A Potent Inhibitor of Phosphoinositide 3-Kinase (PI3K) and Mitogen Activated Protein (MAP) Kinase Signalling, Quercetin (3, 3', 4', 5, 7-Pentahydroxyflavone) Promotes Cell Death in Ultraviolet (UV)-B-Irradiated B16F10 Melanoma Cells

Ultraviolet (UV) radiation-induced skin damage contributes strongly to the formation of melanoma, a highly lethal form of skin cancer. Quercetin (Qu), the most widely consumed dietary bioflavonoid and well known inhibitor of phosphoinositide 3-kinase (PI3K) and mitogen activated protein (MAP) kinase...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0131253
Hauptverfasser:	Rafiq, Rather A, Quadri, Afnan, Nazir, Lone A, Peerzada, Kaiser, Ganai, Bashir A, Tasduq, Sheikh A
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adenosine diphosphate AKT protein Animals Apoptosis Apoptosis - drug effects Apoptosis Inducing Factor - metabolism Apoptosis-inducing factor BAX protein Bcl-2 protein BIM protein Calcium Calcium - metabolism Calcium homeostasis Caspase Caspases - metabolism Cell death Cell Death - drug effects Cell Line Cell Line, Tumor Cell Survival - drug effects Cleavage Deoxyribonucleic acid Depolarization Diet DNA Enzyme inhibitors Extracellular signal-regulated kinase G1 Phase - drug effects Homeostasis Humans Inhibitors Kinases Lymphocytes B Melanoma Melanoma - metabolism Membrane potential Membrane Potential, Mitochondrial - drug effects Mice Mitochondria Mitogen-Activated Protein Kinases - antagonists & inhibitors NF-kappa B - metabolism NF-κB protein Oxidizing agents Oxygen Phosphatidylinositol 3-Kinases - antagonists & inhibitors Poly(ADP-ribose) polymerase Quercetin - pharmacology Radiation Radiation damage Reactive oxygen species Reactive Oxygen Species - metabolism Ribose Signal transduction Signal Transduction - drug effects Signaling Skin cancer Skin diseases Translocation Ultraviolet radiation Ultraviolet Rays
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