Cytotoxic Effect of a Novel Synthesized Carbazole Compound on A549 Lung Cancer Cell Line

Increased death rates due to lung cancer have necessitated the search for potential novel anticancer compounds such as carbazole derivatives. Carbazoles are aromatic heterocyclic compounds with anticancer, antibacterial and anti-inflammatory activity. The study investigated the ability of the novel...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0129874
Hauptverfasser:	Molatlhegi, Refilwe P, Phulukdaree, Alisa, Anand, Krishnan, Gengan, Robert M, Tiloke, Charlette, Chuturgoon, Anil A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative medicine Anti-inflammatory agents Antibacterial materials Anticancer properties Antioxidants Apoptosis Apoptosis - drug effects Aromatic compounds BAX protein Bcl-2 protein bcl-2-Associated X Protein - agonists bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Bioassay Bioassays Biochemistry Cancer Carbazole Carbazoles Carbazoles - chemical synthesis Carbazoles - pharmacology Caspase Caspase-3 Caspases - genetics Caspases - metabolism Cell cycle Cell death Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cytometry Cytotoxicity Cytotoxins - chemical synthesis Cytotoxins - pharmacology Damage detection Deoxyribonucleic acid Developing countries Discipline DNA DNA damage Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Equal channel angular pressing Flow cytometry Gene expression Gene Expression Regulation, Neoplastic Heat shock proteins Heterocyclic compounds Homeostasis HSP70 Heat-Shock Proteins - antagonists & inhibitors HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Humans Inflammation Laboratories LDCs Lipid Peroxidation Lung cancer Lung diseases Melting point Mortality NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects Oxygen p53 Protein Pentanones - chemical synthesis Pentanones - pharmacology Peroxidation Pharmaceutical sciences Phosphatidylserine Phosphatidylserines - metabolism Powder Proteins Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive oxygen species Reactive Oxygen Species - agonists Reactive Oxygen Species - metabolism Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Signal Transduction Superoxide Dismutase - antagonists & inhibitors Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Synthesis Toxicity Tumor proteins Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Western blotting
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