IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice
Interleukin-1 receptor antagonist (IL-1Ra) is the primary therapy against autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and associated organ injury. However, patients receiving IL-1Ra might be at increased risk of acquiring serious infections. To study whether IL-...
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creator | Ali, Abukar Na, Manli Svensson, Mattias N D Magnusson, Malin Welin, Amanda Schwarze, Jan-Christoph Mohammad, Majd Josefsson, Elisabet Pullerits, Rille Jin, Tao |
description | Interleukin-1 receptor antagonist (IL-1Ra) is the primary therapy against autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and associated organ injury. However, patients receiving IL-1Ra might be at increased risk of acquiring serious infections.
To study whether IL-1Ra treatment deteriorates Staphylococcus aureus (S. aureus) septic arthritis and sepsis in mice.
NMRI mice were treated with anakinra (IL-1Ra) daily for 7 days before intravenous inoculation with S. aureus strain Newman in both arthritogenic and lethal doses. The clinical course of septic arthritis, histopathological and radiological changes of the joints, as well as the mortality were compared between IL-1Ra treated and control groups.
IL-1Ra treated mice developed more frequent and severe clinical septic arthritis. Also, the frequency of polyarthritis was significantly higher in the mice receiving IL-1Ra therapy. In line with the data from clinical arthritis, both histological and radiological signs of septic arthritis were more pronounced in IL-1Ra treated group compared to controls. Importantly, the mortality of IL-1Ra treated mice was significantly higher than PBS treated controls.
IL-1Ra treatment significantly aggravated S. aureus induced septic arthritis and increased the mortality in these mice. |
doi_str_mv | 10.1371/journal.pone.0131645 |
format | Article |
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To study whether IL-1Ra treatment deteriorates Staphylococcus aureus (S. aureus) septic arthritis and sepsis in mice.
NMRI mice were treated with anakinra (IL-1Ra) daily for 7 days before intravenous inoculation with S. aureus strain Newman in both arthritogenic and lethal doses. The clinical course of septic arthritis, histopathological and radiological changes of the joints, as well as the mortality were compared between IL-1Ra treated and control groups.
IL-1Ra treated mice developed more frequent and severe clinical septic arthritis. Also, the frequency of polyarthritis was significantly higher in the mice receiving IL-1Ra therapy. In line with the data from clinical arthritis, both histological and radiological signs of septic arthritis were more pronounced in IL-1Ra treated group compared to controls. Importantly, the mortality of IL-1Ra treated mice was significantly higher than PBS treated controls.
IL-1Ra treatment significantly aggravated S. aureus induced septic arthritis and increased the mortality in these mice.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0131645</identifier><identifier>PMID: 26135738</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Antibiotics ; Arthritis ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - microbiology ; Arthritis, Infectious - drug therapy ; Arthritis, Infectious - microbiology ; B cells ; Comparative analysis ; Cytokines ; Cytokines - metabolism ; Disease ; Disease Models, Animal ; Drug dosages ; Drug therapy ; Experiments ; Female ; Health aspects ; Health risks ; Immune system ; Immunologi inom det medicinska området ; Immunology in the medical area ; Infection ; Infectious arthritis ; Inflammation ; Inflammation - drug therapy ; Inflammation - metabolism ; Injury prevention ; Inoculation ; Interleukin 1 ; Interleukin 1 receptor antagonist ; Interleukin 1 Receptor Antagonist Protein - therapeutic use ; Intravenous administration ; Joint diseases ; Joints - pathology ; Kidney - pathology ; Laboratories ; Macrophages, Peritoneal - metabolism ; Medical research ; Medicine ; Mice ; Mortality ; Neutrophils ; Pneumonia ; Polyarthritis ; Rheumatology ; Rodents ; Sepsis ; Sepsis - drug therapy ; Sepsis - microbiology ; Staphylococcal infections ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Staphylococcus ; Staphylococcus aureus ; Staphylococcus infections ; Therapy ; TNF inhibitors ; X-Ray Microtomography</subject><ispartof>PloS one, 2015-07, Vol.10 (7), p.e0131645-e0131645</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Ali et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Ali et al 2015 Ali et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c796t-c9fd76a4b309fefc09b430879c5221a654ebb4749ae25da1efe1fa336cfa0a2f3</citedby><cites>FETCH-LOGICAL-c796t-c9fd76a4b309fefc09b430879c5221a654ebb4749ae25da1efe1fa336cfa0a2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489902/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489902/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26135738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/219419$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Gao, Hongwei</contributor><creatorcontrib>Ali, Abukar</creatorcontrib><creatorcontrib>Na, Manli</creatorcontrib><creatorcontrib>Svensson, Mattias N D</creatorcontrib><creatorcontrib>Magnusson, Malin</creatorcontrib><creatorcontrib>Welin, Amanda</creatorcontrib><creatorcontrib>Schwarze, Jan-Christoph</creatorcontrib><creatorcontrib>Mohammad, Majd</creatorcontrib><creatorcontrib>Josefsson, Elisabet</creatorcontrib><creatorcontrib>Pullerits, Rille</creatorcontrib><creatorcontrib>Jin, Tao</creatorcontrib><title>IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Interleukin-1 receptor antagonist (IL-1Ra) is the primary therapy against autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and associated organ injury. However, patients receiving IL-1Ra might be at increased risk of acquiring serious infections.
