The Quinovic Acid Glycosides Purified Fraction from Uncaria tomentosa Protects against Hemorrhagic Cystitis Induced by Cyclophosphamide in Mice
Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate...
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| creator | Dietrich, Fabrícia Pietrobon Martins, Jerônimo Kaiser, Samuel Madeira Silva, Rodrigo Braccini Rockenbach, Liliana Albano Edelweiss, Maria Isabel Ortega, George González Morrone, Fernanda Bueno Campos, Maria Martha Battastini, Ana Maria Oliveira |
| description | Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been used to prevent the occurrence of HE, although this compound is not effective in established lesions. It has been demonstrated that the purinergic system is involved in several pathophysiological events. Among purinergic receptors, P2X7 deserves attention because it is involved in HE induced by CYP and, therefore, can be considered a therapeutic target. The objective of this study was to investigate the potential therapeutic effect of the quinovic acid glycosides purified fraction (QAPF) from U. tomentosa in the mouse model of CYP-induced HE. Pretreatment with QAPF not only had a protective effect on HE-induced urothelial damage (edema, hemorrhage and bladder wet weight) but was also able to control visceral pain, decrease IL-1β levels and down-regulates P2X7 receptors, most likely by inhibit the neutrophils migration to the bladder. This research clearly demonstrates the promising anti-inflammatory properties of QAPF, supporting its use as complementary therapy. QAPF represents a promising therapeutic option for this pathological condition. |
| doi_str_mv | 10.1371/journal.pone.0131882 |
| format | Article |
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Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been used to prevent the occurrence of HE, although this compound is not effective in established lesions. It has been demonstrated that the purinergic system is involved in several pathophysiological events. Among purinergic receptors, P2X7 deserves attention because it is involved in HE induced by CYP and, therefore, can be considered a therapeutic target. The objective of this study was to investigate the potential therapeutic effect of the quinovic acid glycosides purified fraction (QAPF) from U. tomentosa in the mouse model of CYP-induced HE. Pretreatment with QAPF not only had a protective effect on HE-induced urothelial damage (edema, hemorrhage and bladder wet weight) but was also able to control visceral pain, decrease IL-1β levels and down-regulates P2X7 receptors, most likely by inhibit the neutrophils migration to the bladder. This research clearly demonstrates the promising anti-inflammatory properties of QAPF, supporting its use as complementary therapy. QAPF represents a promising therapeutic option for this pathological condition.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0131882</identifier><identifier>PMID: 26154141</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Animals ; Anti-inflammatory agents ; Antineoplastic drugs ; Antitumor agents ; Behavior, Animal ; Bladder ; Cat's Claw - chemistry ; Cyclophosphamide ; Cyclophosphamide - adverse effects ; Cystitis ; Cystitis - chemically induced ; Cystitis - complications ; Cystitis - drug therapy ; Cystitis - physiopathology ; Cytochrome P-450 ; Disease ; Drug development ; Drugs ; Edema ; Glycosides ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Glycosides - therapeutic use ; Health aspects ; Hemorrhage ; Hemorrhage - chemically induced ; Hemorrhage - complications ; Hemorrhage - drug therapy ; Hemorrhage - physiopathology ; Hemorrhagic cystitis ; IL-1β ; Inflammation ; Interleukin-1beta - metabolism ; Lesions ; Leukocyte migration ; Leukocytes (neutrophilic) ; Male ; Medical treatment ; Mice ; Nociception - drug effects ; Pain ; Peroxidase - metabolism ; Protective Agents - pharmacology ; Protective Agents - therapeutic use ; Purine receptors ; Receptors ; Receptors, Purinergic P2X7 - metabolism ; Rodents ; Sodium ; Sodium 2-mercaptoethanesulfonate ; Stability ; Studies ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; Triterpenes - therapeutic use ; Uncaria