Structural Rigidity and Protein Thermostability in Variants of Lipase A from Bacillus subtilis

Understanding the origin of thermostability is of fundamental importance in protein biochemistry. Opposing views on increased or decreased structural rigidity of the folded state have been put forward in this context. They have been related to differences in the temporal resolution of experiments an...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0130289-e0130289
Hauptverfasser:	Rathi, Prakash Chandra, Jaeger, Karl-Erich, Gohlke, Holger
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Atomic properties Bacillus subtilis Bacillus subtilis - genetics Bacterial Proteins - genetics Biochemistry Enzyme Stability - genetics Enzymes Equilibrium Genetic Variation - genetics Homology Hot Temperature Lipase Lipase - genetics Molecular biology Molecular Dynamics Simulation Mutagenesis Mutants Mutation Mutation - genetics Network analysis Network topologies Phase transitions Proteins Rigidity Structural stability Studies Temporal resolution Thermal stability Thermodynamics
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