Cladribine Exposure Results in a Sustained Modulation of the Cytokine Response in Human Peripheral Blood Mononuclear Cells

Cladribine is a cytotoxic drug which ameliorates the clinical course of relapsing-remitting multiple sclerosis. In addition to cytotoxicity, the mode of action may include immunomodulatory mechanisms. This in vitro study was designed to investigate cladribine's effects on cell function after th...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0129182-e0129182
Hauptverfasser:	Korsen, Melanie, Bragado Alonso, Sara, Peix, Lizzy, Bröker, Barbara M, Dressel, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bioavailability Blood Blood & organ donations Cell culture Cell proliferation Cell Proliferation - drug effects Cladribine Cladribine - pharmacology Clinical trials Cloning Cytokines Cytokines - metabolism Cytotoxicity Dendritic cells Disability Disease Experiments Exposure Female Human behavior Humans Immunomodulation Immunosuppressive Agents - pharmacology Inflammation Interferon Interleukin 10 Interleukin 23 Interleukin 4 Interleukin 5 Interleukin 6 Interleukin 8 Leukemia Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Male Medical research Medicine Mode of action Multiple sclerosis Nerve growth factor NMR Nuclear magnetic resonance Penicillin Peripheral blood mononuclear cells Toxicity Tumor necrosis factor-α
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