3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population
MicroRNAs play an important role in cancer initiation and development. The aim of this study was to investigate whether polymorphisms in miRNA machinery genes are associated with the development of colorectal cancer (CRC). RAN rs14035 CT heterozygotes and T allele carriers (CT + TT) genotypes had lo...
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| description | MicroRNAs play an important role in cancer initiation and development. The aim of this study was to investigate whether polymorphisms in miRNA machinery genes are associated with the development of colorectal cancer (CRC). RAN rs14035 CT heterozygotes and T allele carriers (CT + TT) genotypes had lower risk of CRC, while the DICER1 rs3742330, DROSHA rs10719, and XPO5 rs11077 polymorphisms were not associated with CRC in the full study sample. Specifically, male RAN rs14035 CT heterozygotes and XPO5 rs11077 AA genotype (CT/AA) carriers experienced reduced CRC susceptibility (both colon and rectal). Subgroup analysis demonstrated that the combined RAN rs14035 CT + TT genotype was associated with rectal cancer, but not colon cancer. In addition, the DICER1 rs3742330 AG genotype was associated with a significantly increased risk of colon cancer. Stratified analysis revealed the RAN rs14035 combined CT+TT genotype was associated with decreased CRC risk in male patients without diabetes mellitus (DM) and in patients with rectal cancer. In addition, we found the RAN rs14035 CC genotype was related to a decreased risk of CRC with respect to tumor size and metabolism of homocysteine and folate. Furthermore, patients diagnosed with hypertension or DM who carried the DROSHA rs10719 CC genotype showed increased CRC risk, while the XPO5 rs11077 AC+CC genotype led to increased CRC risk in patients with hypertension only. Our results indicate variations in RAN rs14035, DICER1 rs3742330, XPO5 rs11077, and DROSHA rs10719 of Korean patients are significantly associated with their risk of CRC. |
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The aim of this study was to investigate whether polymorphisms in miRNA machinery genes are associated with the development of colorectal cancer (CRC). RAN rs14035 CT heterozygotes and T allele carriers (CT + TT) genotypes had lower risk of CRC, while the DICER1 rs3742330, DROSHA rs10719, and XPO5 rs11077 polymorphisms were not associated with CRC in the full study sample. Specifically, male RAN rs14035 CT heterozygotes and XPO5 rs11077 AA genotype (CT/AA) carriers experienced reduced CRC susceptibility (both colon and rectal). Subgroup analysis demonstrated that the combined RAN rs14035 CT + TT genotype was associated with rectal cancer, but not colon cancer. In addition, the DICER1 rs3742330 AG genotype was associated with a significantly increased risk of colon cancer. Stratified analysis revealed the RAN rs14035 combined CT+TT genotype was associated with decreased CRC risk in male patients without diabetes mellitus (DM) and in patients with rectal cancer. In addition, we found the RAN rs14035 CC genotype was related to a decreased risk of CRC with respect to tumor size and metabolism of homocysteine and folate. Furthermore, patients diagnosed with hypertension or DM who carried the DROSHA rs10719 CC genotype showed increased CRC risk, while the XPO5 rs11077 AC+CC genotype led to increased CRC risk in patients with hypertension only. Our results indicate variations in RAN rs14035, DICER1 rs3742330, XPO5 rs11077, and DROSHA rs10719 of Korean patients are significantly associated with their risk of CRC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0131125</identifier><identifier>PMID: 26147304</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>3' Untranslated Regions ; Adenocarcinoma - genetics ; Adult ; Aged ; Binding sites ; Biomarkers ; Cancer ; Carriers ; Colon ; Colon cancer ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - genetics ; DEAD-box RNA Helicases - genetics ; Deoxyribonucleic acid ; Diabetes ; Diabetes mellitus ; DNA ; Female ; Folic acid ; Folic Acid - metabolism ; Gene expression ; Gene Frequency ; Genes ; Genetic Predisposition to Disease ; Genotype ; Genotypes ; Health risk assessment ; Health risks ; Heterozygotes ; Homocysteine ; Homocysteine - metabolism ; Humans ; Hypertension ; Insulin resistance ; Internal medicine ; Karyopherins - genetics ; Life sciences ; Male ; Medical prognosis ; Medical screening ; Metabolic syndrome ; Metabolism ; MicroRNAs ; MicroRNAs - metabolism ; Middle Aged ; miRNA ; Patients ; Polymorphism, Single Nucleotide ; Population ; ran GTP-Binding Protein - genetics ; Rectum ; Republic of Korea - epidemiology ; Ribonuclease III - genetics ; Risk ; RNA, Neoplasm - metabolism ; Studies ; Tumor Burden ; Tumors ; Vitamin B</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0131125-e0131125</ispartof><rights>2015 Cho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Cho et al 2015 Cho