Alcohol-Preferring Rats Show Goal Oriented Behaviour to Food Incentives but Are Neither Sign-Trackers Nor Impulsive
Drug addiction is often associated with impulsivity and altered behavioural responses to both primary and conditioned rewards. Here we investigated whether selectively bred alcohol-preferring (P) and alcohol-nonpreferring (NP) rats show differential levels of impulsivity and conditioned behavioural...
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| description | Drug addiction is often associated with impulsivity and altered behavioural responses to both primary and conditioned rewards. Here we investigated whether selectively bred alcohol-preferring (P) and alcohol-nonpreferring (NP) rats show differential levels of impulsivity and conditioned behavioural responses to food incentives. P and NP rats were assessed for impulsivity in the 5-choice serial reaction time task (5-CSRTT), a widely used translational task in humans and other animals, as well as Pavlovian conditioned approach to measure sign- and goal-tracking behaviour. Drug-naïve P and NP rats showed similar levels of impulsivity on the 5-CSRTT, assessed by the number of premature, anticipatory responses, even when the waiting interval to respond was increased. However, unlike NP rats, P rats were faster to enter the food magazine and spent more time in this area. In addition, P rats showed higher levels of goal-tracking responses than NP rats, as measured by the number of magazine nose-pokes during the presentation of a food conditioned stimulus. By contrast, NP showed higher levels of sign-tracking behaviour than P rats. Following a 4-week exposure to intermittent alcohol we confirmed that P rats had a marked preference for, and consumed more alcohol than, NP rats, but were not more impulsive when re-tested in the 5-CSRTT. These findings indicate that high alcohol preferring and drinking P rats are neither intrinsically impulsive nor do they exhibit impulsivity after exposure to alcohol. However, P rats do show increased goal-directed behaviour to food incentives and this may be associated with their strong preference for alcohol. |
| doi_str_mv | 10.1371/journal.pone.0131016 |
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Here we investigated whether selectively bred alcohol-preferring (P) and alcohol-nonpreferring (NP) rats show differential levels of impulsivity and conditioned behavioural responses to food incentives. P and NP rats were assessed for impulsivity in the 5-choice serial reaction time task (5-CSRTT), a widely used translational task in humans and other animals, as well as Pavlovian conditioned approach to measure sign- and goal-tracking behaviour. Drug-naïve P and NP rats showed similar levels of impulsivity on the 5-CSRTT, assessed by the number of premature, anticipatory responses, even when the waiting interval to respond was increased. However, unlike NP rats, P rats were faster to enter the food magazine and spent more time in this area. In addition, P rats showed higher levels of goal-tracking responses than NP rats, as measured by the number of magazine nose-pokes during the presentation of a food conditioned stimulus. By contrast, NP showed higher levels of sign-tracking behaviour than P rats. Following a 4-week exposure to intermittent alcohol we confirmed that P rats had a marked preference for, and consumed more alcohol than, NP rats, but were not more impulsive when re-tested in the 5-CSRTT. These findings indicate that high alcohol preferring and drinking P rats are neither intrinsically impulsive nor do they exhibit impulsivity after exposure to alcohol. However, P rats do show increased goal-directed behaviour to food incentives and this may be associated with their strong preference for alcohol.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0131016</identifier><identifier>PMID: 26098361</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alcohol Drinking - physiopathology ; Alcoholic beverages ; Alcoholism ; Alcoholism - physiopathology ; Animals ; Behavior ; Choice Behavior - physiology ; Cocaine ; Conditioned stimulus ; Conditioning ; Drinking (Alcoholic beverages) ; Drinking - physiology ; Drinking behavior ; Drug abuse ; Drug addiction ; Ethanol ; Ethanol - administration & dosage ; Exposure ; Food ; Food Preferences - physiology ; Goals ; Impulsive behavior ; Impulsive Behavior - physiology ; Impulsivity ; Incentives ; Male ; Motivation - physiology ; Neurosciences ; Nose ; Preferences ; Psychopharmacology ; Rats ; Reaction time ; Reaction Time - physiology ; Reaction time task ; Reward ; Rodents ; Studies ; Tracking</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0131016</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Peña-Oliver et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Peña-Oliver