Simultaneous Determination of Underivatized Vitamin B1 and B6 in Whole Blood by Reversed Phase Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry

Vitamin B1 (thiamine-diphosphate) and B6 (pyridoxal-5'phosphate) are micronutrients. Analysis of these micronutrients is important to diagnose potential deficiency which often occurs in elderly people due to malnutrition, in severe alcoholism and in gastrointestinal compromise due to bypass sur...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0132018-e0132018
Hauptverfasser:	Puts, Johan, de Groot, Monique, Haex, Martin, Jakobs, Bernadette
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism Amino acids Analysis Blood Blood Specimen Collection Calibration Chemistry Chromatography Chromatography, High Pressure Liquid - methods Coronary artery bypass Deuterium Drug abuse Elderly Elderly people Geriatrics Hematology High performance liquid chromatography Humans Laboratories Linearity Liquid chromatography Malnutrition Mass spectrometry Mass spectroscopy Metabolism Methods Micronutrients Older people Patients Perchloric acid Phosphate Phosphates Reagents Reference Standards Regression analysis Sample preparation Scientific imaging Sensitivity and Specificity Slopes Spectroscopy Surgery Tandem Mass Spectrometry - methods Thiamine Thiamine - blood Time Factors Vitamin B Vitamin B 6 - blood Vitamin B1 Vitamins
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