Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake
The mechanisms determining long-term weight maintenance after Roux-en-Y gastric bypass (RYGB) remain unclear. Cross sectional studies have suggested that enhanced energy expenditure (EE) may play a significant role and the aim of this study was to reveal the impact of RYGB on each major component co...
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| creator | Werling, Malin Fändriks, Lars Olbers, Torsten Bueter, Marco Sjöström, Lars Lönroth, Hans Wallenius, Ville Stenlöf, Kaj le Roux, Carel W |
| description | The mechanisms determining long-term weight maintenance after Roux-en-Y gastric bypass (RYGB) remain unclear. Cross sectional studies have suggested that enhanced energy expenditure (EE) may play a significant role and the aim of this study was to reveal the impact of RYGB on each major component constituting total EE.
Six obese female subjects, without other co-morbidities, were assessed before and at 10 days, 3 and 20 months after RYGB. Indirect calorimetry in a metabolic chamber was used to assess 24 h EE at each study visit. Other measurements included body composition by DEXA, gut hormone profiles and physical activity (PA) using high sensitivity accelerometers.
Median Body Mass Index decreased from 41.1 (range 39.1-44.8) at baseline to 28 kg/m2 (range 22.3-30.3) after 20 months (p |
| doi_str_mv | 10.1371/journal.pone.0129784 |
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Six obese female subjects, without other co-morbidities, were assessed before and at 10 days, 3 and 20 months after RYGB. Indirect calorimetry in a metabolic chamber was used to assess 24 h EE at each study visit. Other measurements included body composition by DEXA, gut hormone profiles and physical activity (PA) using high sensitivity accelerometers.
Median Body Mass Index decreased from 41.1 (range 39.1-44.8) at baseline to 28 kg/m2 (range 22.3-30.3) after 20 months (p<0.05). Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05). PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased. EE after a standard meal increased after surgery when adjusted for total tissue (p<0.05). After an initial drop, RQ (respiratory quotient) had increased at 20 months, both as measured during 24 h and after food intake (p<0.05).
RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0129784</identifier><identifier>PMID: 26098889</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accelerometers ; Adipose tissue ; Anastomosis, Roux-en-Y - adverse effects ; Body Composition ; Body mass ; Body mass index ; Body size ; Calorimetry ; Diabetes ; Dual energy X-ray absorptiometry ; Eating ; Education ; Energy ; Energy expenditure ; Energy Metabolism ; Exercise ; Female ; Food ; Food intake ; Gastric bypass ; Gastroenterologi ; Gastroenterology and Hepatology ; Gastrointestinal surgery ; Heart surgery ; Humans ; Humidity ; Metabolic rate ; Metabolism ; Obesity - surgery ; Patients ; Physical activity ; Respiration ; Respiratory quotient ; Rodents ; Studies ; Surgery ; Thermogenesis</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0129784-e0129784</ispartof><rights>2015 Werling et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Werling et al 2015 Werling et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-5d1e8004683dd8678a0c1cdf00658b84d2e9ea19c3cfddc7b7aeef877b572e163</citedby><cites>FETCH-LOGICAL-c564t-5d1e8004683dd8678a0c1cdf00658b84d2e9ea19c3cfddc7b7aeef877b572e163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476618/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476618/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26098889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/219291$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Covasa, Mihai</contributor><creatorcontrib>Werling, Malin</creatorcontrib><creatorcontrib>Fändriks, Lars</creatorcontrib><creatorcontrib>Olbers, Torsten</creatorcontrib><creatorcontrib>Bueter, Marco</creatorcontrib><creatorcontrib>Sjöström, Lars</creatorcontrib><creatorcontrib>Lönroth, Hans</creatorcontrib><creatorcontrib>Wallenius, Ville</creatorcontrib><creatorcontrib>Stenlöf, Kaj</creatorcontrib><creatorcontrib>le Roux, Carel W</creatorcontrib><title>Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The mechanisms determining long-term weight maintenance after Roux-en-Y gastric bypass (RYGB) remain unclear. Cross sectional studies have suggested that enhanced energy expenditure (EE) may play a significant role and the aim of this study was to reveal the impact of RYGB on each major component constituting total EE.
Six obese female subjects, without other co-morbidities, were assessed before and at 10 days, 3 and 20 months after RYGB. Indirect calorimetry in a metabolic chamber was used to assess 24 h EE at each study visit. Other measurements included body composition by DEXA, gut hormone profiles and physical activity (PA) using high sensitivity accelerometers.
Median Body Mass Index decreased from 41.1 (range 39.1-44.8) at baseline to 28 kg/m2 (range 22.3-30.3) after 20 months (p<0.05). Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05). PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased. EE after a standard meal increased after surgery when adjusted for total tissue (p<0.05). After an initial drop, RQ (respiratory quotient) had increased at 20 months, both as measured during 24 h and after food intake (p<0.05).
RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.</description><subject>Accelerometers</subject><subject>Adipose tissue</subject><subject>Anastomosis, Roux-en-Y - adverse effects</subject><subject>Body Composition</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Calorimetry</subject><subject>Diabetes</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Eating</subject><subject>Education</subject><subject>Energy</subject><subject>Energy expenditure</subject><subject>Energy Metabolism</subject><subject>Exercise</subject><subject>Female</subject><subject>Food</subject><subject>Food intake</subject><subject>Gastric bypass</subject><subject>Gastroenterologi</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastrointestinal surgery</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Humidity</subject><subject>Metabolic rate</subject><subject>Metabolism</subject><subject>Obesity - surgery</subject><subject>Patients</subject><subject>Physical activity</subject><subject>Respiration</subject><subject>Respiratory quotient</subject><subject>Rodents</subject><subject>Studies</subject><subject>Surgery</subject><subject>Thermogenesis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNptkk9v1DAQxSMEoqXwDRBE4tJLFjt2_OeCBNW2rFQJUeDAyXLs2eAla6d2TLvfnmx3W3URvtgav_fTzOgVxWuMZphw_H4VcvS6nw3BwwzhWnJBnxTHWJK6YjUiTx-9j4oXKa0Qaohg7HlxVDMkhRDyuHBXId9W4Kuf5YVOY3Sm_LQZdErltxw7iJty4U0EnSCVV5AGF_UYpurXHEYHfiy1t-XcQ-w25fx2AG_dmCOUNkfnu_I8BDsRRv0bXhbPlrpP8Gp_nxQ_zuffzz5Xl18uFmcfLyvTMDpWjcUgEKJMEGsF40Ijg41dIsQa0Qpqa5CgsTTELK01vOUaYCk4bxteA2bkpHi74w59SGq_paQwk4jI6ZBJsdgpbNArNUS31nGjgnbqrhBip3QcnelBYYQw5dIYzjitSau1QZxSKgxrmQY8saodK93AkNsDWpcHNZW6rBKoGstabvUf9t3ldg3WTCuMuj-wHf5490t14Y-ilDOGxQQ43QNiuM6QRrV2yUDfaw8h382JEWaYN5P03T_S_2-D7lQmhpQiLB-awUhtk3bvUtukqX3SJtubx4M8mO6jRf4CH7rTmw</recordid><startdate>20150622</startdate><enddate>20150622</enddate><creator>Werling, Malin</creator><creator>Fändriks, Lars</creator><creator>Olbers, Torsten</creator><creator>Bueter, Marco</creator><creator>Sjöström, Lars</creator><creator>Lönroth, Hans</creator><creator>Wallenius, Ville</creator><creator>Stenlöf, Kaj</creator><creator>le Roux, Carel W</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>AAOVB</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>F1U</scope><scope>ZZAVC</scope><scope>DOA</scope></search><sort><creationdate>20150622</creationdate><title>Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake</title><author>Werling, Malin ; Fändriks, Lars ; Olbers, Torsten ; Bueter, Marco ; Sjöström, Lars ; Lönroth, Hans ; Wallenius, Ville ; Stenlöf, Kaj ; le Roux, Carel W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-5d1e8004683dd8678a0c1cdf00658b84d2e9ea19c3cfddc7b7aeef877b572e163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Accelerometers</topic><topic>Adipose tissue</topic><topic>Anastomosis, Roux-en-Y - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Göteborgs universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Werling, Malin</au><au>Fändriks, Lars</au><au>Olbers, Torsten</au><au>Bueter, Marco</au><au>Sjöström, Lars</au><au>Lönroth, Hans</au><au>Wallenius, Ville</au><au>Stenlöf, Kaj</au><au>le Roux, Carel W</au><au>Covasa, Mihai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-22</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0129784</spage><epage>e0129784</epage><pages>e0129784-e0129784</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The mechanisms determining long-term weight maintenance after Roux-en-Y gastric bypass (RYGB) remain unclear. Cross sectional studies have suggested that enhanced energy expenditure (EE) may play a significant role and the aim of this study was to reveal the impact of RYGB on each major component constituting total EE.
Six obese female subjects, without other co-morbidities, were assessed before and at 10 days, 3 and 20 months after RYGB. Indirect calorimetry in a metabolic chamber was used to assess 24 h EE at each study visit. Other measurements included body composition by DEXA, gut hormone profiles and physical activity (PA) using high sensitivity accelerometers.
Median Body Mass Index decreased from 41.1 (range 39.1-44.8) at baseline to 28 kg/m2 (range 22.3-30.3) after 20 months (p<0.05). Lean tissue decreased from 55.9 (range 47.5-59.3) to 49.5 (range 41.1-54.9) kg and adipose tissue from 61 (range 56-64.6) to 27 (range 12-34.3) kg (both p<0.05). PA over 24 h did not change after surgery whereas 24 h EE and basal metabolic rate (BMR) decreased. EE after a standard meal increased after surgery when adjusted for total tissue (p<0.05). After an initial drop, RQ (respiratory quotient) had increased at 20 months, both as measured during 24 h and after food intake (p<0.05).
RYGB surgery up-regulates RQ and EE after food intake resulting in an increased contribution to total EE over 24 h when corrected for total tissue.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26098889</pmid><doi>10.1371/journal.pone.0129784</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-06, Vol.10 (6), p.e0129784-e0129784 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SWEPUB Freely available online; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Accelerometers Adipose tissue Anastomosis, Roux-en-Y - adverse effects Body Composition Body mass Body mass index Body size Calorimetry Diabetes Dual energy X-ray absorptiometry Eating Education Energy Energy expenditure Energy Metabolism Exercise Female Food Food intake Gastric bypass Gastroenterologi Gastroenterology and Hepatology Gastrointestinal surgery Heart surgery Humans Humidity Metabolic rate Metabolism Obesity - surgery Patients Physical activity Respiration Respiratory quotient Rodents Studies Surgery Thermogenesis |
| title | Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T05%3A49%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Roux-en-Y%20Gastric%20Bypass%20Surgery%20Increases%20Respiratory%20Quotient%20and%20Energy%20Expenditure%20during%20Food%20Intake&rft.jtitle=PloS%20one&rft.au=Werling,%20Malin&rft.date=2015-06-22&rft.volume=10&rft.issue=6&rft.spage=e0129784&rft.epage=e0129784&rft.pages=e0129784-e0129784&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0129784&rft_dat=%3Cproquest_plos_%3E1691016175%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1690399993&rft_id=info:pmid/26098889&rft_doaj_id=oai_doaj_org_article_1001479cc767423baac074448c6b6ae1&rfr_iscdi=true |