Neuroimaging Analysis of the Dopamine Basis for Apathetic Behaviors in an MPTP-Lesioned Primate Model

Apathy commonly occurs in Parkinson disease (PD) patients; however, the role of dopamine in the pathophysiology of apathy remains elusive. We previously demonstrated that dopaminergic dysfunction within the ventral tegmental area (VTA)-nucleus accumbens (NAcc) pathway contributes to the manifestatio...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132064
Hauptverfasser:	Tian, LinLin, Xia, Yuanxuan, Flores, Hubert P, Campbell, Meghan C, Moerlein, Stephen M, Perlmutter, Joel S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal behavior Animals Apathy Apathy - physiology Behavior Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Correlation analysis Cortex (insular) Diagnostic imaging Dopamine Dopamine - physiology Dopamine receptors Dopamine transporter Dopaminergic Neurons - diagnostic imaging Dopaminergic Neurons - pathology Emotional behavior Goals Image processing Infusion Macaca fascicularis Macaca nemestrina Magnetic resonance Magnetic Resonance Imaging Male Medical imaging Monkeys Motor Activity Movement disorders MPTP Neurobiology Neurodegenerative diseases Neuroimaging Neurology Neurosciences NMR Nuclear magnetic resonance Nucleus accumbens Organ Specificity Parkinson's disease Parkinsonian Disorders - metabolism Parkinsonian Disorders - pathology Parkinsonian Disorders - psychology Parkinsons disease Phenols (Class of compounds) Positron emission Positron emission tomography Prefrontal cortex Primates Radiopharmaceuticals Regression analysis Single-Blind Method Studies Substantia nigra Tomography Transport buildings, stations and terminals Transporter Tropane Tyrosine 3-Monooxygenase - analysis Ventral tegmentum
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