Polarized Trafficking of AQP2 Revealed in Three Dimensional Epithelial Culture

In renal collecting duct (CD) principal cells (PCs), vasopressin (VP) acts through its receptor, V2R, to increase intracellular cAMP leading to phosphorylation and apical membrane accumulation of the water channel aquaporin 2 (AQP2). The trafficking and function of basolaterally located AQP2 is, how...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0131719-e0131719
Hauptverfasser:	Rice, William L, Li, Wei, Mamuya, Fahmy, McKee, Mary, Păunescu, Teodor G, Lu, Hua A Jenny
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Antibodies Aquaporin 2 Aquaporin 2 - metabolism Aquaporins Biology Cell adhesion & migration Cell culture Cells, Cultured Collecting duct Cyclic AMP Cyclodextrins Cysts Data processing Dogs Endocytosis Epithelial Cells - metabolism Extracellular matrix Forskolin Kidneys Kinases Localization Luminance distribution Madin Darby Canine Kidney Cells Medical schools Medicine Methyl-β-Cyclodextrin Morphogenesis Nephrology Phosphorylation Preservation Protein Transport Regulation Regulatory mechanisms (biology) Rodents Sodium Three dimensional models Translocation Vasopressin Vasopressin V2 receptors
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