Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan
The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in treated periodontitis patients in Taiwan. From the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was...
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| creator | Chou, Shing-Hsien Tung, Ying-Chang Lin, Yu-Sheng Wu, Lung-Sheng Lin, Chia-Pin Liou, Eric Jein-Wein Chang, Chee-Jen Kung, Suefang Chu, Pao-Hsien |
| description | The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in treated periodontitis patients in Taiwan.
From the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was made between patients with mild form and severe form of treated periodontitis after propensity score matching. The primary end point was the incidence of MACE.
A total of 32,504 adult patients with treated periodontitis were identified between 2001 and 2010. After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis. During follow-up, 728 individuals in mild treated periodontitis group and 1,206 individuals in severe treated periodontitis group had at least 1 MACE event. After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08-1.46). No association was found among younger patients ≤ 60 years of age.
Severe form of treated periodontitis was associated with an increased risk of MACE among older Taiwanese patients, but not among younger Taiwanese patients. We should put more efforts on the improvement of periodontal health to prevent further MACE. |
| doi_str_mv | 10.1371/journal.pone.0130807 |
| format | Article |
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From the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was made between patients with mild form and severe form of treated periodontitis after propensity score matching. The primary end point was the incidence of MACE.
A total of 32,504 adult patients with treated periodontitis were identified between 2001 and 2010. After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis. During follow-up, 728 individuals in mild treated periodontitis group and 1,206 individuals in severe treated periodontitis group had at least 1 MACE event. After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08-1.46). No association was found among younger patients ≤ 60 years of age.
Severe form of treated periodontitis was associated with an increased risk of MACE among older Taiwanese patients, but not among younger Taiwanese patients. We should put more efforts on the improvement of periodontal health to prevent further MACE.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0130807</identifier><identifier>PMID: 26114433</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analysis ; Atherosclerosis ; Cardiology ; Cardiovascular disease ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Confidence intervals ; Databases, Factual ; Diabetes ; Diabetes mellitus ; Female ; Follow-Up Studies ; Gum disease ; Health insurance ; Health risk assessment ; Heart ; Hospitals ; Humans ; Hyperlipidemia ; Hypertension ; Incidence ; Inflammation ; Internal medicine ; Lipids ; Male ; Matching ; Medical diagnosis ; Medicine ; National health insurance ; Online databases ; Pathogens ; Patients ; Periodontitis ; Periodontitis - complications ; Periodontitis - epidemiology ; Periodontitis - therapy ; Population ; Population studies ; Population-based studies ; Porphyromonas gingivalis ; Statistics ; Studies ; Taiwan - epidemiology</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0130807-e0130807</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Chou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Chou et al 2015 Chou et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6dc02aa82b12b7ec80eb9b52dc2108cfa6b3409928dea6a135d2834ba08eafb23</citedby><cites>FETCH-LOGICAL-c692t-6dc02aa82b12b7ec80eb9b52dc2108cfa6b3409928dea6a135d2834ba08eafb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482590/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482590/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2930,23873,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26114433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kokubo, Yoshihiro</contributor><creatorcontrib>Chou, Shing-Hsien</creatorcontrib><creatorcontrib>Tung, Ying-Chang</creatorcontrib><creatorcontrib>Lin, Yu-Sheng</creatorcontrib><creatorcontrib>Wu, Lung-Sheng</creatorcontrib><creatorcontrib>Lin, Chia-Pin</creatorcontrib><creatorcontrib>Liou, Eric Jein-Wein</creatorcontrib><creatorcontrib>Chang, Chee-Jen</creatorcontrib><creatorcontrib>Kung, Suefang</creatorcontrib><creatorcontrib>Chu, Pao-Hsien</creatorcontrib><title>Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in treated periodontitis patients in Taiwan.
From the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was made between patients with mild form and severe form of treated periodontitis after propensity score matching. The primary end point was the incidence of MACE.
A total of 32,504 adult patients with treated periodontitis were identified between 2001 and 2010. After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis. During follow-up, 728 individuals in mild treated periodontitis group and 1,206 individuals in severe treated periodontitis group had at least 1 MACE event. After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08-1.46). No association was found among younger patients ≤ 60 years of age.
