The Diagnostic Accuracy of the M2 Pyruvate Kinase Quick Stool Test--A Rapid Office Based Assay Test for the Detection of Colorectal Cancer
M2 pyruvate kinase (M2PK) is an oncoprotein secreted by colorectal cancers in stools. This the first report on the accuracy of a rapid stool test in the detection of colorectal cancer (CRC). To determine the sensitivity, specificity and positive and negative predictive value of a rapid, point of car...
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| creator | Sithambaram, Suresh Hilmi, Ida Goh, Khean-Lee |
| description | M2 pyruvate kinase (M2PK) is an oncoprotein secreted by colorectal cancers in stools. This the first report on the accuracy of a rapid stool test in the detection of colorectal cancer (CRC).
To determine the sensitivity, specificity and positive and negative predictive value of a rapid, point of care stool test M2 PK- the M2PK Quick.
Consecutive cases of endoscopically diagnosed and histological proven CRC were recruited. Stools were collected by patients and tested with the immunochromatographic M2PK Quick Test (Schebo Biotech AC, Giessen, Germany). Controls were consecutively chosen from patients without any significant colorectal or gastrointestinal disease undergoing colonoscopy. CRC was staged according to the AJCC staging manual (7th Edition) and location of tumor defined as proximal or distal.
The sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were: 93%, 97.5%, 94.9%, 96.5% and 96.0% respectively. The positive predictive value for proximal tumors was significantly lower compared to distal tumors. No differences were seen between the different stages of the tumor.
The M2-PK Quick, rapid, point-of-care test is a highly accurate test in the detection of CRC. It is easy and convenient to perform and a useful diagnostic test for the detection of CRC in a clinical practice setting. |
| doi_str_mv | 10.1371/journal.pone.0131616 |
| format | Article |
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To determine the sensitivity, specificity and positive and negative predictive value of a rapid, point of care stool test M2 PK- the M2PK Quick.
Consecutive cases of endoscopically diagnosed and histological proven CRC were recruited. Stools were collected by patients and tested with the immunochromatographic M2PK Quick Test (Schebo Biotech AC, Giessen, Germany). Controls were consecutively chosen from patients without any significant colorectal or gastrointestinal disease undergoing colonoscopy. CRC was staged according to the AJCC staging manual (7th Edition) and location of tumor defined as proximal or distal.
The sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were: 93%, 97.5%, 94.9%, 96.5% and 96.0% respectively. The positive predictive value for proximal tumors was significantly lower compared to distal tumors. No differences were seen between the different stages of the tumor.
The M2-PK Quick, rapid, point-of-care test is a highly accurate test in the detection of CRC. It is easy and convenient to perform and a useful diagnostic test for the detection of CRC in a clinical practice setting.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0131616</identifier><identifier>PMID: 26158845</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accuracy ; Aged ; Biomarkers, Tumor - metabolism ; Biomedical laboratory equipment ; Cancer ; Cancer diagnosis ; Colon ; Colonoscopy ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - enzymology ; Committees ; Consent ; Diagnostic systems ; Feces ; Feces - enzymology ; Female ; Gastroenterology ; Hepatology ; Humans ; Male ; Medical diagnosis ; Medical screening ; Medical tests ; Middle Aged ; Neoplasm Staging ; Patients ; Point-of-Care Systems ; Predictive Value of Tests ; Pyruvate kinase ; Pyruvate Kinase - metabolism ; Pyruvic acid ; Sensitivity ; Sensitivity and Specificity ; Statistical analysis ; Tumors</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0131616-e0131616</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Sithambaram et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Sithambaram et al 2015 Sithambaram et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-aae7506e9c0718ba22d8e643c591a7ff310491343f39aaf4225399a7c37a457b3</citedby><cites>FETCH-LOGICAL-c692t-aae7506e9c0718ba22d8e643c591a7ff310491343f39aaf4225399a7c37a457b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497640/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497640/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26158845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zhang, Lanjing</contributor><creatorcontrib>Sithambaram, Suresh</creatorcontrib><creatorcontrib>Hilmi, Ida</creatorcontrib><creatorcontrib>Goh, Khean-Lee</creatorcontrib><title>The Diagnostic Accuracy of the M2 Pyruvate Kinase Quick Stool Test--A Rapid Office Based Assay Test for the Detection of Colorectal Cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>M2 pyruvate kinase (M2PK) is an oncoprotein secreted by colorectal cancers in stools. This the first report on the accuracy of a rapid stool test in the detection of colorectal cancer (CRC).
