Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich's Ascites Tumor in Mice

Dietary energy restriction (DER) has been well established as a potent anticancer strategy. Non-adoption of restricted diet for an extended period has limited its practical implementation in humans with a compelling need to develop agents that mimic effects similar to DER, without reduction in actua...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132089-e0132089
Hauptverfasser:	Singh, Saurabh, Pandey, Sanjay, Bhatt, Anant Narayan, Chaudhary, Richa, Bhuria, Vikas, Kalra, Namita, Soni, Ravi, Roy, Bal Gangadhar, Saluja, Daman, Dwarakanath, Bilikere S
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Aging AKT protein Analysis Angiogenesis Animal growth Animals Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - blood Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Ascites Biomedical research Biotechnology Blood glucose Blood Glucose - analysis Brain cancer Bromodeoxyuridine Caloric Restriction Cancer therapies Carcinoma, Ehrlich Tumor - blood supply Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Ehrlich Tumor - immunology CD4 antigen CD4-CD8 Ratio CD8 antigen Cell cycle Cell Division - drug effects Cytotoxicity Deoxyglucose - administration & dosage Deoxyglucose - blood Deoxyglucose - pharmacology Deoxyglucose - therapeutic use Diet Dietary intake Dietary restrictions Drinking water Drug Screening Assays, Antitumor Energy Female Glucose Glycolysis Glycolysis - drug effects Growth Hypoxia Immunity Immunoregulation Implantation Inhibitors Insulin Insulin - blood Insulin-like growth factors Ionizing radiation Kinases Laboratories Lymphocytes Lymphocytes T Matrix Metalloproteinase 9 - analysis Metabolic pathways Metabolism Mice Mimicry Neoplasm Proteins - physiology Neovascularization, Pathologic - drug therapy Nuclear medicine Physiological aspects Premedication Proliferating cell nuclear antigen Prostate Random Allocation Rodents Signal transduction Signal Transduction - drug effects T cells T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Tumor Burden - drug effects Tumor cells Tumorigenesis Tumors
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