Simulated Microgravity Exerts an Age-Dependent Effect on the Differentiation of Cardiovascular Progenitors Isolated from the Human Heart

Microgravity has a profound effect on cardiovascular function, however, little is known about the impact of microgravity on progenitors that reside within the heart. We investigated the effect of simulated microgravity exposure on progenitors isolated from the neonatal and adult human heart by quant...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132378-e0132378
Hauptverfasser:	Fuentes, Tania I, Appleby, Nancy, Raya, Michael, Bailey, Leonard, Hasaniya, Nahidh, Stodieck, Louis, Kearns-Jonker, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Age Aged Aging - physiology AKT protein Angiogenesis Biomarkers Calcium-binding protein Cancer Cardiomyocytes Cardiovascular system Cell Count Cell cycle Cell differentiation Cell Differentiation - drug effects Cell growth Cell migration Cell Movement - drug effects Cell Separation - methods Clinorotation Cloning Deoxyribonucleic acid Differentiation (biology) DNA DNA repair DNA Repair - genetics Embryos Endothelial cells Exposure Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Flow cytometry Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Heart Heart diseases Heart surgery Humans Infant, Newborn Intercellular Signaling Peptides and Proteins - pharmacology Medicine Microgravity MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Myocardium - cytology Neonates Oct-4 protein Paracrine signalling Pathology Phosphorylation Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA-directed DNA polymerase Simulation Stem cells Stem Cells - cytology Stem Cells - drug effects Stem Cells - enzymology Telomerase Telomerase reverse transcriptase Troponin Troponin T Von Willebrand factor Weightlessness Simulation
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