To study whether IL-1Ra treatment deteriorates Staphylococcus aureus (S. aureus) septic arthritis and sepsis in mice.
NMRI mice were treated with anakinra (IL-1Ra) daily for 7 days before intravenous inoculation with S. aureus strain Newman in both arthritogenic and lethal doses. The clinical course of septic arthritis, histopathological and radiological changes of the joints, as well as the mortality were compared between IL-1Ra treated and control groups.
IL-1Ra treated mice developed more frequent and severe clinical septic arthritis. Also, the frequency of polyarthritis was significantly higher in the mice receiving IL-1Ra therapy. In line with the data from clinical arthritis, both histological and radiological signs of septic arthritis were more pronounced in IL-1Ra treated group compared to controls. Importantly, the mortality of IL-1Ra treated mice was significantly higher than PBS treated controls.
IL-1Ra treatment significantly aggravated S. aureus induced septic arthritis and increased the mortality in these mice.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Arthritis</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - microbiology</subject><subject>Arthritis, Infectious - drug therapy</subject><subject>Arthritis, Infectious - microbiology</subject><subject>B cells</subject><subject>Comparative analysis</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Disease</subject><subject>Disease Models, Animal</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Experiments</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Immune system</subject><subject>Immunologi inom det medicinska området</subject><subject>Immunology in the medical area</subject><subject>Infection</subject><subject>Infectious arthritis</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Injury prevention</subject><subject>Inoculation</subject><subject>Interleukin 1</subject><subject>Interleukin 1 receptor antagonist</subject><subject>Interleukin 1 Receptor Antagonist Protein - therapeutic use</subject><subject>Intravenous administration</subject><subject>Joint diseases</subject><subject>Joints - pathology</subject><subject>Kidney - pathology</subject><subject>Laboratories</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Mice</subject><subject>Mortality</subject><subject>Neutrophils</subject><subject>Pneumonia</subject><subject>Polyarthritis</subject><subject>Rheumatology</subject><subject>Rodents</subject><subject>Sepsis</subject><subject>Sepsis - drug therapy</subject><subject>Sepsis - microbiology</subject><subject>Staphylococcal infections</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcus</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Therapy</subject><subject>TNF inhibitors</subject><subject>X-Ray Microtomography</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk19v0zAUxSMEYmPwDRBEQkLw0GLHjhO_IFUTfyoVTVoHr-bGuUk9pXGwncG-Pe7aTQvaA8qDrevfOck9zk2Sl5TMKSvoh0s7uh66-WB7nBPKqOD5o-SYSpbNREbY43v7o-SZ95eE5KwU4mlylAnK8oKVx8nP5WpG03PUOATr0kUfoLW98SG9cAhhi31IF23r4AoC-nQdYNhcd1ZbraFL11FldLpwYeNMMD6Fvt4VfdyaPv1mND5PnjTQeXxxWE-S758_XZx-na3OvixPF6uZLqQIMy2buhDAK0Zkg40msuKMlIXUeZZREDnHquIFl4BZXgPFBmkDjAndAIGsYSfJ673v0FmvDuF4RYVktJQxnEgs90Rt4VINzmzBXSsLRt0UrGsVuNhOh0rIXBAUmQbd8BKhAslRUFKXNSt5nkev2d7L_8ZhrCZu7TioWGpH5VFlVPJ4DSfJx8PXjdUWax1jddBNZNOT3mxUa68U56WUJIsG7w4Gzv4a0Qe1NV5j10GPdrzpk0uRi4JE9M0_6MNpHKgWYsOmb2x8r96ZqgXPSFYWnItIzR-g4lPj1uj45zUm1ieC9xNBZAL-CS2M3qvl-vz_2bMfU_btPXaD0IWNt90YjO39FOR7UDvrvcPmLmRK1G5wbtNQu8FRh8GJslf3L-hOdDsp7C-btBPQ</recordid><startdate>20150702</startdate><enddate>20150702</enddate><creator>Ali, Abukar</creator><creator>Na, Manli</creator><creator>Svensson, Mattias N D</creator><creator>Magnusson, Malin</creator><creator>Welin, Amanda</creator><creator>Schwarze, Jan-Christoph</creator><creator>Mohammad, Majd</creator><creator>Josefsson, Elisabet</creator><creator>Pullerits, Rille</creator><creator>Jin, Tao</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope><scope>DOA</scope></search><sort><creationdate>20150702</creationdate><title>IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice</title><author>Ali, Abukar ; Na, Manli ; Svensson, Mattias N D ; Magnusson, Malin ; Welin, Amanda ; Schwarze, Jan-Christoph ; Mohammad, Majd ; Josefsson, Elisabet ; Pullerits, Rille ; Jin, Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c796t-c9fd76a4b309fefc09b430879c5221a654ebb4749ae25da1efe1fa336cfa0a2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antibiotics</topic><topic>Arthritis</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - microbiology</topic><topic>Arthritis, Infectious - drug therapy</topic><topic>Arthritis, Infectious - microbiology</topic><topic>B cells</topic><topic>Comparative