Integrative Transcriptome Profiling of Cognitive Aging and Its Preservation through Ser/Thr Protein Phosphatase Regulation

Environmental enrichment has been reported to delay or restore age-related cognitive deficits, however, a mechanism to account for the cause and progression of normal cognitive decline and its preservation by environmental enrichment is lacking. Using genome-wide SAGE-Seq, we provide a global assess...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0130891
Hauptverfasser:	Park, C Sehwan, Valomon, Amandine, Welzl, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - genetics Aging - metabolism Aging - psychology Animals Association Learning - physiology Behavior Bioinformatics Brain Brain research Cognition Cognition Disorders - prevention & control Cognitive ability Enrichment Environment Design Experiments Exploratory Behavior - physiology Fear - physiology Gene expression Gene Expression Profiling Gene Ontology Gene Regulatory Networks Genes Genomes Genomics Hippocampus Hippocampus - chemistry Hippocampus - enzymology Hippocampus - physiology Housing, Animal Kinases Male Maze Learning - physiology Memory Mice Mice, Inbred C57BL Molecular Sequence Data Nerve Tissue Proteins - analysis Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - physiology Phosphatase Phosphatases Phosphoprotein phosphatase Phosphoproteins - analysis Phosphorylation Play and Playthings Preservation Protein phosphatase Protein Phosphatase 1 - antagonists & inhibitors Protein Phosphatase 1 - physiology Protein Processing, Post-Translational Proteins Proteomics Random Allocation Recognition, Psychology - physiology RNA, Messenger - biosynthesis Sequence Alignment Transcriptome
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