Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics

The respiratory syncytial virus (RSV) fusion protein F is considered an attractive vaccine candidate especially in its prefusion conformation. We studied whether recombinant soluble RSV F proteins could be stabilized in a prefusion-like conformation by mutation of heptad repeat B (HRB). The results...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0130829-e0130829
Hauptverfasser:	Widjaja, Ivy, Rigter, Alan, Jacobino, Shamir, van Kuppeveld, Frank J M, Leenhouts, Kees, Palomo, Concepción, Melero, Jose A, Leusen, Jeanette H W, Haijema, Bert Jan, Rottier, Peter J M, de Haan, Cornelis A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Antibodies Antibodies, Neutralizing - pharmacology Antibodies, Viral - pharmacology Antigens Binding Sites Cell Line, Tumor Cleavage Cysteine Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - virology F protein Furin Fusion protein Gene Expression Glycoproteins HEK293 Cells Humans Immunoglobulins Immunology Infections Infectious diseases Models, Molecular Mutation Peptides Protein Binding Protein Multimerization Protein structure Protein Structure, Tertiary Proteins Reactivity Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Respiratory Mucosa - virology Respiratory syncytial virus Respiratory Syncytial Virus, Human - genetics Respiratory Syncytial Virus, Human - metabolism Vaccines Veterinary medicine Viral Fusion Proteins - antagonists & inhibitors Viral Fusion Proteins - chemistry Viral Fusion Proteins - genetics Viral Fusion Proteins - metabolism Virology Viruses
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