Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration
When skeletal muscle fibers are injured, they regenerate and grow until their sizes are adjusted to surrounding muscle fibers and other relevant organs. In this study, we examined whether Mest, one of paternally expressed imprinted genes that regulates body size during development, and miR-335 locat...
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| description | When skeletal muscle fibers are injured, they regenerate and grow until their sizes are adjusted to surrounding muscle fibers and other relevant organs. In this study, we examined whether Mest, one of paternally expressed imprinted genes that regulates body size during development, and miR-335 located in the second intron of the Mest gene play roles in muscle regeneration. We generated miR-335-deficient mice, and found that miR-335 is a paternally expressed imprinted microRNA. Although both Mest and miR-335 are highly expressed during muscle development and regeneration, only Mest+/- (maternal/paternal) mice show retardation of body growth. In addition to reduced body weight in Mest+/-; DMD-null mice, decreased muscle growth was observed in Mest+/- mice during cardiotoxin-induced regeneration, suggesting roles of Mest in muscle regeneration. Moreover, expressions of H19 and Igf2r, maternally expressed imprinted genes were affected in tibialis anterior muscle of Mest+/-; DMD-null mice compared to DMD-null mice. Thus, Mest likely mediates muscle regeneration through regulation of imprinted gene networks in skeletal muscle. |
| doi_str_mv | 10.1371/journal.pone.0130436 |
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In this study, we examined whether Mest, one of paternally expressed imprinted genes that regulates body size during development, and miR-335 located in the second intron of the Mest gene play roles in muscle regeneration. We generated miR-335-deficient mice, and found that miR-335 is a paternally expressed imprinted microRNA. Although both Mest and miR-335 are highly expressed during muscle development and regeneration, only Mest+/- (maternal/paternal) mice show retardation of body growth. In addition to reduced body weight in Mest+/-; DMD-null mice, decreased muscle growth was observed in Mest+/- mice during cardiotoxin-induced regeneration, suggesting roles of Mest in muscle regeneration. Moreover, expressions of H19 and Igf2r, maternally expressed imprinted genes were affected in tibialis anterior muscle of Mest+/-; DMD-null mice compared to DMD-null mice. Thus, Mest likely mediates muscle regeneration through regulation of imprinted gene networks in skeletal muscle.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0130436</identifier><identifier>PMID: 26098312</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Body size ; Body weight ; Breast cancer ; Cell growth ; Dystrophin - genetics ; Gene expression ; Gene Expression Regulation, Developmental ; Genes ; Genetic engineering ; Growth ; Insulin-like growth factor II receptors ; Medical research ; MEST gene ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; MicroRNA ; MicroRNAs ; MicroRNAs - biosynthesis ; MicroRNAs - genetics ; miRNA ; Muscle Development - genetics ; Muscle, Skeletal - growth & development ; Muscle, Skeletal - metabolism ; Muscles ; Muscular dystrophy ; Musculoskeletal system ; Organs ; Proteins - genetics ; Proteins - metabolism ; Receptor, IGF Type 2 - genetics ; Receptor, IGF Type 2 - metabolism ; Regeneration ; Regeneration - genetics ; Regeneration - physiology ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Rodents ; Skeletal muscle ; Stem cells ; Tibialis anterior muscle ; Weight reduction</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0130436</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Hiramuki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Hiramuki et al 2015 Hiramuki et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c802t-965e533505da3be05aae0eba5b1ec493abcf28d51162da69ebb43e7f15a76b1e3</citedby><cites>FETCH-LOGICAL-c802t-965e533505da3be05aae0eba5b1ec493abcf28d51162da69ebb43e7f15a76b1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476715/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476715/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26098312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hiramuki, Yosuke</creatorcontrib><creatorcontrib>Sato, Takahiko</creatorcontrib><creatorcontrib>Furuta, Yasuhide</creatorcontrib><creatorcontrib>Surani, M Azim</creatorcontrib><creatorcontrib>Sehara-Fujisawa, Atsuko</creatorcontrib><title>Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>When skeletal muscle fibers are injured, they regenerate and grow until their sizes are adjusted to surrounding muscle fibers and other relevant organs. In this study, we examined whether Mest, one of paternally expressed imprinted genes that regulates body size during development, and miR-335 located in the second intron of the Mest gene play roles in muscle regeneration. We generated miR-335-deficient mice, and found that miR-335 is a paternally expressed imprinted microRNA. Although both Mest and miR-335 are highly expressed during muscle development and regeneration, only Mest+/- (maternal/paternal) mice show retardation of body growth. In addition to reduced body weight in Mest+/-; DMD-null mice, decreased muscle growth was observed in Mest+/- mice during cardiotoxin-induced regeneration, suggesting roles of Mest in muscle regeneration. Moreover, expressions of H19 and Igf2r, maternally expressed imprinted genes were affected in tibialis anterior muscle of Mest+/-; DMD-null mice compared to DMD-null mice. Thus, Mest likely mediates muscle regeneration through regulation of imprinted gene networks in skeletal muscle.