Ubiquitous promoter-localization of essential virulence regulators in Francisella tularensis

Francisella tularensis is a Gram-negative bacterium whose ability to replicate within macrophages and cause disease is strictly dependent upon the coordinate activities of three transcription regulators called MglA, SspA, and PigR. MglA and SspA form a complex that associates with RNA polymerase (RN...

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Veröffentlicht in:	PLoS pathogens 2015-04, Vol.11 (4), p.e1004793-e1004793
Hauptverfasser:	Ramsey, Kathryn M, Osborne, Melisa L, Vvedenskaya, Irina O, Su, Cathy, Nickels, Bryce E, Dove, Simon L
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Chromatin Immunoprecipitation Deoxyribonucleic acid DNA Electroporation Experiments Francisella tularensis Francisella tularensis - genetics Francisella tularensis - pathogenicity Gene expression Gene Expression Regulation, Bacterial - genetics Genes, Bacterial Genetic aspects Health aspects High-Throughput Nucleotide Sequencing Identification and classification Immunoblotting Promoter Regions, Genetic - genetics Promoters (Genetics) Proteins RNA polymerase Transcription factors Transcription Factors - genetics Virulence (Microbiology) Virulence - genetics
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