Coadministration of Hedera helix L. Extract Enabled Mice to Overcome Insufficient Protection against Influenza A/PR/8 Virus Infection under Suboptimal Treatment with Oseltamivir

Several anti-influenza drugs that reduce disease manifestation exist, and although these drugs provide clinical benefits in infected patients, their efficacy is limited by the emergence of drug-resistant influenza viruses. In the current study, we assessed the therapeutic strategy of enhancing the a...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0131089-e0131089
Hauptverfasser:	Hong, Eun-Hye, Song, Jae-Hyoung, Shim, Aeri, Lee, Bo-Ra, Kwon, Bo-Eun, Song, Hyuk-Hwan, Kim, Yeon-Jeong, Chang, Sun-Young, Jeong, Hyeon Gun, Kim, Jong Geal, Seo, Sang-Uk, Kim, HyunPyo, Kwon, YongSoo, Ko, Hyun-Jeong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Analysis Animals Anthelmintic agents Antibacterial agents Antifungal agents Antiviral activity Antiviral agents Antiviral Agents - administration & dosage Antiviral drugs Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Carbon-carbon composites CD11b antigen Chemokines Cytokines Cytokines - metabolism Cytopathogenic Effect, Viral - drug effects Drug dosages Drug resistance Drug Synergism Drug therapy Drug Therapy, Combination Drugs Enzyme Inhibitors - administration & dosage Exo-a-sialidase Fungicides Gene expression Health aspects Hedera Hedera helix Immunology In Vitro Techniques Infections Infiltration Inflammation Inflammation - drug therapy Inflammation - immunology Inflammation - pathology Influenza Influenza A Influenza A virus - drug effects Influenza A virus - pathogenicity Laboratories Lung - drug effects Lung - immunology Lung - pathology Lungs Metastases Mice Mice, Inbred C57BL Neuraminidase - antagonists & inhibitors Neutrophils Oral administration Orthomyxoviridae Orthomyxoviridae Infections - drug therapy Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - virology Oseltamivir Oseltamivir - administration & dosage Oseltamivir phosphate Pandemics Pharmacy Phytotherapy Plant Extracts - administration & dosage R&D Research & development Saponins - administration & dosage TNF inhibitors Tumor necrosis factor-TNF Tumor necrosis factor-α Viruses
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