et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-bc98a5049f9ccbf2e837d1d9c5e072b69db488249e3c98dd058da9fb2204f7753</citedby><cites>FETCH-LOGICAL-c526t-bc98a5049f9ccbf2e837d1d9c5e072b69db488249e3c98dd058da9fb2204f7753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492935/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492935/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26147304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zhao, Jian-Jun</contributor><creatorcontrib>Cho, Sung Hwan</creatorcontrib><creatorcontrib>Ko, Jung Jae</creatorcontrib><creatorcontrib>Kim, Jung Oh</creatorcontrib><creatorcontrib>Jeon, Young Joo</creatorcontrib><creatorcontrib>Yoo, Jung Ki</creatorcontrib><creatorcontrib>Oh, Jisu</creatorcontrib><creatorcontrib>Oh, Doyeun</creatorcontrib><creatorcontrib>Kim, Jong Woo</creatorcontrib><creatorcontrib>Kim, Nam Keun</creatorcontrib><title>3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>MicroRNAs play an important role in cancer initiation and development. The aim of this study was to investigate whether polymorphisms in miRNA machinery genes are associated with the development of colorectal cancer (CRC). RAN rs14035 CT heterozygotes and T allele carriers (CT + TT) genotypes had lower risk of CRC, while the DICER1 rs3742330, DROSHA rs10719, and XPO5 rs11077 polymorphisms were not associated with CRC in the full study sample. Specifically, male RAN rs14035 CT heterozygotes and XPO5 rs11077 AA genotype (CT/AA) carriers experienced reduced CRC susceptibility (both colon and rectal). Subgroup analysis demonstrated that the combined RAN rs14035 CT + TT genotype was associated with rectal cancer, but not colon cancer. In addition, the DICER1 rs3742330 AG genotype was associated with a significantly increased risk of colon cancer. Stratified analysis revealed the RAN rs14035 combined CT+TT genotype was associated with decreased CRC risk in male patients without diabetes mellitus (DM) and in patients with rectal cancer. In addition, we found the RAN rs14035 CC genotype was related to a decreased risk of CRC with respect to tumor size and metabolism of homocysteine and folate. Furthermore, patients diagnosed with hypertension or DM who carried the DROSHA rs10719 CC genotype showed increased CRC risk, while the XPO5 rs11077 AC+CC genotype led to increased CRC risk in patients with hypertension only. Our results indicate variations in RAN rs14035, DICER1 rs3742330, XPO5 rs11077, and DROSHA rs10719 of Korean patients are significantly associated with their risk of CRC.</description><subject>3' Untranslated Regions</subject><subject>Adenocarcinoma - genetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Binding sites</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Carriers</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - genetics</subject><subject>DEAD-box RNA Helicases - genetics</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>DNA</subject><subject>Female</subject><subject>Folic acid</subject><subject>Folic Acid - metabolism</subject><subject>Gene expression</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heterozygotes</subject><subject>Homocysteine</subject><subject>Homocysteine - metabolism</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Insulin resistance</subject><subject>Internal medicine</subject><subject>Karyopherins - genetics</subject><subject>Life sciences</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical screening</subject><subject>Metabolic syndrome</subject><subject>Metabolism</subject><subject>MicroRNAs</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Patients</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>ran GTP-Binding Protein - genetics</subject><subject>Rectum</subject><subject>Republic of Korea - epidemiology</subject><subject>Ribonuclease III - genetics</subject><subject>Risk</subject><subject>RNA, Neoplasm - metabolism</subject><subject>Studies</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>Vitamin B</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUttu0zAYjhCIHeANEFjiAi7a4lOc-AYp6sZWsa1T2CTuLMd2VneuXex0qI_BG5Ou3bQhrmz5_06_9WXZOwRHiBToyzysopdutAzejCAiCOH8RbaPOMFDhiF5-eS-lx2kNIcwJyVjr7M9zBAtCKT72R_yaXh9VYPL4NaLEJczmxYJWA-6mQHntr6owLlUM-tNXIMT400CR_X0x2k1AEeT8XGNBqCuLgZAeg1-Xk5zUEUDqpSCsrIzGvy23QyMgwvRqE46MJZemQhqm243LhJ87yfS9_7LlZOdDf5N9qqVLpm3u_Mwu_52fDU-HZ5NTybj6myocsy6YaN4KXNIecuValpsSlJopLnKDSxww7huaFliyg3pkVrDvNSStw3GkLZFkZPD7MNWd-lCErvfTAIxTnNUQAp7xGSL0EHOxTLahYxrEaQV9w8h3ggZO6ucEdoQJHXRSsYZ5VTzNie0KSRRsmCGs17r685t1SyMVsZ3Ubpnos8n3s7ETbgTlHLMySbu551ADL9WJnViYZMyzklvwmqbmzNc3nt9_Af6_-3oFqViSCma9jEMgmLTsAeW2DRM7BrW094_XeSR9FAp8hcxzMy8</recordid><startdate>20150706</startdate><enddate>20150706</enddate><creator>Cho, Sung Hwan</creator><creator>Ko, Jung Jae</creator><creator>Kim, Jung Oh</creator><creator>Jeon, Young Joo</creator><creator>Yoo, Jung Ki</creator><creator>Oh, Jisu</creator><creator>Oh, Doyeun</creator><creator>Kim, Jong Woo</creator><creator>Kim, Nam Keun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150706</creationdate><title>3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population</title><author>Cho, Sung