analysis</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Disease</topic><topic>Disease Models, Animal</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Experiments</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Immune system</topic><topic>Immunologi inom det medicinska området</topic><topic>Immunology in the medical area</topic><topic>Infection</topic><topic>Infectious arthritis</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - metabolism</topic><topic>Injury prevention</topic><topic>Inoculation</topic><topic>Interleukin 1</topic><topic>Interleukin 1 receptor antagonist</topic><topic>Interleukin 1 Receptor Antagonist Protein - therapeutic use</topic><topic>Intravenous administration</topic><topic>Joint diseases</topic><topic>Joints - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ali, Abukar</au><au>Na, Manli</au><au>Svensson, Mattias N D</au><au>Magnusson, Malin</au><au>Welin, Amanda</au><au>Schwarze, Jan-Christoph</au><au>Mohammad, Majd</au><au>Josefsson, Elisabet</au><au>Pullerits, Rille</au><au>Jin, Tao</au><au>Gao, Hongwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-07-02</date><risdate>2015</risdate><volume>10</volume><issue>7</issue><spage>e0131645</spage><epage>e0131645</epage><pages>e0131645-e0131645</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Interleukin-1 receptor antagonist (IL-1Ra) is the primary therapy against autoinflammatory syndromes with robust efficacy in reducing systemic inflammation and associated organ injury. However, patients receiving IL-1Ra might be at increased risk of acquiring serious infections.
To study whether IL-1Ra treatment deteriorates Staphylococcus aureus (S. aureus) septic arthritis and sepsis in mice.
NMRI mice were treated with anakinra (IL-1Ra) daily for 7 days before intravenous inoculation with S. aureus strain Newman in both arthritogenic and lethal doses. The clinical course of septic arthritis, histopathological and radiological changes of the joints, as well as the mortality were compared between IL-1Ra treated and control groups.
IL-1Ra treated mice developed more frequent and severe clinical septic arthritis. Also, the frequency of polyarthritis was significantly higher in the mice receiving IL-1Ra therapy. In line with the data from clinical arthritis, both histological and radiological signs of septic arthritis were more pronounced in IL-1Ra treated group compared to controls. Importantly, the mortality of IL-1Ra treated mice was significantly higher than PBS treated controls.
IL-1Ra treatment significantly aggravated S. aureus induced septic arthritis and increased the mortality in these mice.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26135738</pmid><doi>10.1371/journal.pone.0131645</doi><oa>free_for_read</oa></addata></record> |
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recordid | cdi_plos_journals_1693189164 |
source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Animals Antibiotics Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - microbiology Arthritis, Infectious - drug therapy Arthritis, Infectious - microbiology B cells Comparative analysis Cytokines Cytokines - metabolism Disease Disease Models, Animal Drug dosages Drug therapy Experiments Female Health aspects Health risks Immune system Immunologi inom det medicinska området Immunology in the medical area Infection Infectious arthritis Inflammation Inflammation - drug therapy Inflammation - metabolism Injury prevention Inoculation Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - therapeutic use Intravenous administration Joint diseases Joints - pathology Kidney - pathology Laboratories Macrophages, Peritoneal - metabolism Medical research Medicine Mice Mortality Neutrophils Pneumonia Polyarthritis Rheumatology Rodents Sepsis Sepsis - drug therapy Sepsis - microbiology Staphylococcal infections Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus Staphylococcus aureus Staphylococcus infections Therapy TNF inhibitors X-Ray Microtomography |
title | IL-1 Receptor Antagonist Treatment Aggravates Staphylococcal Septic Arthritis and Sepsis in Mice |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T01%3A24%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IL-1%20Receptor%20Antagonist%20Treatment%20Aggravates%20Staphylococcal%20Septic%20Arthritis%20and%20Sepsis%20in%20Mice&rft.jtitle=PloS%20one&rft.au=Ali,%20Abukar&rft.date=2015-07-02&rft.volume=10&rft.issue=7&rft.spage=e0131645&rft.epage=e0131645&rft.pages=e0131645-e0131645&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0131645&rft_dat=%3Cgale_plos_%3EA420287446%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1693189164&rft_id=info:pmid/26135738&rft_galeid=A420287446&rft_doaj_id=oai_doaj_org_article_69560e62cacf48eaba94e610d8d38455&rfr_iscdi=true |