The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells

Koelreuteria henryi Dummer, an endemic plant of Taiwan, has been used as a folk medicine for the treatment of hepatitis, enteritis, cough, pharyngitis, allergy, hypertension, hyperlipidemia, and cancer. Austrobailignan-1, a natural lignan derivative isolated from Koelreuteria henryi Dummer, has anti...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132052-e0132052
Hauptverfasser:	Wu, Chun-Chi, Huang, Keh-Feng, Yang, Tsung-Ying, Li, Ya-Ling, Wen, Chi-Luan, Hsu, Shih-Lan, Chen, Tzu-Hsiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Allergies Analysis Anticancer properties Apoptosis Automated teller machines Bax protein Bcl-2 protein Biochemistry Cancer Cancer cells Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Care and treatment Caspase Caspase-2 Cell cycle Cell death Cell Death - drug effects Cell Line, Tumor CHK1 protein CHK2 protein Cough Cyclin-dependent kinase inhibitor p21 Cyclin-dependent kinase inhibitor p27 Cytochrome Cytochrome c Cytotoxicity Damage Data processing Deoxyribonucleic acid DNA DNA damage DNA topoisomerase DNA Topoisomerases, Type I - metabolism Enteritis Flow cytometry G2 Phase Cell Cycle Checkpoints - drug effects Hepatitis Herbal medicine Humans Hyperlipidemia Hypersensitivity Hypertension Inhibitors Kinases Koelreuteria Lignans - chemistry Lignans - pharmacology Lung cancer Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology M Phase Cell Cycle Checkpoints - drug effects Medical research Medicinal plants Medicine Non-small cell lung cancer p53 Protein Pharmaceuticals Plants, Medicinal - chemistry Proteins Signal transduction Signaling Small cell lung cancer Topoisomerase I Inhibitors - chemistry Topoisomerase I Inhibitors - pharmacology Tumor cell lines Tumor proteins Tumor Suppressor Protein p53 - metabolism
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