Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells

The direct effect of immunosuppressive drugs calcineurin inhibitor (Tacrolimus, TAC) and mTOR inhibitor (Sirolimus, SRL) on B cell activation, differentiation and proliferation is not well documented. Purified human B cells from healthy volunteers were stimulated through the B Cell Receptor with Ant...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0129658-e0129658
Hauptverfasser:	Traitanon, Opas, Mathew, James M, La Monica, Giovanna, Xu, Luting, Mas, Valeria, Gallon, Lorenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD19 - analysis Antigens, CD19 - immunology Autophagy B cells B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - immunology Calcineurin Calcineurin inhibitors CD19 antigen CD25 antigen CD27 antigen CD4 antigen CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD40 antigen CD69 antigen Cell activation Cell differentiation Cell Differentiation - drug effects Cell growth Cell proliferation Cell Proliferation - drug effects Cells, Cultured Comparative analysis Cytokines Cytokines - analysis Cytokines - immunology Differentiation (biology) Flow cytometry Histocompatibility antigen HLA Humans Immunoglobulin M Immunoglobulins Immunological memory Immunology Immunosuppressive agents Immunosuppressive Agents - pharmacology Inhibitors Interleukin 21 Lymphocyte Activation - drug effects Lymphocyte receptors Lymphocytes Lymphocytes B Lymphocytes T Medicine Memory cells Nephrology Phenotypes Plasma Plasma cells Rapamycin Sirolimus - pharmacology T cells Tacrolimus Tacrolimus - pharmacology TOR protein Transplants Transplants & implants Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology
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