Identification of an Immunogenic Mimic of a Conserved Epitope on the Plasmodium falciparum Blood Stage Antigen AMA1 Using Virus-Like Particle (VLP) Peptide Display

We have developed a peptide display platform based on VLPs of the RNA bacteriophage MS2 that combines the high immunogenicity of VLP display with affinity selection capabilities. Random peptides can be displayed on the VLP surface by genetically inserting sequences into a surface-exposed loop of the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132560-e0132560
Hauptverfasser:	Crossey, Erin, Frietze, Kathryn, Narum, David L, Peabody, David S, Chackerian, Bryce
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - immunology Antibodies, Protozoan - immunology Antibody Affinity Antigen-Antibody Reactions Antigenic determinants Antigens Antigens, Protozoan - chemistry Antigens, Protozoan - immunology Antigens, Surface - chemistry Antigens, Surface - immunology Blood Chromatography, Gel Coat protein Cross Reactions Dimerization Enzyme-Linked Immunosorbent Assay Epitopes Epitopes - chemistry Epitopes - immunology Erythrocytes Genomes Immunogenicity Immunoglobulins Levivirus Localization Malaria Malaria Vaccines - immunology Membrane Proteins - chemistry Membrane Proteins - immunology Mice Mice, Inbred BALB C Models, Molecular Molecular Sequence Data Monoclonal antibodies Mutagenesis, Site-Directed Parasites Peptide libraries Peptide Library Peptides Peptides - chemistry Peptides - immunology Plasmids Plasmodium Plasmodium falciparum Plasmodium falciparum - immunology Protein Conformation Proteins Protozoan Proteins - chemistry Protozoan Proteins - immunology Ribonucleic acid RNA RNA phages Sequence Analysis, Protein Vaccines Vaccines, Virus-Like Particle - immunology Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!