Protective Effects of N-Acetyl Cysteine against Diesel Exhaust Particles-Induced Intracellular ROS Generates Pro-Inflammatory Cytokines to Mediate the Vascular Permeability of Capillary-Like Endothelial Tubes

Exposure to diesel exhaust particles (DEP) is associated with pulmonary and cardiovascular diseases. Previous studies using in vitro endothelial tubes as a simplified model of capillaries have found that DEP-induced ROS increase vascular permeability with rearrangement or internalization of adherens...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0131911
Hauptverfasser:	Tseng, Chia-Yi, Chang, Jing-Fen, Wang, Jhih-Syuan, Chang, Yu-Jung, Gordon, Marion K, Chao, Ming-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Adherens Junctions - drug effects Adherens Junctions - metabolism Angiogenesis Antigens, CD - metabolism Cadherin Cadherins Cadherins - metabolism Capillaries Capillaries - drug effects Capillary Permeability - drug effects Capillary tubes Cardiovascular diseases Cell growth Cells, Cultured Cysteine - pharmacology Cytokines Cytokines - metabolism Diesel Diesel engines Endothelial cells Endothelium Exposure Glutathione Heart diseases Heme Oxygenase-1 - metabolism Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Inflammation Inflammation - chemically induced Inflammation - metabolism Inflammatory response Interleukin 6 Interleukin-6 - metabolism Internalization Intracellular Lung diseases Membrane permeability Nanotechnology Oxidative stress Oxidative Stress - drug effects Particulate Matter - adverse effects Particulates Permeability Protective Agents - pharmacology Reactive Oxygen Species - metabolism Rodents Science Supplementation Supplements Toxicology Tubes Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Umbilical vein Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vehicle Emissions - toxicity
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