Hwan ; Ko, Jung Jae ; Kim, Jung Oh ; Jeon, Young Joo ; Yoo, Jung Ki ; Oh, Jisu ; Oh, Doyeun ; Kim, Jong Woo ; Kim, Nam Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-bc98a5049f9ccbf2e837d1d9c5e072b69db488249e3c98dd058da9fb2204f7753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>3' Untranslated Regions</topic><topic>Adenocarcinoma - genetics</topic><topic>Adult</topic><topic>Aged</topic><topic>Binding sites</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Carriers</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - genetics</topic><topic>DEAD-box RNA Helicases - genetics</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>DNA</topic><topic>Female</topic><topic>Folic acid</topic><topic>Folic Acid - metabolism</topic><topic>Gene expression</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Heterozygotes</topic><topic>Homocysteine</topic><topic>Homocysteine - metabolism</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Insulin resistance</topic><topic>Internal medicine</topic><topic>Karyopherins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Sung Hwan</au><au>Ko, Jung Jae</au><au>Kim, Jung Oh</au><au>Jeon, Young Joo</au><au>Yoo, Jung Ki</au><au>Oh, Jisu</au><au>Oh, Doyeun</au><au>Kim, Jong Woo</au><au>Kim, Nam Keun</au><au>Zhao, Jian-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-06</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0131125</spage><epage>e0131125</epage><pages>e0131125-e0131125</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>MicroRNAs play an important role in cancer initiation and development. The aim of this study was to investigate whether polymorphisms in miRNA machinery genes are associated with the development of colorectal cancer (CRC). RAN rs14035 CT heterozygotes and T allele carriers (CT + TT) genotypes had lower risk of CRC, while the DICER1 rs3742330, DROSHA rs10719, and XPO5 rs11077 polymorphisms were not associated with CRC in the full study sample. Specifically, male RAN rs14035 CT heterozygotes and XPO5 rs11077 AA genotype (CT/AA) carriers experienced reduced CRC susceptibility (both colon and rectal). Subgroup analysis demonstrated that the combined RAN rs14035 CT + TT genotype was associated with rectal cancer, but not colon cancer. In addition, the DICER1 rs3742330 AG genotype was associated with a significantly increased risk of colon cancer. Stratified analysis revealed the RAN rs14035 combined CT+TT genotype was associated with decreased CRC risk in male patients without diabetes mellitus (DM) and in patients with rectal cancer. In addition, we found the RAN rs14035 CC genotype was related to a decreased risk of CRC with respect to tumor size and metabolism of homocysteine and folate. Furthermore, patients diagnosed with hypertension or DM who carried the DROSHA rs10719 CC genotype showed increased CRC risk, while the XPO5 rs11077 AC+CC genotype led to increased CRC risk in patients with hypertension only. Our results indicate variations in RAN rs14035, DICER1 rs3742330, XPO5 rs11077, and DROSHA rs10719 of Korean patients are significantly associated with their risk of CRC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26147304</pmid><doi>10.1371/journal.pone.0131125</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1694517040 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 3' Untranslated Regions Adenocarcinoma - genetics Adult Aged Binding sites Biomarkers Cancer Carriers Colon Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics DEAD-box RNA Helicases - genetics Deoxyribonucleic acid Diabetes Diabetes mellitus DNA Female Folic acid Folic Acid - metabolism Gene expression Gene Frequency Genes Genetic Predisposition to Disease Genotype Genotypes Health risk assessment Health risks Heterozygotes Homocysteine Homocysteine - metabolism Humans Hypertension Insulin resistance Internal medicine Karyopherins - genetics Life sciences Male Medical prognosis Medical screening Metabolic syndrome Metabolism MicroRNAs MicroRNAs - metabolism Middle Aged miRNA Patients Polymorphism, Single Nucleotide Population ran GTP-Binding Protein - genetics Rectum Republic of Korea - epidemiology Ribonuclease III - genetics Risk RNA, Neoplasm - metabolism Studies Tumor Burden Tumors Vitamin B |
| title | 3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T00%3A02%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=3'-UTR%20Polymorphisms%20in%20the%20MiRNA%20Machinery%20Genes%20DROSHA,%20DICER1,%20RAN,%20and%20XPO5%20Are%20Associated%20with%20Colorectal%20Cancer%20Risk%20in%20a%20Korean%20Population&rft.jtitle=PloS%20one&rft.au=Cho,%20Sung%20Hwan&rft.date=2015-07-06&rft.volume=10&rft.issue=7&rft.spage=e0131125&rft.epage=e0131125&rft.pages=e0131125-e0131125&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0131125&rft_dat=%3Cproquest_plos_%3E3736055411%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1694517040&rft_id=info:pmid/26147304&rft_doaj_id=oai_doaj_org_article_de31ad7fa696494d9f534b7a3ca76e96&rfr_iscdi=true |