tomentosa ; Urinary bladder ; Urinary Bladder - drug effects ; Urinary tract ; Viscera - drug effects</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0131882-e0131882</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Dietrich et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Dietrich et al 2015 Dietrich et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-fa9ab39c8f13fb1c0c08ff85a462a25a4e9c146c4afd450a37852566a51771d23</citedby><cites>FETCH-LOGICAL-c692t-fa9ab39c8f13fb1c0c08ff85a462a25a4e9c146c4afd450a37852566a51771d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496084/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496084/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26154141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Singh, Udai P.</contributor><creatorcontrib>Dietrich, Fabrícia</creatorcontrib><creatorcontrib>Pietrobon Martins, Jerônimo</creatorcontrib><creatorcontrib>Kaiser, Samuel</creatorcontrib><creatorcontrib>Madeira Silva, Rodrigo Braccini</creatorcontrib><creatorcontrib>Rockenbach, Liliana</creatorcontrib><creatorcontrib>Albano Edelweiss, Maria Isabel</creatorcontrib><creatorcontrib>Ortega, George González</creatorcontrib><creatorcontrib>Morrone, Fernanda Bueno</creatorcontrib><creatorcontrib>Campos, Maria Martha</creatorcontrib><creatorcontrib>Battastini, Ana Maria Oliveira</creatorcontrib><title>The Quinovic Acid Glycosides Purified Fraction from Uncaria tomentosa Protects against Hemorrhagic Cystitis Induced by Cyclophosphamide in Mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been used to prevent the occurrence of HE, although this compound is not effective in established lesions. It has been demonstrated that the purinergic system is involved in several pathophysiological events. Among purinergic receptors, P2X7 deserves attention because it is involved in HE induced by CYP and, therefore, can be considered a therapeutic target. The objective of this study was to investigate the potential therapeutic effect of the quinovic acid glycosides purified fraction (QAPF) from U. tomentosa in the mouse model of CYP-induced HE. Pretreatment with QAPF not only had a protective effect on HE-induced urothelial damage (edema, hemorrhage and bladder wet weight) but was also able to control visceral pain, decrease IL-1β levels and down-regulates P2X7 receptors, most likely by inhibit the neutrophils migration to the bladder. This research clearly demonstrates the promising anti-inflammatory properties of QAPF, supporting its use as complementary therapy. QAPF represents a promising therapeutic option for this pathological condition.</description><subject>Acids</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Antineoplastic drugs</subject><subject>Antitumor agents</subject><subject>Behavior, Animal</subject><subject>Bladder</subject><subject>Cat's Claw - chemistry</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Cystitis</subject><subject>Cystitis - chemically induced</subject><subject>Cystitis - complications</subject><subject>Cystitis - drug therapy</subject><subject>Cystitis - physiopathology</subject><subject>Cytochrome P-450</subject><subject>Disease</subject><subject>Drug development</subject><subject>Drugs</subject><subject>Edema</subject><subject>Glycosides</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Glycosides - therapeutic use</subject><subject>Health aspects</subject><subject>Hemorrhage</subject><subject>Hemorrhage - chemically induced</subject><subject>Hemorrhage - complications</subject><subject>Hemorrhage - drug therapy</subject><subject>Hemorrhage - physiopathology</subject><subject>Hemorrhagic cystitis</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukin-1beta - metabolism</subject><subject>Lesions</subject><subject>Leukocyte migration</subject><subject>Leukocytes (neutrophilic)</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Mice</subject><subject>Nociception - drug effects</subject><subject>Pain</subject><subject>Peroxidase - metabolism</subject><subject>Protective Agents - pharmacology</subject><subject>Protective Agents - therapeutic use</subject><subject>Purine receptors</subject><subject>Receptors</subject><subject>Receptors, Purinergic