Neisseria gonorrhoeae Modulates Immunity by Polarizing Human Macrophages to a M2 Profile

Current data suggest that Neisseria gonorrhoeae is able to suppress the protective immune response at different levels, such as B and T lymphocytes and antigen-presenting cells. The present report is focused on gonococcus evasion mechanism on macrophages (MФ) and its impact in the subsequent immune...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0130713-e0130713
Hauptverfasser:	Ortiz, María Carolina, Lefimil, Claudia, Rodas, Paula I, Vernal, Rolando, Lopez, Mercedes, Acuña-Castillo, Claudio, Imarai, Mónica, Escobar, Alejandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Antigen-presenting cells Antigens Apoptosis B7-H1 Antigen - immunology Cell proliferation Cell Proliferation - physiology Cytokines Dendritic cells Genotype & phenotype Gentamicin Gonorrhea Gonorrhea - immunology Gonorrhea - microbiology Health aspects Humans Immune clearance Immune response Immune system Immunity Immunofluorescence Immunosuppression Infection Infections Life assessment Ligands Lupus Lymphocytes Lymphocytes B Lymphocytes T Macrophages Macrophages - immunology Macrophages - microbiology Markers Molecular chains Monocytes Monocytes - immunology Monocytes - microbiology Mycobacterium tuberculosis Neisseria gonorrhoeae Neisseria gonorrhoeae - immunology PD-L1 protein Phagocytes Phenotype Phenotypes Polarization Sexually transmitted diseases STD Stem cells Surface markers T cell receptors T cells T-Lymphocytes - immunology T-Lymphocytes - microbiology Tuberculosis Up-Regulation - immunology
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