et al 2015 Peña-Oliver et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-213ebad65afac2f9bd1781022c6f842f31859e085ec2a6deba3715067fc939703</citedby><cites>FETCH-LOGICAL-c692t-213ebad65afac2f9bd1781022c6f842f31859e085ec2a6deba3715067fc939703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476783/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476783/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26098361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pattij, Tommy</contributor><creatorcontrib>Peña-Oliver, Yolanda</creatorcontrib><creatorcontrib>Giuliano, Chiara</creatorcontrib><creatorcontrib>Economidou, Daina</creatorcontrib><creatorcontrib>Goodlett, Charles R</creatorcontrib><creatorcontrib>Robbins, Trevor W</creatorcontrib><creatorcontrib>Dalley, Jeffrey W</creatorcontrib><creatorcontrib>Everitt, Barry J</creatorcontrib><title>Alcohol-Preferring Rats Show Goal Oriented Behaviour to Food Incentives but Are Neither Sign-Trackers Nor Impulsive</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Drug addiction is often associated with impulsivity and altered behavioural responses to both primary and conditioned rewards. Here we investigated whether selectively bred alcohol-preferring (P) and alcohol-nonpreferring (NP) rats show differential levels of impulsivity and conditioned behavioural responses to food incentives. P and NP rats were assessed for impulsivity in the 5-choice serial reaction time task (5-CSRTT), a widely used translational task in humans and other animals, as well as Pavlovian conditioned approach to measure sign- and goal-tracking behaviour. Drug-naïve P and NP rats showed similar levels of impulsivity on the 5-CSRTT, assessed by the number of premature, anticipatory responses, even when the waiting interval to respond was increased. However, unlike NP rats, P rats were faster to enter the food magazine and spent more time in this area. In addition, P rats showed higher levels of goal-tracking responses than NP rats, as measured by the number of magazine nose-pokes during the presentation of a food conditioned stimulus. 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However, P rats do show increased goal-directed behaviour to food incentives and this may be associated with their strong preference for alcohol.</description><subject>Alcohol Drinking - physiopathology</subject><subject>Alcoholic beverages</subject><subject>Alcoholism</subject><subject>Alcoholism - physiopathology</subject><subject>Animals</subject><subject>Behavior</subject><subject>Choice Behavior - physiology</subject><subject>Cocaine</subject><subject>Conditioned stimulus</subject><subject>Conditioning</subject><subject>Drinking (Alcoholic beverages)</subject><subject>Drinking - physiology</subject><subject>Drinking behavior</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Ethanol</subject><subject>Ethanol - administration & dosage</subject><subject>Exposure</subject><subject>Food</subject><subject>Food Preferences - physiology</subject><subject>Goals</subject><subject>Impulsive behavior</subject><subject>Impulsive Behavior - physiology</subject><subject>Impulsivity</subject><subject>Incentives</subject><subject>Male</subject><subject>Motivation - 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By contrast, NP showed higher levels of sign-tracking behaviour than P rats. Following a 4-week exposure to intermittent alcohol we confirmed that P rats had a marked preference for, and consumed more alcohol than, NP rats, but were not more impulsive when re-tested in the 5-CSRTT. These findings indicate that high alcohol preferring and drinking P rats are neither intrinsically impulsive nor do they exhibit impulsivity after exposure to alcohol. However, P rats do show increased goal-directed behaviour to food incentives and this may be associated with their strong preference for alcohol.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26098361</pmid><doi>10.1371/journal.pone.0131016</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol Drinking - physiopathology Alcoholic beverages Alcoholism Alcoholism - physiopathology Animals Behavior Choice Behavior - physiology Cocaine Conditioned stimulus Conditioning Drinking (Alcoholic beverages) Drinking - physiology Drinking behavior Drug abuse Drug addiction Ethanol Ethanol - administration & dosage Exposure Food Food Preferences - physiology Goals Impulsive behavior Impulsive Behavior - physiology Impulsivity Incentives Male Motivation - physiology Neurosciences Nose Preferences Psychopharmacology Rats Reaction time Reaction Time - physiology Reaction time task Reward Rodents Studies Tracking |
| title | Alcohol-Preferring Rats Show Goal Oriented Behaviour to Food Incentives but Are Neither Sign-Trackers Nor Impulsive |
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