Data Mining Approaches for Genomic Biomarker Development: Applications Using Drug Screening Data from the Cancer Genome Project and the Cancer Cell Line Encyclopedia

Developing reliable biomarkers of tumor cell drug sensitivity and resistance can guide hypothesis-driven basic science research and influence pre-therapy clinical decisions. A popular strategy for developing biomarkers uses characterizations of human tumor samples against a range of cancer drug resp...

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Veröffentlicht in:	PloS one 2015-07, Vol.10 (7), p.e0127433-e0127433
1. Verfasser:	Covell, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Autophagy Bioindicators Biological activity Biomarkers Biomarkers, Tumor - genetics Cancer Cancer genetics Cancer screening Cancer therapies Cell Line, Tumor Central nervous system Cluster Analysis Clustering Computational Biology - methods Copy number Data Mining Data processing Databases, Genetic Decisions DNA Copy Number Variations Drug Discovery Drug screening Drug Screening Assays, Antitumor Drugs Encyclopedias Endoplasmic reticulum Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Gene set enrichment analysis Genomes Genomics Genomics - methods Humans Medical screening Melanoma Mutation Neoplasms - drug therapy Neoplasms - genetics Prostate Sensitivity Statistical analysis Statistical methods Technology application Therapy Tumor cells
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