P2X7 - metabolism</subject><subject>Rodents</subject><subject>Sodium</subject><subject>Sodium 2-mercaptoethanesulfonate</subject><subject>Stability</subject><subject>Studies</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><subject>Triterpenes - therapeutic use</subject><subject>Uncaria tomentosa</subject><subject>Urinary bladder</subject><subject>Urinary Bladder - drug effects</subject><subject>Urinary tract</subject><subject>Viscera - drug effects</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9Fu0zAUhiMEYmPwBggsISG4aLFjx3VukKqKbZWGNmDj1jp17MZVEhfbmehT8Mq4aza1aBfIF7ZOvvMfnz8-Wfaa4DGhE_Jp5XrfQTNeu06PMaFEiPxJdkxKmo94junTvfNR9iKEFcYFFZw_z45yTgpGGDnO_lzXGn3rbedurUJTZSt01myUC7bSAV313hqrK3TqQUXrOmS8a9FNp8BbQNG1uosuALryLmoVA4Il2C5EdK5b530Ny6Q624Roow1o3lW9SmqLTYqpxq1rF9Y1tKkWsh36apV-mT0z0AT9athPspvTL9ez89HF5dl8Nr0YKV7mcWSghAUtlTCEmgVRWGFhjCiA8RzytOlSEcYVA1OxAgOdiCIvOIeCTCakyulJ9nanu25ckIOXQRJesrIQBONEzHdE5WAl19624DfSgZV3AeeXEny0qtFS6MSnApQyxmhJxKIUVZ4TzdKtODVJ6_NQrV-0ulLJNQ_Ngejhl87WculuJWMlx4IlgQ-DgHe_eh2ibG1Qummg066_u3fqTFBaJvTdP-jj3Q3UElIDtjMu1VVbUTllOcGUc7F1afwIlValW6vSwzM2xQ8SPh4kJCbq33EJfQhy_uP7_7OXPw_Z93tsraGJdXBNv32T4RBkO1B5F4LX5sFkguV2bu7dkNu5kcPcpLQ3-z_oIel-UOhfxEUTPg</recordid><startdate>20150708</startdate><enddate>20150708</enddate><creator>Dietrich, Fabrícia</creator><creator>Pietrobon Martins, Jerônimo</creator><creator>Kaiser, Samuel</creator><creator>Madeira Silva, Rodrigo Braccini</creator><creator>Rockenbach, Liliana</creator><creator>Albano Edelweiss, Maria Isabel</creator><creator>Ortega, George González</creator><creator>Morrone, Fernanda Bueno</creator><creator>Campos, Maria Martha</creator><creator>Battastini, Ana Maria Oliveira</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150708</creationdate><title>The Quinovic Acid Glycosides Purified Fraction from Uncaria tomentosa Protects against Hemorrhagic Cystitis Induced by Cyclophosphamide in Mice</title><author>Dietrich, Fabrícia ; Pietrobon Martins, Jerônimo ; Kaiser, Samuel ; Madeira Silva, Rodrigo Braccini ; Rockenbach, Liliana ; Albano Edelweiss, Maria Isabel ; Ortega, George González ; Morrone, Fernanda Bueno ; Campos, Maria Martha ; Battastini, Ana Maria Oliveira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-fa9ab39c8f13fb1c0c08ff85a462a25a4e9c146c4afd450a37852566a51771d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acids</topic><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Antineoplastic drugs</topic><topic>Antitumor agents</topic><topic>Behavior, Animal</topic><topic>Bladder</topic><topic>Cat's Claw - chemistry</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - adverse effects</topic><topic>Cystitis</topic><topic>Cystitis - chemically induced</topic><topic>Cystitis - complications</topic><topic>Cystitis - drug therapy</topic><topic>Cystitis - physiopathology</topic><topic>Cytochrome P-450</topic><topic>Disease</topic><topic>Drug development</topic><topic>Drugs</topic><topic>Edema</topic><topic>Glycosides</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Glycosides - therapeutic use</topic><topic>Health aspects</topic><topic>Hemorrhage</topic><topic>Hemorrhage - chemically induced</topic><topic>Hemorrhage - complications</topic><topic>Hemorrhage - drug therapy</topic><topic>Hemorrhage - physiopathology</topic><topic>Hemorrhagic cystitis</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Interleukin-1beta - metabolism</topic><topic>Lesions</topic><topic>Leukocyte migration</topic><topic>Leukocytes (neutrophilic)</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Mice</topic><topic>Nociception - drug effects</topic><topic>Pain</topic><topic>Peroxidase - metabolism</topic><topic>Protective Agents - pharmacology</topic><topic>Protective Agents - therapeutic use</topic><topic>Purine receptors</topic><topic>Receptors</topic><topic>Receptors, Purinergic P2X7 - metabolism</topic><topic>Rodents</topic><topic>Sodium</topic><topic>Sodium 2-mercaptoethanesulfonate</topic><topic>Stability</topic><topic>Studies</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><topic>Triterpenes - therapeutic use</topic><topic>Uncaria tomentosa</topic><topic>Urinary bladder</topic><topic>Urinary Bladder - drug effects</topic><topic>Urinary