Rhinacanthin C Inhibits Osteoclast Differentiation and Bone Resorption: Roles of TRAF6/TAK1/MAPKs/NF-κB/NFATc1 Signaling

Rhinacanthin C is a naphthoquinone ester with anti-inflammatory activity, found in Rhinacanthus nasutus (L) Kurz (Acanthaceae). We found that rhinacanthin C inhibited osteoclast differentiation stimulated by the receptor activator of nuclear factor-κB ligand (RANKL) in mouse bone marrow macrophage c...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0130174-e0130174
Hauptverfasser:	Tomomura, Mineko, Suzuki, Ryuichiro, Shirataki, Yoshiaki, Sakagami, Hiroshi, Tamura, Nobuaki, Tomomura, Akito
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Biochemistry Biocompatibility Biomedical materials Bone growth Bone marrow Bone resorption Bone Resorption - chemically induced Bone Resorption - drug therapy Bone Resorption - pathology c-Fos protein Calvaria Cell Differentiation - drug effects Complex formation Cytokines Dentistry Differentiation Enzyme Activation - drug effects Homeostasis Immunoglobulins Inflammation Inhibition Ligands Lipopolysaccharides Lymphocytes Lysis Macrophages Macrophages - cytology Male MAP Kinase Kinase Kinases - metabolism MAP Kinase Signaling System - drug effects Medical laboratories Mice Mitogen-Activated Protein Kinases - metabolism Molecular chains Molecular modelling Naphthoquinones - pharmacology Naphthoquinones - therapeutic use NF-AT protein NF-kappa B - metabolism NF-κB protein NFATC Transcription Factors - metabolism NMR Nuclear magnetic resonance Osteoclastogenesis Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteoporosis Pharmaceutical sciences Phosphorylation RANK Ligand - pharmacology Rhincalanus nasutus Signal transduction Spectrum analysis TAK1 protein Tissue engineering TNF Receptor-Associated Factor 6 - metabolism TRAF6 protein TRANCE protein Transcription factors Tumor necrosis factor-TNF
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