ethics Female Gastric cancer Growth factor receptors Humans Immunohistochemistry Kaplan-Meier Estimate Kinases Lung cancer Lung diseases Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - surgery Lymphatic system Male Medical prognosis Membrane Proteins - metabolism Metastasis Middle Aged Multivariate Analysis Nasopharyngeal carcinoma Non-small cell lung cancer Non-small cell lung carcinoma Pathology Patients Prognosis Proportional Hazards Models Proteins Receptor, Epidermal Growth Factor - metabolism Receptors Small cell lung cancer Stomach cancer Survival Thoracic surgery Throat cancer Tissues Transduction Tumors
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