To determine the sensitivity, specificity and positive and negative predictive value of a rapid, point of care stool test M2 PK- the M2PK Quick.
Consecutive cases of endoscopically diagnosed and histological proven CRC were recruited. Stools were collected by patients and tested with the immunochromatographic M2PK Quick Test (Schebo Biotech AC, Giessen, Germany). Controls were consecutively chosen from patients without any significant colorectal or gastrointestinal disease undergoing colonoscopy. CRC was staged according to the AJCC staging manual (7th Edition) and location of tumor defined as proximal or distal.
The sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were: 93%, 97.5%, 94.9%, 96.5% and 96.0% respectively. The positive predictive value for proximal tumors was significantly lower compared to distal tumors. No differences were seen between the different stages of the tumor.
The M2-PK Quick, rapid, point-of-care test is a highly accurate test in the detection of CRC. It is easy and convenient to perform and a useful diagnostic test for the detection of CRC in a clinical practice setting.</description><subject>Accuracy</subject><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical laboratory equipment</subject><subject>Cancer</subject><subject>Cancer diagnosis</subject><subject>Colon</subject><subject>Colonoscopy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - enzymology</subject><subject>Committees</subject><subject>Consent</subject><subject>Diagnostic systems</subject><subject>Feces</subject><subject>Feces - enzymology</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical screening</subject><subject>Medical tests</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Patients</subject><subject>Point-of-Care Systems</subject><subject>Predictive Value of Tests</subject><subject>Pyruvate kinase</subject><subject>Pyruvate Kinase - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sithambaram, Suresh</au><au>Hilmi, Ida</au><au>Goh, Khean-Lee</au><au>Zhang, Lanjing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Diagnostic Accuracy of the M2 Pyruvate Kinase Quick Stool Test--A Rapid Office Based Assay Test for the Detection of Colorectal Cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-09</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0131616</spage><epage>e0131616</epage><pages>e0131616-e0131616</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>M2 pyruvate kinase (M2PK) is an oncoprotein secreted by colorectal cancers in stools. This the first report on the accuracy of a rapid stool test in the detection of colorectal cancer (CRC).
To determine the sensitivity, specificity and positive and negative predictive value of a rapid, point of care stool test M2 PK- the M2PK Quick.
Consecutive cases of endoscopically diagnosed and histological proven CRC were recruited. Stools were collected by patients and tested with the immunochromatographic M2PK Quick Test (Schebo Biotech AC, Giessen, Germany). Controls were consecutively chosen from patients without any significant colorectal or gastrointestinal disease undergoing colonoscopy. CRC was staged according to the AJCC staging manual (7th Edition) and location of tumor defined as proximal or distal.
The sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy were: 93%, 97.5%, 94.9%, 96.5% and 96.0% respectively. The positive predictive value for proximal tumors was significantly lower compared to distal tumors. No differences were seen between the different stages of the tumor.
The M2-PK Quick, rapid, point-of-care test is a highly accurate test in the detection of CRC. It is easy and convenient to perform and a useful diagnostic test for the detection of CRC in a clinical practice setting.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26158845</pmid><doi>10.1371/journal.pone.0131616</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Accuracy Aged Biomarkers, Tumor - metabolism Biomedical laboratory equipment Cancer Cancer diagnosis Colon Colonoscopy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - enzymology Committees Consent Diagnostic systems Feces Feces - enzymology Female Gastroenterology Hepatology Humans Male Medical diagnosis Medical screening Medical tests Middle Aged Neoplasm Staging Patients Point-of-Care Systems Predictive Value of Tests Pyruvate kinase Pyruvate Kinase - metabolism Pyruvic acid Sensitivity Sensitivity and Specificity Statistical analysis Tumors |
| title | The Diagnostic Accuracy of the M2 Pyruvate Kinase Quick Stool Test--A Rapid Office Based Assay Test for the Detection of Colorectal Cancer |
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