The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade

The cytokines interleukin (IL)-7 and thymic stromal lymphopoietin (TSLP) signal through the IL-7R subunit and play proinflammatory roles in experimental arthritis and rheumatoid arthritis (RA). We evaluated the effect of inhibition of IL-7R- and TSLPR-signalling as well as simultaneous inhibition of...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0130830-e0130830
Hauptverfasser:	Hillen, Maarten R, Hartgring, Sarita A Y, Willis, Cynthia R, Radstake, Timothy R D J, Hack, Cornelis E, Lafeber, Floris P J G, van Roon, Joel A G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antibodies, Monoclonal - pharmacology Arthritis Arthritis, Experimental - genetics Arthritis, Experimental - immunology Arthritis, Experimental - metabolism Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism CD1c antigen CD4 antigen CD40L protein Cell growth Cell proliferation Chemokines Cytokines Cytokines - genetics Cytokines - metabolism Dendritic cells Genotypes Granulocytes Helper cells Homeostasis Humans Immunology Inflammation Inflammation - genetics Inflammation - immunology Inflammation - metabolism Inhibition Interleukin Interleukin 17 Interleukin 6 Interleukin 7 Interleukin-7 - metabolism Interleukins Laboratories Lymphocytes Lymphocytes T Medical research Mice Mice, Knockout Peripheral blood Phosphates Receptors, Interleukin-7 - immunology Researchers Rheumatism Rheumatoid arthritis Rheumatoid factor Rheumatology Signal Transduction - drug effects Signaling T cell receptors T cells Thymic stromal lymphopoietin Thymus Tumor necrosis factor-TNF
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