Mechanisms of Cigarette Smoke Effects on Human Airway Smooth Muscle

Cigarette smoke contributes to or exacerbates airway diseases such as asthma and COPD, where airway hyperresponsiveness and airway smooth muscle (ASM) proliferation are key features. While factors such as inflammation contribute to asthma in part by enhancing agonist-induced intracellular Ca(2+) ([C...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0128778-e0128778
Hauptverfasser:	Wylam, Mark E, Sathish, Venkatachalem, VanOosten, Sarah Kay, Freeman, Michelle, Burkholder, David, Thompson, Michael A, Pabelick, Christina M, Prakash, Y S
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase 1 - genetics ADP-ribosyl Cyclase 1 - metabolism Anesthesiology Asthma Attenuation Biomarkers Biomedical engineering Bronchi - metabolism Calcium (intracellular) Calcium - metabolism Calcium channels Calcium influx Calcium ions CD38 antigen Cell growth Cell Proliferation Chronic obstructive pulmonary disease Cigarette smoke Cigarettes Cyclin E Cytokines Female Gene Expression Humans Kinases Male Medicine Molecular biology Muscle, Smooth - metabolism Muscles Myocytes, Smooth Muscle - metabolism Orai1 protein Physiology Proliferating cell nuclear antigen Protein expression Proteins Pulmonary arteries Reactive oxygen species Reactive Oxygen Species - metabolism Regulation Regulatory proteins Respiratory System - metabolism Respiratory tract diseases RNA, Small Interfering - genetics siRNA Smoke Smoking Smoking - adverse effects Smooth muscle STIM1 protein Structure-function relationships TRPC Cation Channels - genetics TRPC Cation Channels - metabolism Tumor Necrosis Factor-alpha - metabolism
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