Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport

Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia (AML), where mutant NPM seems to play an oncogenic role. AML-associated NPM mu...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0130610-e0130610
Hauptverfasser:	Arregi, Igor, Falces, Jorge, Olazabal-Herrero, Anne, Alonso-Mariño, Marián, Taneva, Stefka G, Rodríguez, José A, Urbaneja, María A, Bañuelos, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Acute myeloid leukemia Affinity Anisotropy Antifungal agents Biochemistry Biosynthesis Calorimetry Cell growth Cell Nucleolus - metabolism Circular Dichroism Cytoplasm Cytoplasm - metabolism Exportin 1 Protein Exports Fluorescence Fluorescence Polarization HEK293 Cells HeLa Cells Humans Karyopherins - chemistry Karyopherins - genetics Karyopherins - metabolism Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Molecular biology Molecular chains Mutants Mutation Myeloid leukemia Nuclear Export Signals Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear transport Nucleoli Nucleophosmin Phosphorylation Physical anthropology Physiology Protein Binding Protein Structure, Tertiary Proteins Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Recognition Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Thermodynamics Titration Titration calorimetry Traffic
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