Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors
Delayed graft function (DGF) is an early complication of kidney transplantation (KT) associated with increased risk of early loss of graft function. DGF increases using kidneys from extended criteria donors (ECD). NGAL is a 25KDa protein proposed as biomarker of acute kidney injury. The aim of this...
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| Veröffentlicht in: | PloS one 2015-06, Vol.10 (6), p.e0129279 |
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| creator | Cantaluppi, Vincenzo Dellepiane, Sergio Tamagnone, Michela Medica, Davide Figliolini, Federico Messina, Maria Manzione, Ana Maria Gai, Massimo Tognarelli, Giuliana Ranghino, Andrea Dolla, Caterina Ferrario, Silvia Tetta, Ciro Segoloni, Giuseppe Paolo Camussi, Giovanni Biancone, Luigi |
| description | Delayed graft function (DGF) is an early complication of kidney transplantation (KT) associated with increased risk of early loss of graft function. DGF increases using kidneys from extended criteria donors (ECD). NGAL is a 25KDa protein proposed as biomarker of acute kidney injury. The aim of this study was to investigate the role of NGAL as an early and accurate indicator of DGF and Tacrolimus (Tac) toxicity and as a mediator of tissue regeneration in KT from ECD.
We evaluated plasma levels of NGAL in 50 KT patients from ECD in the first 4 days after surgery or after Tac introduction.
Plasma levels of NGAL at day 1 were significantly higher in DGF group. In the non DGF group, NGAL discriminated between slow or immediate graft function and decreased more rapidly than serum creatinine. NGAL increased after Tac introduction, suggesting a role as marker of drug toxicity. In vitro, hypoxia and Tac induced NGAL release from tubular epithelial cells (TEC) favoring an autocrine loop that sustains proliferation and inhibits apoptosis (decrease of caspases and Bax/Bcl-2 ratio).
NGAL is an early and accurate biomarker of graft function in KT from ECD favoring TEC regeneration after ischemic and nephrotoxic injury. |
| doi_str_mv | 10.1371/journal.pone.0129279 |
| format | Article |
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We evaluated plasma levels of NGAL in 50 KT patients from ECD in the first 4 days after surgery or after Tac introduction.
Plasma levels of NGAL at day 1 were significantly higher in DGF group. In the non DGF group, NGAL discriminated between slow or immediate graft function and decreased more rapidly than serum creatinine. NGAL increased after Tac introduction, suggesting a role as marker of drug toxicity. In vitro, hypoxia and Tac induced NGAL release from tubular epithelial cells (TEC) favoring an autocrine loop that sustains proliferation and inhibits apoptosis (decrease of caspases and Bax/Bcl-2 ratio).
NGAL is an early and accurate biomarker of graft function in KT from ECD favoring TEC regeneration after ischemic and nephrotoxic injury.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0129279</identifier><identifier>PMID: 26125566</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute-Phase Proteins - genetics ; Aged ; Apoptosis ; Apoptosis - drug effects ; Autocrine signalling ; BAX protein ; Bcl-2 protein ; Binding sites ; Bioindicators ; Biomarkers ; Biomarkers - blood ; Cell Hypoxia ; Cell proliferation ; Cells, Cultured ; Cohort Studies ; Creatinine ; Delayed Graft Function - blood ; Delayed Graft Function - etiology ; Diabetes ; Donor Selection ; Donors ; Epithelial cells ; Female ; Gelatinase ; Gene Expression ; Grafting ; Hemodialysis ; Humans ; Hypoxia ; Immunology ; Immunosuppressive Agents - adverse effects ; Ischemia ; Kidney - drug effects ; Kidney - physiopathology ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Kidney transplants ; Kidney Tubules - drug effects ; Kidney Tubules - pathology ; Kidney Tubules - physiopathology ; Kidneys ; Life assessment ; Lipocalin ; Lipocalin-2 ; Lipocalins - blood ; Lipocalins - genetics ; Male ; Middle Aged ; Neutrophils ; Plasma levels ; Prospective Studies ; Proteins ; Proto-Oncogene Proteins - blood ; Proto-Oncogene Proteins - genetics ; Regeneration ; Surgery ; Tacrolimus ; Tacrolimus - adverse effects ; Tissue Donors ; Tissue engineering ; Toxicity ; Transplantation ; Transplants & implants</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0129279</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Cantaluppi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Cantaluppi et al 2015 Cantaluppi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-305a80f44aa85acd959f6b5edee87bb9d9b204978bed1ebfd4e0e4f0549b52fd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488380/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488380/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26125566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cantaluppi, Vincenzo</creatorcontrib><creatorcontrib>Dellepiane, Sergio</creatorcontrib><creatorcontrib>Tamagnone, Michela</creatorcontrib><creatorcontrib>Medica, Davide</creatorcontrib><creatorcontrib>Figliolini, Federico</creatorcontrib><creatorcontrib>Messina, Maria</creatorcontrib><creatorcontrib>Manzione, Ana Maria</creatorcontrib><creatorcontrib>Gai, Massimo</creatorcontrib><creatorcontrib>Tognarelli, Giuliana</creatorcontrib><creatorcontrib>Ranghino, Andrea</creatorcontrib><creatorcontrib>Dolla, Caterina</creatorcontrib><creatorcontrib>Ferrario, Silvia</creatorcontrib><creatorcontrib>Tetta, Ciro</creatorcontrib><creatorcontrib>Segoloni, Giuseppe Paolo</creatorcontrib><creatorcontrib>Camussi, Giovanni</creatorcontrib><creatorcontrib>Biancone, Luigi</creatorcontrib><title>Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Delayed graft function (DGF) is an early complication of kidney transplantation (KT) associated with increased risk of early loss of graft function. DGF increases using kidneys from extended criteria donors (ECD). NGAL is a 25KDa protein proposed as biomarker of acute kidney injury. The aim of this study was to investigate the role of NGAL as an early and accurate indicator of DGF and Tacrolimus (Tac) toxicity and as a mediator of tissue regeneration in KT from ECD.
We evaluated plasma levels of NGAL in 50 KT patients from ECD in the first 4 days after surgery or after Tac introduction.
Plasma levels of NGAL at day 1 were significantly higher in DGF group. In the non DGF group, NGAL discriminated between slow or immediate graft function and decreased more rapidly than serum creatinine. NGAL increased after Tac introduction, suggesting a role as marker of drug toxicity. In vitro, hypoxia and Tac induced NGAL release from tubular epithelial cells (TEC) favoring an autocrine loop that sustains proliferation and inhibits apoptosis (decrease of caspases and Bax/Bcl-2 ratio).
NGAL is an early and accurate biomarker of graft function in KT from ECD favoring TEC regeneration after ischemic and nephrotoxic injury.</description><subject>Acute-Phase Proteins - genetics</subject><subject>Aged</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Autocrine signalling</subject><subject>BAX protein</subject><subject>Bcl-2 protein</subject><subject>Binding sites</subject><subject>Bioindicators</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cell Hypoxia</subject><subject>Cell proliferation</subject><subject>Cells, Cultured</subject><subject>Cohort Studies</subject><subject>Creatinine</subject><subject>Delayed Graft Function - blood</subject><subject>Delayed Graft Function - etiology</subject><subject>Diabetes</subject><subject>Donor Selection</subject><subject>Donors</subject><subject>Epithelial cells</subject><subject>Female</subject><subject>Gelatinase</subject><subject>Gene Expression</subject><subject>Grafting</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Immunology</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Ischemia</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiopathology</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney transplants</subject><subject>Kidney Tubules - drug effects</subject><subject>Kidney Tubules - pathology</subject><subject>Kidney Tubules - physiopathology</subject><subject>Kidneys</subject><subject>Life assessment</subject><subject>Lipocalin</subject><subject>Lipocalin-2</subject><subject>Lipocalins - blood</subject><subject>Lipocalins - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Plasma levels</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - blood</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Regeneration</subject><subject>Surgery</subject><subject>Tacrolimus</subject><subject>Tacrolimus - adverse effects</subject><subject>Tissue Donors</subject><subject>Tissue engineering</subject><subject>Toxicity</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9GKEzEUhgdR3HX1DUQDguBFa2aSmcncLNS1W4vFhbV6GzLJSZs6TWqSkd2n8hVNt92lBQXJRcLJ9_8n_ORk2cscD3NS5-9XrvdWdMONszDEedEUdfMoO80bUgyqApPHB-eT7FkIK4xLwqrqaXZSVHlRllV1mv3-An30brM0HZpAJ6KxIgAaheCkEREUmpmNk6IzFk0DEhaNhe9u00GhkZS9Twz6YNxa-B_gkdNo4oWO6LK3Mhpn78C5CaEHdA0LsJAU23ry-2yUhVs098KGTSds3N1o79ZofBPBqtT-wpsI3gj00Vnnw_PsiRZdgBf7_Sz7djmeX3wazK4m04vRbCDrksUBwaVgWFMqBCuFVE3Z6KotQQGwum0b1bQFpk3NWlA5tFpRwEA1LmnTloVW5Cx7vfPddC7wfdaB51VTFKwmdZGI6Y5QTqz4xpsUwS13wvC7gvMLLnw0sgNe06pUGhOoMKUK1ywnmEiWAyaszUuZvM733fp2DUqCjV50R6bHN9Ys-cL94pQyRhhOBm_2Bt797CHEfzx5Ty1EepWx2iUzuTZB8hEtMMaswXWihn-h0lKwNjL9Nm1S_Ujw7kiQmAg3cSH6EPj06_X_s1ffj9m3B-wSRBeXwXX99peEY5DuQOldCB70Q3I55tthuU-Db4eF74clyV4dpv4gup8O8ge-DRKi</recordid><startdate>20150630</startdate><enddate>20150630</enddate><creator>Cantaluppi, Vincenzo</creator><creator>Dellepiane, Sergio</creator><creator>Tamagnone, Michela</creator><creator>Medica, Davide</creator><creator>Figliolini, Federico</creator><creator>Messina, Maria</creator><creator>Manzione, Ana Maria</creator><creator>Gai, Massimo</creator><creator>Tognarelli, Giuliana</creator><creator>Ranghino, Andrea</creator><creator>Dolla, Caterina</creator><creator>Ferrario, Silvia</creator><creator>Tetta, Ciro</creator><creator>Segoloni, Giuseppe Paolo</creator><creator>Camussi, Giovanni</creator><creator>Biancone, Luigi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150630</creationdate><title>Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors</title><author>Cantaluppi, Vincenzo ; Dellepiane, Sergio ; Tamagnone, Michela ; Medica, Davide ; Figliolini, Federico ; Messina, Maria ; Manzione, Ana Maria ; Gai, Massimo ; Tognarelli, Giuliana ; Ranghino, Andrea ; Dolla, Caterina ; Ferrario, Silvia ; Tetta, Ciro ; Segoloni, Giuseppe Paolo ; Camussi, Giovanni ; Biancone, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-305a80f44aa85acd959f6b5edee87bb9d9b204978bed1ebfd4e0e4f0549b52fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute-Phase Proteins - genetics</topic><topic>Aged</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Autocrine signalling</topic><topic>BAX protein</topic><topic>Bcl-2 protein</topic><topic>Binding sites</topic><topic>Bioindicators</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Cell Hypoxia</topic><topic>Cell proliferation</topic><topic>Cells, Cultured</topic><topic>Cohort Studies</topic><topic>Creatinine</topic><topic>Delayed Graft Function - blood</topic><topic>Delayed Graft Function - etiology</topic><topic>Diabetes</topic><topic>Donor Selection</topic><topic>Donors</topic><topic>Epithelial cells</topic><topic>Female</topic><topic>Gelatinase</topic><topic>Gene Expression</topic><topic>Grafting</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Immunology</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Ischemia</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiopathology</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney transplants</topic><topic>Kidney Tubules - drug effects</topic><topic>Kidney Tubules - pathology</topic><topic>Kidney Tubules - physiopathology</topic><topic>Kidneys</topic><topic>Life assessment</topic><topic>Lipocalin</topic><topic>Lipocalin-2</topic><topic>Lipocalins - blood</topic><topic>Lipocalins - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutrophils</topic><topic>Plasma levels</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins - blood</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Regeneration</topic><topic>Surgery</topic><topic>Tacrolimus</topic><topic>Tacrolimus - adverse effects</topic><topic>Tissue Donors</topic><topic>Tissue