tract</topic><topic>Viscera - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dietrich, Fabrícia</creatorcontrib><creatorcontrib>Pietrobon Martins, Jerônimo</creatorcontrib><creatorcontrib>Kaiser, Samuel</creatorcontrib><creatorcontrib>Madeira Silva, Rodrigo Braccini</creatorcontrib><creatorcontrib>Rockenbach, Liliana</creatorcontrib><creatorcontrib>Albano Edelweiss, Maria Isabel</creatorcontrib><creatorcontrib>Ortega, George González</creatorcontrib><creatorcontrib>Morrone, Fernanda Bueno</creatorcontrib><creatorcontrib>Campos, Maria Martha</creatorcontrib><creatorcontrib>Battastini, Ana Maria Oliveira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dietrich, Fabrícia</au><au>Pietrobon Martins, Jerônimo</au><au>Kaiser, Samuel</au><au>Madeira Silva, Rodrigo Braccini</au><au>Rockenbach, Liliana</au><au>Albano Edelweiss, Maria Isabel</au><au>Ortega, George González</au><au>Morrone, Fernanda Bueno</au><au>Campos, Maria Martha</au><au>Battastini, Ana Maria Oliveira</au><au>Singh, Udai P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Quinovic Acid Glycosides Purified Fraction from Uncaria tomentosa Protects against Hemorrhagic Cystitis Induced by Cyclophosphamide in Mice</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-08</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0131882</spage><epage>e0131882</epage><pages>e0131882-e0131882</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been used to prevent the occurrence of HE, although this compound is not effective in established lesions. It has been demonstrated that the purinergic system is involved in several pathophysiological events. Among purinergic receptors, P2X7 deserves attention because it is involved in HE induced by CYP and, therefore, can be considered a therapeutic target. The objective of this study was to investigate the potential therapeutic effect of the quinovic acid glycosides purified fraction (QAPF) from U. tomentosa in the mouse model of CYP-induced HE. Pretreatment with QAPF not only had a protective effect on HE-induced urothelial damage (edema, hemorrhage and bladder wet weight) but was also able to control visceral pain, decrease IL-1β levels and down-regulates P2X7 receptors, most likely by inhibit the neutrophils migration to the bladder. This research clearly demonstrates the promising anti-inflammatory properties of QAPF, supporting its use as complementary therapy. QAPF represents a promising therapeutic option for this pathological condition.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26154141</pmid><doi>10.1371/journal.pone.0131882</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-07, Vol.10 (7), p.e0131882-e0131882 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1694958100 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acids Animals Anti-inflammatory agents Antineoplastic drugs Antitumor agents Behavior, Animal Bladder Cat's Claw - chemistry Cyclophosphamide Cyclophosphamide - adverse effects Cystitis Cystitis - chemically induced Cystitis - complications Cystitis - drug therapy Cystitis - physiopathology Cytochrome P-450 Disease Drug development Drugs Edema Glycosides Glycosides - isolation & purification Glycosides - pharmacology Glycosides - therapeutic use Health aspects Hemorrhage Hemorrhage - chemically induced Hemorrhage - complications Hemorrhage - drug therapy Hemorrhage - physiopathology Hemorrhagic cystitis IL-1β Inflammation Interleukin-1beta - metabolism Lesions Leukocyte migration Leukocytes (neutrophilic) Male Medical treatment Mice Nociception - drug effects Pain Peroxidase - metabolism Protective Agents - pharmacology Protective Agents - therapeutic use Purine receptors Receptors Receptors, Purinergic P2X7 - metabolism Rodents Sodium Sodium 2-mercaptoethanesulfonate Stability Studies Triterpenes - isolation & purification Triterpenes - pharmacology Triterpenes - therapeutic use Uncaria tomentosa Urinary bladder Urinary Bladder - drug effects Urinary tract Viscera - drug effects |
| title | The Quinovic Acid Glycosides Purified Fraction from Uncaria tomentosa Protects against Hemorrhagic Cystitis Induced by Cyclophosphamide in Mice |
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