</description><subject>Animals</subject><subject>Body size</subject><subject>Body weight</subject><subject>Breast cancer</subject><subject>Cell growth</subject><subject>Dystrophin - genetics</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes</subject><subject>Genetic engineering</subject><subject>Growth</subject><subject>Insulin-like growth factor II receptors</subject><subject>Medical research</subject><subject>MEST gene</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - biosynthesis</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Muscle Development - genetics</subject><subject>Muscle, Skeletal - growth & development</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscles</subject><subject>Muscular dystrophy</subject><subject>Musculoskeletal system</subject><subject>Organs</subject><subject>Proteins - genetics</subject><subject>Proteins - metabolism</subject><subject>Receptor, IGF Type 2 - genetics</subject><subject>Receptor, IGF Type 2 - metabolism</subject><subject>Regeneration</subject><subject>Regeneration - genetics</subject><subject>Regeneration - physiology</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Rodents</subject><subject>Skeletal muscle</subject><subject>Stem cells</subject><subject>Tibialis anterior muscle</subject><subject>Weight reduction</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl-L1DAUxYso7rr6DUQLguBDx6T50_ZFGFZdB3ZcmFVfw2162-nYacYk3dVvb8bpLlNQsH1oSH739ORwoug5JTPKMvp2YwbbQzfbmR5nhDLCmXwQndKCpYlMCXt4tD6Jnji3IUSwXMrH0UkqSZEzmp5G75fofFwOPv5sfLxsVwljIp7XNWrv4uvv2KGHLl4OTncYX1hz69cx9FW8wgZ7tOBb0z-NHtXQOXw2fs-irx8_fDn_lFxeXSzO55eJzknqk0IKFEGeiApYiUQAIMESRElR84JBqes0rwSlMq1AFliWnGFWUwGZDAw7i14edHedcWoMwCkqC8JJeGggFgeiMrBRO9tuwf5SBlr1Z8PYRoH1bbiLQl3mUnCpUyg4zXPgpa6A53WwpGXFgta78W9DucVKY-8tdBPR6UnfrlVjbhTnmcyoCAKvRgFrfgwh539YHqkGgqu2r00Q09vWaTUPvopUsGxvZvYXKrwVblsdKlC3YX8y8GYyEBiPP30Dg3Nqcb36f_bq25R9fcSuETq_dqYb9j1wU5AfQG2Ncxbr--QoUfsG36Wh9g1WY4PD2Ivj1O-H7irLfgO39upM</recordid><startdate>20150622</startdate><enddate>20150622</enddate><creator>Hiramuki, Yosuke</creator><creator>Sato, Takahiko</creator><creator>Furuta, Yasuhide</creator><creator>Surani, M Azim</creator><creator>Sehara-Fujisawa, Atsuko</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150622</creationdate><title>Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration</title><author>Hiramuki, Yosuke ; Sato, Takahiko ; Furuta, Yasuhide ; Surani, M Azim ; Sehara-Fujisawa, Atsuko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c802t-965e533505da3be05aae0eba5b1ec493abcf28d51162da69ebb43e7f15a76b1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Body size</topic><topic>Body weight</topic><topic>Breast cancer</topic><topic>Cell growth</topic><topic>Dystrophin - genetics</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes</topic><topic>Genetic engineering</topic><topic>Growth</topic><topic>Insulin-like growth factor II receptors</topic><topic>Medical research</topic><topic>MEST gene</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - biosynthesis</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Muscle Development - genetics</topic><topic>Muscle, Skeletal - growth & development</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscles</topic><topic>Muscular dystrophy</topic><topic>Musculoskeletal system</topic><topic>Organs</topic><topic>Proteins - genetics</topic><topic>Proteins - metabolism</topic><topic>Receptor, IGF Type 2 - genetics</topic><topic>Receptor, IGF Type 2 - metabolism</topic><topic>Regeneration</topic><topic>Regeneration - genetics</topic><topic>Regeneration - 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In this study, we examined whether Mest, one of paternally expressed imprinted genes that regulates body size during development, and miR-335 located in the second intron of the Mest gene play roles in muscle regeneration. We generated miR-335-deficient mice, and found that miR-335 is a paternally expressed imprinted microRNA. Although both Mest and miR-335 are highly expressed during muscle development and regeneration, only Mest+/- (maternal/paternal) mice show retardation of body growth. In addition to reduced body weight in Mest+/-; DMD-null mice, decreased muscle growth was observed in Mest+/- mice during cardiotoxin-induced regeneration, suggesting roles of Mest in muscle regeneration. Moreover, expressions of H19 and Igf2r, maternally expressed imprinted genes were affected in tibialis anterior muscle of Mest+/-; DMD-null mice compared to DMD-null mice. Thus, Mest likely mediates muscle regeneration through regulation of imprinted gene networks in skeletal muscle.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26098312</pmid><doi>10.1371/journal.pone.0130436</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Body size Body weight Breast cancer Cell growth Dystrophin - genetics Gene expression Gene Expression Regulation, Developmental Genes Genetic engineering Growth Insulin-like growth factor II receptors Medical research MEST gene Mice Mice, Inbred C57BL Mice, Knockout MicroRNA MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Muscle Development - genetics Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Muscles Muscular dystrophy Musculoskeletal system Organs Proteins - genetics Proteins - metabolism Receptor, IGF Type 2 - genetics Receptor, IGF Type 2 - metabolism Regeneration Regeneration - genetics Regeneration - physiology Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Rodents Skeletal muscle Stem cells Tibialis anterior muscle Weight reduction |
| title | Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration |
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