Expression of SGLT1 in Human Hearts and Impairment of Cardiac Glucose Uptake by Phlorizin during Ischemia-Reperfusion Injury in Mice

Sodium-glucose cotransporter 1 (SGLT1) is thought to be expressed in the heart as the dominant isoform of cardiac SGLT, although more information is required to delineate the subtypes of SGLTs in human hearts. Moreover, the functional role of SGLTs in the heart remains to be fully elucidated. We her...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0130605-e0130605
Hauptverfasser:	Kashiwagi, Yusuke, Nagoshi, Tomohisa, Yoshino, Takuya, Tanaka, Toshikazu D, Ito, Keiichi, Harada, Tohru, Takahashi, Hiroyuki, Ikegami, Masahiro, Anzawa, Ryuko, Yoshimura, Michihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals ATP Autopsies Cardiology Creatine Creatine kinase Diabetes Energy metabolism Fatty acids Fractionation Glucose Glucose - metabolism Glycolysis Heart Heart diseases Humans Immunoblotting Internal medicine Ischemia Laboratory animals Lactic acid Male Medicine Metabolism Mice, Inbred ICR Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - physiopathology Myocardium Myocardium - metabolism Myocardium - pathology Pathology Perfusion Phlorhizin - metabolism Protocol Recovery of Function Reperfusion Rodents Saccharomyces cerevisiae Sodium Sodium-glucose cotransporter Sodium-Glucose Transporter 1 - metabolism Triphenyltetrazolium chloride Ventricle
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