Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin

Blood brain barrier (BBB) breakdown and increased endothelial permeability is a hallmark of neuro-vascular inflammation. Angiopoietin-1 (Ang-1), a Tie-2 receptor agonist ligand, is known to modulate barrier function of endothelial cells; however the molecular mechanisms related to Ang-1 mediated rep...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0130857-e0130857
Hauptverfasser:	Siddiqui, M Rizwan, Mayanil, Chandra S, Kim, Kwang Sik, Tomita, Tadanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin Angiopoietin-1 - metabolism Angiopoietin-1 - pharmacology Blood-brain barrier Blood-Brain Barrier - metabolism Brain Brain - metabolism Brain research Capillary Permeability - drug effects Capillary Permeability - genetics Cell Membrane - metabolism Confocal microscopy Dephosphorylation Edema Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Extracellular Signal-Regulated MAP Kinases - metabolism Gene Deletion Gene Expression Homeostasis Hospitals Humans Inflammation Inflammatory diseases Intercellular Junctions - drug effects Intercellular Junctions - metabolism Ischemia Kinases Medicine Metabolism Microscopy Microvasculature Molecular chains Molecular modelling Neurosurgery Occludin - metabolism Pediatrics Permeability Phenols (Class of compounds) Phosphatase Phosphorylation Protein Transport Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism Protein-tyrosine-phosphatase Proteins Receptor, TIE-2 - metabolism siRNA Thrombin Thrombin - pharmacology Tight Junction Proteins - genetics Tight Junction Proteins - metabolism Tight junctions Tyrosine Vascular endothelial growth factor Zonula occludens-1 protein Zonula Occludens-1 Protein - metabolism
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