engineering</topic><topic>Toxicity</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cantaluppi, Vincenzo</creatorcontrib><creatorcontrib>Dellepiane, Sergio</creatorcontrib><creatorcontrib>Tamagnone, Michela</creatorcontrib><creatorcontrib>Medica, Davide</creatorcontrib><creatorcontrib>Figliolini, Federico</creatorcontrib><creatorcontrib>Messina, Maria</creatorcontrib><creatorcontrib>Manzione, Ana Maria</creatorcontrib><creatorcontrib>Gai, Massimo</creatorcontrib><creatorcontrib>Tognarelli, Giuliana</creatorcontrib><creatorcontrib>Ranghino, Andrea</creatorcontrib><creatorcontrib>Dolla, Caterina</creatorcontrib><creatorcontrib>Ferrario, Silvia</creatorcontrib><creatorcontrib>Tetta, Ciro</creatorcontrib><creatorcontrib>Segoloni, Giuseppe Paolo</creatorcontrib><creatorcontrib>Camussi, Giovanni</creatorcontrib><creatorcontrib>Biancone, Luigi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale in Context : Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - 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DGF increases using kidneys from extended criteria donors (ECD). NGAL is a 25KDa protein proposed as biomarker of acute kidney injury. The aim of this study was to investigate the role of NGAL as an early and accurate indicator of DGF and Tacrolimus (Tac) toxicity and as a mediator of tissue regeneration in KT from ECD.
We evaluated plasma levels of NGAL in 50 KT patients from ECD in the first 4 days after surgery or after Tac introduction.
Plasma levels of NGAL at day 1 were significantly higher in DGF group. In the non DGF group, NGAL discriminated between slow or immediate graft function and decreased more rapidly than serum creatinine. NGAL increased after Tac introduction, suggesting a role as marker of drug toxicity. In vitro, hypoxia and Tac induced NGAL release from tubular epithelial cells (TEC) favoring an autocrine loop that sustains proliferation and inhibits apoptosis (decrease of caspases and Bax/Bcl-2 ratio).
NGAL is an early and accurate biomarker of graft function in KT from ECD favoring TEC regeneration after ischemic and nephrotoxic injury.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26125566</pmid><doi>10.1371/journal.pone.0129279</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-06, Vol.10 (6), p.e0129279 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1692287372 |
| source | PLoS; MEDLINE; PubMed Central; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Acute-Phase Proteins - genetics Aged Apoptosis Apoptosis - drug effects Autocrine signalling BAX protein Bcl-2 protein Binding sites Bioindicators Biomarkers Biomarkers - blood Cell Hypoxia Cell proliferation Cells, Cultured Cohort Studies Creatinine Delayed Graft Function - blood Delayed Graft Function - etiology Diabetes Donor Selection Donors Epithelial cells Female Gelatinase Gene Expression Grafting Hemodialysis Humans Hypoxia Immunology Immunosuppressive Agents - adverse effects Ischemia Kidney - drug effects Kidney - physiopathology Kidney transplantation Kidney Transplantation - adverse effects Kidney transplants Kidney Tubules - drug effects Kidney Tubules - pathology Kidney Tubules - physiopathology Kidneys Life assessment Lipocalin Lipocalin-2 Lipocalins - blood Lipocalins - genetics Male Middle Aged Neutrophils Plasma levels Prospective Studies Proteins Proto-Oncogene Proteins - blood Proto-Oncogene Proteins - genetics Regeneration Surgery Tacrolimus Tacrolimus - adverse effects Tissue Donors Tissue engineering Toxicity Transplantation Transplants & implants |
| title | Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T18%3A02%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neutrophil%20Gelatinase%20Associated%20Lipocalin%20Is%20an%20Early%20and%20Accurate%20Biomarker%20of%20Graft%20Function%20and%20Tissue%20Regeneration%20in%20Kidney%20Transplantation%20from%20Extended%20Criteria%20Donors&rft.jtitle=PloS%20one&rft.au=Cantaluppi,%20Vincenzo&rft.date=2015-06-30&rft.volume=10&rft.issue=6&rft.spage=e0129279&rft.pages=e0129279-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0129279&rft_dat=%3Cgale_plos_%3EA420008907%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1692287372&rft_id=info:pmid/26125566&rft_galeid=A420008907&rft_doaj_id=oai_doaj_org_article_7465df03e6044d0781303c81e038b15c&rfr_iscdi=true |