Severe form of treated periodontitis was associated with an increased risk of MACE among older Taiwanese patients, but not among younger Taiwanese patients. We should put more efforts on the improvement of periodontal health to prevent further MACE.</description><subject>Adult</subject><subject>Analysis</subject><subject>Atherosclerosis</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Confidence intervals</subject><subject>Databases, Factual</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gum disease</subject><subject>Health insurance</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Inflammation</subject><subject>Internal medicine</subject><subject>Lipids</subject><subject>Male</subject><subject>Matching</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>National health insurance</subject><subject>Online databases</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Periodontitis</subject><subject>Periodontitis - complications</subject><subject>Periodontitis - epidemiology</subject><subject>Periodontitis - therapy</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Porphyromonas gingivalis</subject><subject>Statistics</subject><subject>Studies</subject><subject>Taiwan - epidemiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01vEzEQhlcIREvhHyBYCQnBYYM_9pMDUohaiFTUiqZcrVnbmzhy1sH2pvTf4222VRb1gHywNX7mHc94JopeYzTBtMCf1qazLejJ1rRygjBFJSqeRMe4oiTJCaJPD85H0Qvn1ghltMzz59ERyTFOU0qPI_0D1sbGU7GT1sl4BlYoswPHOw02Pt3J1rtYtfHCSvBSxJfSKiNM65VX7nM8jS_NNqBemTb5Ci4QZ0Zrc5Ncb-Mr34nbuLFmEy9A3UD7MnrWgHby1bCfRNdnp4vZ9-T84tt8Nj1PeF4Rn-SCIwJQkhqTupC8RLKu6owITjAqeQN5TVNUVaQUEnLANBOkpGkNqJTQ1ISeRG_3ulttHBsK5RjOK5yisiBpIOZ7QhhYs61VG7C3zIBidwZjlwysV1xLRpuC0lxkuJB9DFkBJRnUqCkKVNQZD1pfhmhdvZGCh5JZ0CPR8U2rVmxpdixNS5JVKAh8GASs-d1J59lGOS61hlaa7u7dhFRpyDmg7_5BH89uoJYQElBtY0Jc3ouyaYqrDOW46KnJI1RYQm4UD13VqGAfOXwcOQTGyz9-CZ1zbH718__Zi19j9v0Bu5Kg_coZ3fVN5cZguge5Nc5Z2TwUGSPWD8V9NVg_FGwYiuD25vCDHpzup4D-BcaZB0o</recordid><startdate>20150626</startdate><enddate>20150626</enddate><creator>Chou, Shing-Hsien</creator><creator>Tung, Ying-Chang</creator><creator>Lin, Yu-Sheng</creator><creator>Wu, Lung-Sheng</creator><creator>Lin, Chia-Pin</creator><creator>Liou, Eric Jein-Wein</creator><creator>Chang, Chee-Jen</creator><creator>Kung, Suefang</creator><creator>Chu, Pao-Hsien</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150626</creationdate><title>Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan</title><author>Chou, Shing-Hsien ; Tung, Ying-Chang ; Lin, Yu-Sheng ; Wu, Lung-Sheng ; Lin, Chia-Pin ; Liou, Eric Jein-Wein ; Chang, Chee-Jen ; Kung, Suefang ; Chu, Pao-Hsien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6dc02aa82b12b7ec80eb9b52dc2108cfa6b3409928dea6a135d2834ba08eafb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Atherosclerosis</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chou, Shing-Hsien</au><au>Tung, Ying-Chang</au><au>Lin, Yu-Sheng</au><au>Wu, Lung-Sheng</au><au>Lin, Chia-Pin</au><au>Liou, Eric Jein-Wein</au><au>Chang, Chee-Jen</au><au>Kung, Suefang</au><au>Chu, Pao-Hsien</au><au>Kokubo, Yoshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-26</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0130807</spage><epage>e0130807</epage><pages>e0130807-e0130807</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in treated periodontitis patients in Taiwan.
From the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was made between patients with mild form and severe form of treated periodontitis after propensity score matching. The primary end point was the incidence of MACE.
A total of 32,504 adult patients with treated periodontitis were identified between 2001 and 2010. After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis. During follow-up, 728 individuals in mild treated periodontitis group and 1,206 individuals in severe treated periodontitis group had at least 1 MACE event. After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08-1.46). No association was found among younger patients ≤ 60 years of age.
Severe form of treated periodontitis was associated with an increased risk of MACE among older Taiwanese patients, but not among younger Taiwanese patients. We should put more efforts on the improvement of periodontal health to prevent further MACE.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26114433</pmid><doi>10.1371/journal.pone.0130807</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-06, Vol.10 (6), p.e0130807-e0130807 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Analysis Atherosclerosis Cardiology Cardiovascular disease Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Confidence intervals Databases, Factual Diabetes Diabetes mellitus Female Follow-Up Studies Gum disease Health insurance Health risk assessment Heart Hospitals Humans Hyperlipidemia Hypertension Incidence Inflammation Internal medicine Lipids Male Matching Medical diagnosis Medicine National health insurance Online databases Pathogens Patients Periodontitis Periodontitis - complications Periodontitis - epidemiology Periodontitis - therapy Population Population studies Population-based studies Porphyromonas gingivalis Statistics Studies Taiwan - epidemiology |
| title | Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T06%3A34%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Major%20Adverse%20Cardiovascular%20Events%20in%20Treated%20Periodontitis:%20A%20Population-Based%20Follow-Up%20Study%20from%20Taiwan&rft.jtitle=PloS%20one&rft.au=Chou,%20Shing-Hsien&rft.date=2015-06-26&rft.volume=10&rft.issue=6&rft.spage=e0130807&rft.epage=e0130807&rft.pages=e0130807-e0130807&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0130807&rft_dat=%3Cgale_plos_%3EA419506174%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1691408724&rft_id=info:pmid/26114433&rft_galeid=A419506174&rft_doaj_id=oai_doaj_org_article_3f7336d517e34bae9a325ab0f7707b5c&rfr_iscdi=true |